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1 November 2018
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Cover Image
Cover Image
ABOUT THE COVER
Delivery of therapeutics to pancreatic ductal adenocarcinomas (PDACs) is challenging due to the physical stromal barriers surrounding these tumors. Lo and colleagues applied tumor-penetrating nanocomplexes (TPNs) to breach the stroma and effectively deliver therapeutic siRNA to PDAC. As depicted on the cover, these particles are self-assembled nanostructures comprised of tandem peptides containing both a tumor-penetrating iRGD domain and a cell-penetrating domain, PEGylated derivatives of these tandem peptides, and siRNA. TPNs delivering anti-Kras siRNA exhibited tumor-penetrating ability in 3D organoids and autochthonous tumors, and slowed PDAC growth in vivo. The modular construction of the TPN platform allows for facile adaptation for future genetic targets. - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
Small Molecule Therapeutics
Loss of NF2 Induces TGFβ Receptor 1–mediated Noncanonical and Oncogenic TGFβ Signaling: Implication of the Therapeutic Effect of TGFβ Receptor 1 Inhibitor on NF2 Syndrome
Jung-Hyun Cho; Ah-Young Oh; Soyoung Park; So-mi Kang; Min-Ho Yoon; Tae-Gyun Woo; Shin-Deok Hong; Jihwan Hwang; Nam-Chul Ha; Ho-Young Lee; Bum-Joon Park
Author Choice
Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
Maria Quanz; Eckhard Bender; Charlotte Kopitz; Sylvia Grünewald; Andreas Schlicker; Wolfgang Schwede; Ashley Eheim; Luisella Toschi; Roland Neuhaus; Carmen Richter; Joern Toedling; Claudia Merz; Ralf Lesche; Atanas Kamburov; Holger Siebeneicher; Marcus Bauser; Andrea Hägebarth
MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents
Nellie K. McDaniel; Christopher T. Cummings; Mari Iida; Justus Hülse; Hannah E. Pearson; Eleana Vasileiadi; Rebecca E. Parker; Rachel A. Orbuch; Olivia J. Ondracek; Noah B. Welke; Grace H. Kang; Kurtis D. Davies; Xiaodong Wang; Stephen V. Frye; H. Shelton Earp; Paul M. Harari; Randall J. Kimple; Deborah DeRyckere; Douglas K. Graham; Deric L. Wheeler
Author Choice
Combined Inhibition of PI3Kβ and mTOR Inhibits Growth of PTEN-null Tumors
James T. Lynch; Urszula M. Polanska; Ursula Hancox; Oona Delpuech; Juliana Maynard; Catherine Trigwell; Catherine Eberlein; Carol Lenaghan; Radoslaw Polanski; Alvaro Avivar-Valderas; Marie Cumberbatch; Teresa Klinowska; Susan E. Critchlow; Francisco Cruzalegui; Simon T. Barry
Enhanced Radiosensitivity in Solid Tumors using a Tumor-selective Alkyl Phospholipid Ether Analog
Mohamed Y. Elsaid; Ankita Shahi; Albert R. Wang; Dana C. Baiu; Chunrong Li; Lauryn R. Werner; Sorabh Singhal; Lance T. Hall; Jamey P. Weichert; Eric A. Armstrong; Bryan P. Bednarz; Paul M. Harari; Gopal Iyer; Mario Otto
Large Molecule Therapeutics
iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer
Justin H. Lo; Liangliang Hao; Mandar D. Muzumdar; Srivatsan Raghavan; Ester J. Kwon; Emilia M. Pulver; Felicia Hsu; Andrew J. Aguirre; Brian M. Wolpin; Charles S. Fuchs; William C. Hahn; Tyler Jacks; Sangeeta N. Bhatia
Author Choice
Unraveling the Interaction between Carboxylesterase 1c and the Antibody–Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice
Ruud Ubink; Eef H.C. Dirksen; Myrthe Rouwette; Ebo S. Bos; Ingrid Janssen; David F. Egging; Eline M. Loosveld; Tanja A. van Achterberg; Kim Berentsen; Miranda M.C. van der Lee; Francis Bichat; Olivier Raguin; Monique A.J. van der Vleuten; Patrick G. Groothuis; Wim H.A. Dokter
Cancer Biology and Translational Studies
Mutual Influence of ROS, pH, and CLIC1 Membrane Protein in the Regulation of G1–S Phase Progression in Human Glioblastoma Stem Cells
Marta Peretti; Federica Maddalena Raciti; Valentina Carlini; Ivan Verduci; Sarah Sertic; Sara Barozzi; Massimiliano Garré; Alessandra Pattarozzi; Antonio Daga; Federica Barbieri; Alex Costa; Tullio Florio; Michele Mazzanti
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
Author Choice
Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor
Heidi M. Namløs; Kjetil Boye; Skyler J. Mishkin; Tale Barøy; Susanne Lorenz; Bodil Bjerkehagen; Eva W. Stratford; Else Munthe; Brian A. Kudlow; Ola Myklebost; Leonardo A. Meza-Zepeda
Models and Technologies
Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts
Fallon K. Noto; Valeriya Adjan-Steffey; Min Tong; Kameswaran Ravichandran; Wei Zhang; Angela Arey; Christopher B. McClain; Eric Ostertag; Sahar Mazhar; Jaya Sangodkar; Analisa DiFeo; Jack Crawford; Goutham Narla; Tseten Y. Jamling
Retractions
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