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Volume 16, Issue 4
1 April 2017
Issue Cover
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    Cover Image

    issue cover
    ABOUT THE COVER
    The cover shows a heat map illustrating the receptor tyrosine kinase (RTK) expression levels of a subset of proneural GBM samples from the TCGA database. In this subset of proneural samples IGF1R expression is associated with survival and RTK activity.
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ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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Review

Author Choice
MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale
Ravi Salgia
View articletitled, MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale
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Small Molecule Therapeutics

AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells
Ahrum Min; Seock-Ah Im; Hyemin Jang; Seongyeong Kim; Miso Lee; Debora Keunyoung Kim; Yaewon Yang; Hee-Jun Kim; Kyung-Hun Lee; Jin Won Kim; Tae-Yong Kim; Do-Youn Oh; Jeff Brown; Alan Lau; Mark J. O'Connor; Yung-Jue Bang
View articletitled, AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells
Supplementary data
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Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152
Yu Wang; Sinan Wang; Yansheng Wu; Yu Ren; Zhaoqing Li; Xiaofeng Yao; Chao Zhang; Na Ye; Chao Jing; Jiabin Dong; Kailiang Zhang; Shanshan Sun; Minghui Zhao; Wenyu Guo; Xin Qu; Yu Qiao; Haiying Chen; Lingping Kong; Rui Jin; Xudong Wang; Lun Zhang; Jia Zhou; Qiang Shen; Xuan Zhou
View articletitled, Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152
Supplementary data
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Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances In Vitro and In Vivo Cytotoxicity in Head and Neck Squamous Cell Carcinoma
Ling Zeng; Reena R. Beggs; Tiffiny S. Cooper; Alice N. Weaver; Eddy S. Yang
View articletitled, Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances <em>In Vitro</em> and <em>In Vivo</em> Cytotoxicity in Head and Neck Squamous Cell Carcinoma
Supplementary data
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15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models
Tyvette S. Hilliard; Gabriella Miklossy; Christopher Chock; Peibin Yue; Philip Williams; James Turkson
View articletitled, 15α-methoxypuupehenol Induces Antitumor Effects <em>In Vitro</em> and <em>In Vivo</em> against Human Glioblastoma and Breast Cancer Models
Supplementary data
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Author Choice
Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398
Jharna Datta; Senthilkumar Damodaran; Hannah Parks; Cristina Ocrainiciuc; Jharna Miya; Lianbo Yu; Elijah P. Gardner; Eric Samorodnitsky; Michele R. Wing; Darshna Bhatt; John Hays; Julie W. Reeser; Sameek Roychowdhury
View articletitled, Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398
Supplementary data
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A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer
Rakesh K. Pathak; Ru Wen; Nagesh Kolishetti; Shanta Dhar
View articletitled, A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer
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PI3K Inhibitors Synergize with FGFR Inhibitors to Enhance Antitumor Responses in FGFR2mutant Endometrial Cancers
Leisl M. Packer; Xinyan Geng; Vanessa F. Bonazzi; Robert J. Ju; Clare E. Mahon; Margaret C. Cummings; Sally-Anne Stephenson; Pamela M. Pollock
View articletitled, PI3K Inhibitors Synergize with FGFR Inhibitors to Enhance Antitumor Responses in FGFR2<sup>mutant</sup> Endometrial Cancers
Supplementary data
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Reactive Oxygen Species–Mediated Synergism of Fenretinide and Romidepsin in Preclinical Models of T-cell Lymphoid Malignancies
Monish R. Makena; Balakrishna Koneru; Thinh H. Nguyen; Min H. Kang; C. Patrick Reynolds
View articletitled, Reactive Oxygen Species–Mediated Synergism of Fenretinide and Romidepsin in Preclinical Models of T-cell Lymphoid Malignancies
Supplementary data
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Large Molecule Therapeutics

Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma
Bingbing Dai; David Roife; Ya'an Kang; Joy Gumin; Mayrim V. Rios Perez; Xinqun Li; Michael Pratt; Rolf A. Brekken; Juan Fueyo-Margareto; Frederick F. Lang; Jason B. Fleming
View articletitled, Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma
Supplementary data
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Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression
Andrew J. Garton; Scott Seibel; Lori Lopresti-Morrow; Linda Crew; Neal Janson; Sreekala Mandiyan; E. Sergio Trombetta; Shannon Pankratz; Theresa M. LaVallee; Richard Gedrich
View articletitled, Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression
Supplementary data
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Author Choice
Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs
Julian Andreev; Nithya Thambi; Andres E. Perez Bay; Frank Delfino; Joel Martin; Marcus P. Kelly; Jessica R. Kirshner; Ashique Rafique; Arthur Kunz; Thomas Nittoli; Douglas MacDonald; Christopher Daly; William Olson; Gavin Thurston
View articletitled, Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs
Supplementary data
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Cancer Biology and Signal Transduction

Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells
Ho-June Lee; Yi Cao; Victoria Pham; Elizabeth Blackwood; Catherine Wilson; Marie Evangelista; Christiaan Klijn; David Stokoe; Jeff Settleman
View articletitled, Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells
Supplementary data
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Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas
Damian A. Almiron Bonnin; Cong Ran; Matthew C. Havrda; Huan Liu; Yasuyuki Hitoshi; Zhonghua Zhang; Chao Cheng; Matthew Ung; Mark A. Israel
View articletitled, Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas
Supplementary data
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Nuclear Export of Ubiquitinated Proteins Determines the Sensitivity of Colorectal Cancer to Proteasome Inhibitor
Tingyu Wu; Wei Chen; Yongwang Zhong; Xiaodan Hou; Shengyun Fang; Chen-Ying Liu; Guanghui Wang; Tong Yu; Yu-Yang Huang; Xuesong Ouyang; Henry Q.X. Li; Long Cui; Yili Yang
View articletitled, Nuclear Export of Ubiquitinated Proteins Determines the Sensitivity of Colorectal Cancer to Proteasome Inhibitor
Supplementary data
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In Vitro and In Vivo Synergistic Antitumor Activity of the Combination of BKM120 and Erlotinib in Head and Neck Cancer: Mechanism of Apoptosis and Resistance
Abu Syed Md Anisuzzaman; Abedul Haque; Dongsheng Wang; Mohammad Aminur Rahman; Chao Zhang; Zhengjia Chen; Zhuo Georgia Chen; Dong M. Shin; A.R.M. Ruhul Amin
View articletitled, <em>In Vitro</em> and <em>In Vivo</em> Synergistic Antitumor Activity of the Combination of BKM120 and Erlotinib in Head and Neck Cancer: Mechanism of Apoptosis and Resistance
Supplementary data
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Companion Diagnostics and Cancer Biomarkers

MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2
Peilong Li; Xin Zhang; Haiyan Wang; Lili Wang; Tong Liu; Lutao Du; Yongmei Yang; Chuanxin Wang
View articletitled, MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2
Supplementary data
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APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Noritaka Tanaka; Tetsuo Mashima; Anna Mizutani; Ayana Sato; Aki Aoyama; Bo Gong; Haruka Yoshida; Yukiko Muramatsu; Kento Nakata; Masaaki Matsuura; Ryohei Katayama; Satoshi Nagayama; Naoya Fujita; Yoshikazu Sugimoto; Hiroyuki Seimiya
View articletitled, <em>APC</em> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary data
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Models and Technologies

Targeted Treatment of Metastatic Breast Cancer by PLK1 siRNA Delivered by an Antioxidant Nanoparticle Platform
Jingga Morry; Worapol Ngamcherdtrakul; Shenda Gu; Moataz Reda; David J. Castro; Thanapon Sangvanich; Joe W. Gray; Wassana Yantasee
View articletitled, Targeted Treatment of Metastatic Breast Cancer by PLK1 siRNA Delivered by an Antioxidant Nanoparticle Platform
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