Issues

ABOUT THE COVER
Threonine tyrosine kinase (TTK) is a key component of the spindle assembly checkpoint. In highly proliferative cancers, such as lung cancer, TTK inhibition may be particularly potent in inducing premature exit from mitosis and subsequent cell death. In this image, Zheng and colleagues demonstrate the expression of TTK (brown dots) in patients with non-small cell lung cancer. They go on to demonstrate that the selective TTK inhibitor CFI-402257 induced cell death in murine and human lung cancer and highlight its cooperation with MAPK inhibitors. The results rationalize the Phase I clinical study of CFI-402257. Read the full study on page 1775.