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1 September 2016
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ABOUT THE COVERClose Modal
Recombinant fusion proteins of monoclonal antibodies and major histocompatibility class I complexes are potential therapeutics to increase antigenicity and facilitate elimination of tumor cells by CD8 effector T cells. This work explores novel formats to optimize potency, safety, and technical properties. For details, see the article by Schmittnaegel and colleagues beginning on page 2130. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Small Molecule Therapeutics
ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
Allison E. Cherry; Brian R. Haas; Alipi V. Naydenov; Susan Fung; Cong Xu; Katie Swinney; Michael Wagenbach; Jennifer Freeling; David A. Canton; Jonathan Coy; Eric A. Horne; Barry Rickman; Juan Jesus Vicente; John D. Scott; Rodney J.Y. Ho; Denny Liggitt; Linda Wordeman; Nephi Stella
BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
Simon J. Hogg; Andrea Newbold; Stephin J. Vervoort; Leonie A. Cluse; Benjamin P. Martin; Gareth P. Gregory; Marcus Lefebure; Eva Vidacs; Richard W. Tothill; James E. Bradner; Jake Shortt; Ricky W. Johnstone
Acridine Derivatives as Inhibitors of the IRE1α–XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma
Dadi Jiang; Arvin B. Tam; Muthuraman Alagappan; Michael P. Hay; Aparna Gupta; Margaret M. Kozak; David E. Solow-Cordero; Pek Y. Lum; Nicholas C. Denko; Amato J. Giaccia; Quynh-Thu Le; Maho Niwa; Albert C. Koong
A Histone Deacetylase Inhibitor, OBP-801, and Celecoxib Synergistically Inhibit the Cell Growth with Apoptosis via a DR5-Dependent Pathway in Bladder Cancer Cells
Seijiro Toriyama; Mano Horinaka; Shusuke Yasuda; Tomoyuki Taniguchi; Yuichi Aono; Toshiya Takamura; Yukako Morioka; Tsuneharu Miki; Osamu Ukimura; Toshiyuki Sakai
Large Molecule Therapeutics
Author Choice
Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin
Shanthi Ganesh; Martin L. Koser; Wendy A. Cyr; Girish R. Chopda; Junyan Tao; Xue Shui; Bo Ying; Dongyu Chen; Purva Pandya; Edmond Chipumuro; Zakir Siddiquee; Kevin Craig; Chengjung Lai; Henryk Dudek; Satdarshan P. Monga; Weimin Wang; Bob D. Brown; Marc T. Abrams
MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer
Gabriela Hernandez-Hoyos; Toddy Sewell; Robert Bader; Jeannette Bannink; Ruth A. Chenault; Mollie Daugherty; Maria Dasovich; Hang Fang; Rebecca Gottschalk; John Kumer; Robert E. Miller; Padma Ravikumar; Jennifer Wiens; Paul A. Algate; David Bienvenue; Catherine J. McMahan; Sateesh K. Natarajan; Jane A. Gross; John W. Blankenship
Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models
Marc H.A. Jansen; Tonny Lagerweij; A. Charlotte P. Sewing; Danielle J. Vugts; Dannis G. van Vuurden; Carla F.M. Molthoff; Viola Caretti; Susanna J.E. Veringa; Naomi Petersen; Angel M. Carcaboso; David P. Noske; W. Peter Vandertop; Pieter Wesseling; Guus A.M.S. van Dongen; Gertjan J.L. Kaspers; Esther Hulleman
Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab
Mari Iida; Harsh Bahrar; Toni M. Brand; Hannah E. Pearson; John P. Coan; Rachel A. Orbuch; Bailey G. Flanigan; Adam D. Swick; Prashanth J. Prabakaran; Johan Lantto; Ivan D. Horak; Michael Kragh; Ravi Salgia; Randy J. Kimple; Deric L. Wheeler
Cancer Biology and Signal Transduction
MiR-548an, Transcriptionally Downregulated by HIF1α/HDAC1, Suppresses Tumorigenesis of Pancreatic Cancer by Targeting Vimentin Expression
Shuai Zhu; Chi He; Shijiang Deng; Xiang li; Shipeng Cui; Zhu Zeng; Mingliang Liu; Shufeng Zhao; Jingyuan Chen; Yan Jin; Hengyu Chen; Shichang Deng; Yang Liu; Chunyou Wang; Gang Zhao
Companion Diagnostics and Cancer Biomarkers
A Phase II Biomarker-Embedded Study of Lapatinib plus Capecitabine as First-line Therapy in Patients with Advanced or Metastatic Gastric Cancer
Melissa J. LaBonte; Dongyun Yang; Wu Zhang; Peter M. Wilson; Yasir M. Nagarwala; Kevin M. Koch; Colleen Briner; Tomomi Kaneko; Sun-Young Rha; Oleg Gladkov; Susan G. Urba; Dina Sakaeva; Michael J. Pishvaian; Ruey-Kuen Hsieh; Wei-Ping Lee; Heinz-Josef Lenz
Models and Technologies
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