Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 18, Issue 1
1 January 2019
Issue Cover
All Issues
  • Cover Image

    Cover Image

    issue cover
    ABOUT THE COVER
    Toward examining impacts of the tumor microenvironment on cancer drug delivery, Lee and colleagues applied Transparent Tissue Tomography (T3) as a new tool to visualize macromolecules in situ. The cover is adapted from a detail of a T3 snapshot of immunotherapy, showing a section of tumor excised minutes after injecting anti-PD-L1. Antibody (red) flows through the microvasculature (CD31+, cyan) and extravasates to bind to its target (PD-L1, magenta) on cancer cells (Her2+, green), reactivating cytotoxic T lymphocytes (CD8+, yellow) to restore anti-tumor immune response. For details, see article on page 213.
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
Open the PDF for in another window

Small Molecule Therapeutics

Author Choice
Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Liangxian Cao; Marla Weetall; Christopher Trotta; Katherine Cintron; Jiyuan Ma; Min Jung Kim; Bansri Furia; Charles Romfo; Jason D. Graci; Wencheng Li; Joshua Du; Josephine Sheedy; Jean Hedrick; Nicole Risher; Shirley Yeh; Hongyan Qi; Tamil Arasu; Seongwoo Hwang; William Lennox; Ronald Kong; Janet Petruska; Young-Choon Moon; John Babiak; Thomas W. Davis; Allan Jacobson; Neil G. Almstead; Art Branstrom; Joseph M. Colacino; Stuart W. Peltz
View articletitled, Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Supplementary data
Open the PDF for in another window
Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer
Frank Aboubakar Nana; Marylène Lecocq; Maha Zohra Ladjemi; Bruno Detry; Sébastien Dupasquier; Olivier Feron; Pierre P. Massion; Yves Sibille; Charles Pilette; Sebahat Ocak
View articletitled, Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer
Supplementary data
Open the PDF for in another window
Author Choice
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
Tim H. Holmström; Anu-Maarit Moilanen; Tarja Ikonen; Mari L. Björkman; Tero Linnanen; Gerd Wohlfahrt; Stefan Karlsson; Riikka Oksala; Timo Korjamo; Susanta Samajdar; Srinivasan Rajagopalan; Shekar Chelur; Kishore Narayanan; Raghuveer K. Ramachandra; Jiju Mani; Rashmi Nair; Nagaraj Gowda; Thomas Anthony; Samiulla Dhodheri; Subhendu Mukherjee; Ravi K. Ujjinamatada; Nanduri Srinivas; Murali Ramachandra; Pekka J. Kallio
View articletitled, ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
Supplementary data
Open the PDF for in another window
Hsp70 Binds to the Androgen Receptor N-terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells
Jun Dong; Zeyu Wu; Dan Wang; Laura E. Pascal; Joel B. Nelson; Peter Wipf; Zhou Wang
View articletitled, Hsp70 Binds to the Androgen Receptor N-terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells
Supplementary data
Open the PDF for in another window
A Unique Nonsaccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation
Rio S. Boothello; Nirmita J. Patel; Chetna Sharon; Elsamani I. Abdelfadiel; Shravan Morla; Donald F. Brophy; H. Robert Lippman; Umesh R. Desai; Bhaumik B. Patel
View articletitled, A Unique Nonsaccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation
Supplementary data
Open the PDF for in another window
Oleanolic Acid Inhibits Epithelial–Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization
Hongzhi Wang; Weilong Zhong; Jianmin Zhao; Heng Zhang; Qiang Zhang; Yuan Liang; Shuang Chen; Huijuan Liu; Shumin Zong; Yixuan Tian; Honggang Zhou; Tao Sun; Yanrong Liu; Cheng Yang
View articletitled, Oleanolic Acid Inhibits Epithelial–Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization
Supplementary data
Open the PDF for in another window

Large Molecule Therapeutics

Immune Effector Functions of Human IgG2 Antibodies against EGFR
Thies Rösner; Steffen Kahle; Francesca Montenegro; Hanke L. Matlung; J.H. Marco Jansen; Mitchell Evers; Frank Beurskens; Jeanette H.W. Leusen; Timo K. van den Berg; Thomas Valerius
View articletitled, Immune Effector Functions of Human IgG2 Antibodies against EGFR
Supplementary data
Open the PDF for in another window
Author Choice
Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition
Haihong Zhong; Cui Chen; Ravinder Tammali; Shannon Breen; Jing Zhang; Christine Fazenbaker; Maureen Kennedy; James Conway; Brandon W. Higgs; Nicholas Holoweckyj; Rajiv Raja; Jay Harper; Andrew J. Pierce; Ronald Herbst; David A. Tice
View articletitled, Improved Therapeutic Window in <em>BRCA</em>-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition
Supplementary data
Open the PDF for in another window
Author Choice
Anti-MET VHH Pool Overcomes MET-Targeted Cancer Therapeutic Resistance
Zhipeng Su; Yunchun Han; Qichen Sun; Xiaoxiao Wang; Ting Xu; Wei Xie; Xing Huang
View articletitled, Anti-MET VHH Pool Overcomes MET-Targeted Cancer Therapeutic Resistance
Supplementary data
Open the PDF for in another window

Cancer Biology and Translational Studies

KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR
Kaori Nakatani; Toshimitsu Yamaoka; Motoi Ohba; Ken-Ichi Fujita; Satoru Arata; Sojiro Kusumoto; Iori Taki-Takemoto; Daisuke Kamei; Shinichi Iwai; Junji Tsurutani; Tohru Ohmori
View articletitled, <em>KRAS</em> and <em>EGFR</em> Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in <em>EGFR</em>
Supplementary data
Open the PDF for in another window
Enhanced Antitumor Efficacy of Oncolytic Adenovirus–loaded Menstrual Blood–derived Mesenchymal Stem Cells in Combination with Peripheral Blood Mononuclear Cells
Rafael Moreno; Carlos Alberto Fajardo; Marti Farrera-Sal; Ana Judith Perisé-Barrios; Alvaro Morales-Molina; Ahmed Abdullah Al-Zaher; Javier García-Castro; Ramon Alemany
View articletitled, Enhanced Antitumor Efficacy of Oncolytic Adenovirus–loaded Menstrual Blood–derived Mesenchymal Stem Cells in Combination with Peripheral Blood Mononuclear Cells
Supplementary data
Open the PDF for in another window
Author Choice
TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis
Sabrina Daniela da Silva; Bin Xu; Mariana Maschietto; Fabio Albuquerque Marchi; Maisa I. Alkailani; Krikor Bijian; Dingzhang Xiao; Moulay A. Alaoui-Jamali
View articletitled, TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis
Supplementary data
Open the PDF for in another window
Identification of the Novel Role of CD24 as an Oncogenesis Regulator and Therapeutic Target for Triple-Negative Breast Cancer
Shih-Hsuan Chan; Kuo-Wang Tsai; Shu-Yi Chiu; Wen-Hung Kuo; Heng-Yi Chen; Shih Sheng Jiang; King-Jen Chang; Wen-Chun Hung; Lu-Hai Wang
View articletitled, Identification of the Novel Role of CD24 as an Oncogenesis Regulator and Therapeutic Target for Triple-Negative Breast Cancer
Supplementary data
Open the PDF for in another window
PRKRA/PACT Expression Promotes Chemoresistance of Mucinous Ovarian Cancer
Takeshi Hisamatsu; Michael McGuire; Sherry Y. Wu; Rajesha Rupaimoole; Sunila Pradeep; Emine Bayraktar; Kyunghee Noh; Wei Hu; Jean M. Hansen; Yasmin Lyons; Kshipra M. Gharpure; Archana S. Nagaraja; Lingegowda S. Mangala; Takashi Mitamura; Cristian Rodriguez-Aguayo; Young Gyu Eun; Johnathon Rose; Geoffrey Bartholomeusz; Cristina Ivan; Ju-Seog Lee; Koji Matsuo; Michael Frumovitz; Kwong K. Wong; Gabriel Lopez-Berestein; Anil K. Sood
View articletitled, <em>PRKRA</em>/PACT Expression Promotes Chemoresistance of Mucinous Ovarian Cancer
Supplementary data
Open the PDF for in another window

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

The Increased Expression of Estrogen-Related Receptor α Correlates with Wnt5a and Poor Prognosis in Patients with Glioma
Liudi Zhang; Yingfeng Zhu; Haixia Cheng; Jinsen Zhang; Yuqian Zhu; Haifei Chen; Lu Chen; Huijie Qi; Guoqiang Ren; Jianmin Tang; Mingkang Zhong; Wei Hua; Xiaojin Shi; Qunyi Li
View articletitled, The Increased Expression of Estrogen-Related Receptor α Correlates with Wnt5a and Poor Prognosis in Patients with Glioma
Supplementary data
Open the PDF for in another window
Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma
Sumati Gupta; Daniel J. Albertson; Timothy J. Parnell; Andrew Butterfield; Alexis Weston; Lisa M. Pappas; Brian Dalley; John M. O’Shea; William T. Lowrance; Bradley R. Cairns; Joshua D. Schiffman; Sunil Sharma
View articletitled, Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <em>ARID1A</em>-Mutated Advanced Urothelial Carcinoma
Supplementary data
Open the PDF for in another window
Monitoring Tumor Burden in Response to FOLFIRINOX Chemotherapy Via Profiling Circulating Cell-Free DNA in Pancreatic Cancer
Tao Wei; Qi Zhang; Xiang Li; Wei Su; Guogang Li; Tao Ma; Shunliang Gao; Jianying Lou; Risheng Que; Lei Zheng; Xueli Bai; Tingbo Liang
View articletitled, Monitoring Tumor Burden in Response to FOLFIRINOX Chemotherapy Via Profiling Circulating Cell-Free DNA in Pancreatic Cancer
Supplementary data
Open the PDF for in another window
A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics
Jelmar Quist; Hasan Mirza; Maggie C.U. Cheang; Melinda L. Telli; Joyce A. O'Shaughnessy; Christopher J. Lord; Andrew N.J. Tutt; Anita Grigoriadis
View articletitled, A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics
Supplementary data
Open the PDF for in another window

Models and Technologies

Author Choice
Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment
Steve Seung-Young Lee; Vytautas P. Bindokas; Stephen J. Kron
View articletitled, Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment
Supplementary data
Open the PDF for in another window

Acknowledgment to Reviewers

Acknowledgment to Reviewers
View articletitled, Acknowledgment to Reviewers
Open the PDF for in another window

Advertisement

Breaking
Ribociclib Plus AI Greenlighted for High-Risk Breast Cancer
AACR Releases 14th Annual Cancer Progress Report
Mesothelioma Newest Approved Indication for Pembrolizumab
View more recent articles
Latest News
AMG 193 Safe, Effective in Multiple Cancer Types
STING Immune Pathway Discovery Earns Lasker Prize
Assessing New RAF-Directed Drugs in Melanoma
View more recent articles
Research Watch
The Dynamics of Ductal Tree Remodeling Shape Mammary Field Cancerization
An Age-Associated Increase in Myelopoiesis Promotes Lung Cancer Development
Post-Fast Refeeding Drives Stem Cell Regeneration via Polyamine Metabolism
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1538-8514
  • Print ISSN 1535-7163

AACR Journals

 

 

  • Copyright © 2023 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept