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Volume 15, Issue 9
1 September 2016
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    ABOUT THE COVER
    Recombinant fusion proteins of monoclonal antibodies and major histocompatibility class I complexes are potential therapeutics to increase antigenicity and facilitate elimination of tumor cells by CD8 effector T cells. This work explores novel formats to optimize potency, safety, and technical properties. For details, see the article by Schmittnaegel and colleagues beginning on page 2130.
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  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Review

BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics
Ryan S. Soderquist; Alan Eastman
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Small Molecule Therapeutics

ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
Allison E. Cherry; Brian R. Haas; Alipi V. Naydenov; Susan Fung; Cong Xu; Katie Swinney; Michael Wagenbach; Jennifer Freeling; David A. Canton; Jonathan Coy; Eric A. Horne; Barry Rickman; Juan Jesus Vicente; John D. Scott; Rodney J.Y. Ho; Denny Liggitt; Linda Wordeman; Nephi Stella
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BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
Simon J. Hogg; Andrea Newbold; Stephin J. Vervoort; Leonie A. Cluse; Benjamin P. Martin; Gareth P. Gregory; Marcus Lefebure; Eva Vidacs; Richard W. Tothill; James E. Bradner; Jake Shortt; Ricky W. Johnstone
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Author Choice
CHK1 Inhibition Radiosensitizes Head and Neck Cancers to Paclitaxel-Based Chemoradiotherapy
Holly E. Barker; Radhika Patel; Martin McLaughlin; Ulrike Schick; Shane Zaidi; Christopher M. Nutting; Katie L. Newbold; Shreerang Bhide; Kevin J. Harrington
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Acridine Derivatives as Inhibitors of the IRE1α–XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma
Dadi Jiang; Arvin B. Tam; Muthuraman Alagappan; Michael P. Hay; Aparna Gupta; Margaret M. Kozak; David E. Solow-Cordero; Pek Y. Lum; Nicholas C. Denko; Amato J. Giaccia; Quynh-Thu Le; Maho Niwa; Albert C. Koong
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A Histone Deacetylase Inhibitor, OBP-801, and Celecoxib Synergistically Inhibit the Cell Growth with Apoptosis via a DR5-Dependent Pathway in Bladder Cancer Cells
Seijiro Toriyama; Mano Horinaka; Shusuke Yasuda; Tomoyuki Taniguchi; Yuichi Aono; Toshiya Takamura; Yukako Morioka; Tsuneharu Miki; Osamu Ukimura; Toshiyuki Sakai
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αVβ3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4
Zhao-Hui Jin; Takako Furukawa; Mélissa Degardin; Aya Sugyo; Atsushi B. Tsuji; Tomoteru Yamasaki; Kazunori Kawamura; Yasuhisa Fujibayashi; Ming-Rong Zhang; Didier Boturyn; Pascal Dumy; Tsuneo Saga
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Vitamin D Enhances the Efficacy of Irinotecan through miR-627–Mediated Inhibition of Intratumoral Drug Metabolism
Meiyan Sun; Qunshu Zhang; Xiaoyu Yang; Steven Y. Qian; Bin Guo
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Author Choice
Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer
Wells S. Brown; Li Tan; Andrew Smith; Nathanael S. Gray; Michael K. Wendt
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Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer
Long Chen; Jie Li; Elia Farah; Sukumar Sarkar; Nihal Ahmad; Sanjay Gupta; James Larner; Xiaoqi Liu
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Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth
Omran Abu Aboud; Ching-Hsien Chen; William Senapedis; Erkan Baloglu; Christian Argueta; Robert H. Weiss
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Large Molecule Therapeutics

Author Choice
A New Class of Bifunctional Major Histocompatibility Class I Antibody Fusion Molecules to Redirect CD8 T Cells
Martina Schmittnaegel; Eike Hoffmann; Sabine Imhof-Jung; Cornelia Fischer; Georg Drabner; Guy Georges; Christian Klein; Hendrik Knoetgen
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Author Choice
Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin
Shanthi Ganesh; Martin L. Koser; Wendy A. Cyr; Girish R. Chopda; Junyan Tao; Xue Shui; Bo Ying; Dongyu Chen; Purva Pandya; Edmond Chipumuro; Zakir Siddiquee; Kevin Craig; Chengjung Lai; Henryk Dudek; Satdarshan P. Monga; Weimin Wang; Bob D. Brown; Marc T. Abrams
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MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer
Gabriela Hernandez-Hoyos; Toddy Sewell; Robert Bader; Jeannette Bannink; Ruth A. Chenault; Mollie Daugherty; Maria Dasovich; Hang Fang; Rebecca Gottschalk; John Kumer; Robert E. Miller; Padma Ravikumar; Jennifer Wiens; Paul A. Algate; David Bienvenue; Catherine J. McMahan; Sateesh K. Natarajan; Jane A. Gross; John W. Blankenship
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Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models
Marc H.A. Jansen; Tonny Lagerweij; A. Charlotte P. Sewing; Danielle J. Vugts; Dannis G. van Vuurden; Carla F.M. Molthoff; Viola Caretti; Susanna J.E. Veringa; Naomi Petersen; Angel M. Carcaboso; David P. Noske; W. Peter Vandertop; Pieter Wesseling; Guus A.M.S. van Dongen; Gertjan J.L. Kaspers; Esther Hulleman
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Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab
Mari Iida; Harsh Bahrar; Toni M. Brand; Hannah E. Pearson; John P. Coan; Rachel A. Orbuch; Bailey G. Flanigan; Adam D. Swick; Prashanth J. Prabakaran; Johan Lantto; Ivan D. Horak; Michael Kragh; Ravi Salgia; Randy J. Kimple; Deric L. Wheeler
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Cancer Biology and Signal Transduction

Author Choice
Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models
Soon Young Park; Yuji Piao; Kang Jin Jeong; Jianwen Dong; John F. de Groot
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Bruton's Tyrosine Kinase Inhibitors Prevent Therapeutic Escape in Breast Cancer Cells
Xianhui Wang; Jason Wong; Christopher J. Sevinsky; Leila Kokabee; Faiza Khan; Yan Sun; Douglas S. Conklin
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MiR-548an, Transcriptionally Downregulated by HIF1α/HDAC1, Suppresses Tumorigenesis of Pancreatic Cancer by Targeting Vimentin Expression
Shuai Zhu; Chi He; Shijiang Deng; Xiang li; Shipeng Cui; Zhu Zeng; Mingliang Liu; Shufeng Zhao; Jingyuan Chen; Yan Jin; Hengyu Chen; Shichang Deng; Yang Liu; Chunyou Wang; Gang Zhao
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Alterative Expression and Localization of Profilin 1/VASPpS157 and Cofilin 1/VASPpS239 Regulates Metastatic Growth and Is Modified by DHA Supplementation
Mehboob Ali; Kathryn Heyob; Naduparambil K. Jacob; Lynette K. Rogers
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Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy
Le Li; Hua Chen; Yue Gao; Yong-Wei Wang; Guang-Quan Zhang; Shang-Ha Pan; Liang Ji; Rui Kong; Gang Wang; Yue-Hui Jia; Xue-Wei Bai; Bei Sun
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A Phase I Trial to Evaluate Antibody-Dependent Cellular Cytotoxicity of Cetuximab and Lenalidomide in Advanced Colorectal and Head and Neck Cancer
Erin M. Bertino; Elizabeth L. McMichael; Xiaokui Mo; Prashant Trikha; Melanie Davis; Bonnie Paul; Michael Grever; William E. Carson; Gregory A. Otterson
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Companion Diagnostics and Cancer Biomarkers

A Phase II Biomarker-Embedded Study of Lapatinib plus Capecitabine as First-line Therapy in Patients with Advanced or Metastatic Gastric Cancer
Melissa J. LaBonte; Dongyun Yang; Wu Zhang; Peter M. Wilson; Yasir M. Nagarwala; Kevin M. Koch; Colleen Briner; Tomomi Kaneko; Sun-Young Rha; Oleg Gladkov; Susan G. Urba; Dina Sakaeva; Michael J. Pishvaian; Ruey-Kuen Hsieh; Wei-Ping Lee; Heinz-Josef Lenz
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Models and Technologies

Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer
Ilkka Liikanen; Siri Tähtinen; Kilian Guse; Theresia Gutmann; Paula Savola; Minna Oksanen; Anna Kanerva; Akseli Hemminki
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