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1 February 2017
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Cover Image
Cover Image
ABOUT THE COVER
The cover shows a crystal structure of EGFR protein with afatinib, 2nd generation EGFR-tyrosine kinase inhibitor. Amino acid residues of the novel L792F and C797S, in addition to the conventional T790M, mutations as the mechanisms of acquired resistance against afatinib are colored. For details, see the article by Kobayashi and colleagues on page 357 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1535-7163
EISSN 1538-8514
Highlights
Commentary
Review
Small Molecule Therapeutics
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells
Yoshinori Ishikawa; Kanae Gamo; Masato Yabuki; Shinji Takagi; Kosei Toyoshima; Kazuhide Nakayama; Akiko Nakayama; Megumi Morimoto; Hitoshi Miyashita; Ryo Dairiki; Yukiko Hikichi; Naoki Tomita; Daisuke Tomita; Shinichi Imamura; Misa Iwatani; Yusuke Kamada; Satoru Matsumoto; Ryujiro Hara; Toshiyuki Nomura; Ken Tsuchida; Kazuhide Nakamura
Author Choice
Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers
Kaiming Sun; Ruzanna Atoyan; Mylissa A. Borek; Steven Dellarocca; Maria Elena S. Samson; Anna W. Ma; Guang-Xin Xu; Troy Patterson; David P. Tuck; Jaye L. Viner; Ali Fattaey; Jing Wang
Niclosamide Inhibits Oxaliplatin Neurotoxicity while Improving Colorectal Cancer Therapeutic Response
Olivier Cerles; Evelyne Benoit; Christiane Chéreau; Sandrine Chouzenoux; Florence Morin; Marie-Anne Guillaumot; Romain Coriat; Niloufar Kavian; Thomas Loussier; Pietro Santulli; Louis Marcellin; Nathaniel E.B. Saidu; Bernard Weill; Frédéric Batteux; Carole Nicco
Large Molecule Therapeutics
Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model
Kun-Yu Teng; Jianfeng Han; Xiaoli Zhang; Shu-Hao Hsu; Shun He; Nissar A. Wani; Juan M. Barajas; Linda A. Snyder; Wendy L. Frankel; Michael A. Caligiuri; Samson T. Jacob; Jianhua Yu; Kalpana Ghoshal
Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells
Emiliano Cocco; Yang Deng; Erik M. Shapiro; Ileana Bortolomai; Salvatore Lopez; Ken Lin; Stefania Bellone; Jiajia Cui; Gulden Menderes; Jonathan D. Black; Carlton L. Schwab; Elena Bonazzoli; Fan Yang; Federica Predolini; Luca Zammataro; Gary Altwerger; Christopher de Haydu; Mitchell Clark; Julio Alvarenga; Elena Ratner; Masoud Azodi; Dan-Arin Silasi; Peter E. Schwartz; Babak Litkouhi; W. Mark Saltzman; Alessandro D. Santin
Cancer Biology and Signal Transduction
Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities
Erin E. Talbert; Jennifer Yang; Thomas A. Mace; Matthew R. Farren; Alton B. Farris; Gregory S. Young; Omar Elnaggar; Zheng Che; Cynthia D. Timmers; Priyani Rajasekera; Jennifer M. Maskarinec; Mark Bloomston; Tanios Bekaii-Saab; Denis C. Guttridge; Gregory B. Lesinski
Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer
Yoshihisa Kobayashi; Koichi Azuma; Hiroki Nagai; Young Hak Kim; Yosuke Togashi; Yuichi Sesumi; Masato Chiba; Masaki Shimoji; Katsuaki Sato; Kenji Tomizawa; Toshiki Takemoto; Kazuto Nishio; Tetsuya Mitsudomi
Imatinib Spares cKit-Expressing Prostate Neuroendocrine Tumors, whereas Kills Seminal Vesicle Epithelial–Stromal Tumors by Targeting PDGFR-β
Elena Jachetti; Alice Rigoni; Lucia Bongiovanni; Ivano Arioli; Laura Botti; Mariella Parenza; Valeria Cancila; Claudia Chiodoni; Fabrizio Festinese; Matteo Bellone; Regina Tardanico; Claudio Tripodo; Mario P. Colombo
Companion Diagnostics and Cancer Biomarkers
Microdose-Induced Drug–DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice
Maike Zimmermann; Si-Si Wang; Hongyong Zhang; Tzu-yin Lin; Michael Malfatti; Kurt Haack; Ted Ognibene; Hongyuan Yang; Susan Airhart; Kenneth W. Turteltaub; George D. Cimino; Clifford G. Tepper; Alexandra Drakaki; Karim Chamie; Ralph de Vere White; Chong-xian Pan; Paul T. Henderson
Models and Technologies
Near Infrared Photoimmunotherapy in a Transgenic Mouse Model of Spontaneous Epidermal Growth Factor Receptor (EGFR)-expressing Lung Cancer
Yuko Nakamura; Zoe Weaver Ohler; Deborah Householder; Tadanobu Nagaya; Kazuhide Sato; Shuhei Okuyama; Fusa Ogata; Dagane Daar; Tieu Hoa; Peter L. Choyke; Hisataka Kobayashi
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