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Volume 15, Issue 5

1 May 2016

Cover Image

Cover Image

The tetravalent FAP-DR5 bispecific antibody (RG7386) is rationally designed to exhibit bivalent binding to FAP and DR5. By simultaneous binding to both targets, the death receptor on tumor cells is being hyper–cross-linked, resulting in strictly target-dependent apoptosis induction of cancer cells. For details, see the article by Brünker, Wartha, and colleagues beginning on page 946.
Table of Contents

ISSN 1535-7163

EISSN 1538-8514