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1 April 2017
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ABOUT THE COVER
The cover shows a heat map illustrating the receptor tyrosine kinase (RTK) expression levels of a subset of proneural GBM samples from the TCGA database. In this subset of proneural samples IGF1R expression is associated with survival and RTK activity. - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Small Molecule Therapeutics
AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells
Ahrum Min; Seock-Ah Im; Hyemin Jang; Seongyeong Kim; Miso Lee; Debora Keunyoung Kim; Yaewon Yang; Hee-Jun Kim; Kyung-Hun Lee; Jin Won Kim; Tae-Yong Kim; Do-Youn Oh; Jeff Brown; Alan Lau; Mark J. O'Connor; Yung-Jue Bang
Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152
Yu Wang; Sinan Wang; Yansheng Wu; Yu Ren; Zhaoqing Li; Xiaofeng Yao; Chao Zhang; Na Ye; Chao Jing; Jiabin Dong; Kailiang Zhang; Shanshan Sun; Minghui Zhao; Wenyu Guo; Xin Qu; Yu Qiao; Haiying Chen; Lingping Kong; Rui Jin; Xudong Wang; Lun Zhang; Jia Zhou; Qiang Shen; Xuan Zhou
Author Choice
Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398
Jharna Datta; Senthilkumar Damodaran; Hannah Parks; Cristina Ocrainiciuc; Jharna Miya; Lianbo Yu; Elijah P. Gardner; Eric Samorodnitsky; Michele R. Wing; Darshna Bhatt; John Hays; Julie W. Reeser; Sameek Roychowdhury
Large Molecule Therapeutics
Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma
Bingbing Dai; David Roife; Ya'an Kang; Joy Gumin; Mayrim V. Rios Perez; Xinqun Li; Michael Pratt; Rolf A. Brekken; Juan Fueyo-Margareto; Frederick F. Lang; Jason B. Fleming
Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression
Andrew J. Garton; Scott Seibel; Lori Lopresti-Morrow; Linda Crew; Neal Janson; Sreekala Mandiyan; E. Sergio Trombetta; Shannon Pankratz; Theresa M. LaVallee; Richard Gedrich
Author Choice
Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs
Julian Andreev; Nithya Thambi; Andres E. Perez Bay; Frank Delfino; Joel Martin; Marcus P. Kelly; Jessica R. Kirshner; Ashique Rafique; Arthur Kunz; Thomas Nittoli; Douglas MacDonald; Christopher Daly; William Olson; Gavin Thurston
Cancer Biology and Signal Transduction
In Vitro and In Vivo Synergistic Antitumor Activity of the Combination of BKM120 and Erlotinib in Head and Neck Cancer: Mechanism of Apoptosis and Resistance
Abu Syed Md Anisuzzaman; Abedul Haque; Dongsheng Wang; Mohammad Aminur Rahman; Chao Zhang; Zhengjia Chen; Zhuo Georgia Chen; Dong M. Shin; A.R.M. Ruhul Amin
Companion Diagnostics and Cancer Biomarkers
APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Noritaka Tanaka; Tetsuo Mashima; Anna Mizutani; Ayana Sato; Aki Aoyama; Bo Gong; Haruka Yoshida; Yukiko Muramatsu; Kento Nakata; Masaaki Matsuura; Ryohei Katayama; Satoshi Nagayama; Naoya Fujita; Yoshikazu Sugimoto; Hiroyuki Seimiya
Models and Technologies
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