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1 December 2016
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Cover Image
Cover Image
ABOUT THE COVER
The cover image shows a Pearson correlation matrix of 51 anti-cancer agents analyzed in the Oncolines and NCI-60 cancer cell line panels (blue: high correlation, orange: negative correlation). The left triangle shows clusters and correlations using data from the Oncolines panel. The right triangle is identical to the left one, only based on NCI-60 data. Both data sets reveal similar clusters (some classes are indicated). Read more on the Oncolines™ cancer cell line profiling study in the article by Uitdehaag and colleagues from page 3097 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Small Molecule Therapeutics
Cabozantinib Is Active against Human Gastrointestinal Stromal Tumor Xenografts Carrying Different KIT Mutations
Yemarshet K. Gebreyohannes; Patrick Schöffski; Thomas Van Looy; Jasmien Wellens; Lise Vreys; Jasmien Cornillie; Ulla Vanleeuw; Dana T. Aftab; Maria Debiec-Rychter; Raf Sciot; Agnieszka Wozniak
Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer
Yan Huang; Lenard M. Lichtenberger; Morgan Taylor; Justin N. Bottsford-Miller; Monika Haemmerle; Michael J. Wagner; Yasmin Lyons; Sunila Pradeep; Wei Hu; Rebecca A. Previs; Jean M. Hansen; Dexing Fang; Piotr L. Dorniak; Justyna Filant; Elizabeth J. Dial; Fangrong Shen; Hiroto Hatakeyama; Anil K. Sood
CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation
Dan-Dan Wang; Ying Chen; Zi-Bo Chen; Fang-Jie Yan; Xiao-Yang Dai; Mei-Dan Ying; Ji Cao; Jian Ma; Pei-Hua Luo; Yong-Xin Han; Yong Peng; Ying-Hui Sun; Hui Zhang; Qiao-Jun He; Bo Yang; Hong Zhu
Targeting Binding Function-3 of the Androgen Receptor Blocks Its Co-Chaperone Interactions, Nuclear Translocation, and Activation
Nada Lallous; Eric Leblanc; Ravi S.N. Munuganti; Mohamed D.H. Hassona; Nader Al Nakouzi; Shannon Awrey; Helene Morin; Mani Roshan-Moniri; Kriti Singh; Sam Lawn; Takeshi Yamazaki; Hans H. Adomat; Christophe Andre; Mads Daugaard; Robert N. Young; Emma S. Tomlinson Guns; Paul S. Rennie; Artem Cherkasov
Large Molecule Therapeutics
Development of a Novel Antibody–Drug Conjugate for the Potential Treatment of Ovarian, Lung, and Renal Cell Carcinoma Expressing TIM-1
Lawrence J. Thomas; Laura Vitale; Thomas O'Neill; Ree Y. Dolnick; Paul K. Wallace; Hans Minderman; Lauren E. Gergel; Eric M. Forsberg; James M. Boyer; James R. Storey; Catherine D. Pilsmaker; Russell A. Hammond; Jenifer Widger; Karuna Sundarapandiyan; Andrea Crocker; Henry C. Marsh, Jr; Tibor Keler
Cancer Biology and Signal Transduction
Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma
Xiaoyun Dai; Kwang Seok Ahn; Ling Zhi Wang; Chulwon Kim; Amudha Deivasigamni; Frank Arfuso; Jae-Young Um; Alan Prem Kumar; Young-Chae Chang; Dhiraj Kumar; Gopal C. Kundu; Junji Magae; Boon Cher Goh; Kam Man Hui; Gautam Sethi
Author Choice
The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate–Lactate Exchange in BRAF-Mutant Human Melanoma Cells
Teresa Delgado-Goni; Maria Falck Miniotis; Slawomir Wantuch; Harold G. Parkes; Richard Marais; Paul Workman; Martin O. Leach; Mounia Beloueche-Babari
Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis
Alfeu Zanotto-Filho; V. Pragathi Masamsetti; Eva Loranc; Sonal S. Tonapi; Aparna Gorthi; Xavier Bernard; Rosângela Mayer Gonçalves; José C.F. Moreira; Yidong Chen; Alexander J.R. Bishop
Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI–Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation
Toshimitsu Yamaoka; Tohru Ohmori; Motoi Ohba; Satoru Arata; Yasunari Kishino; Yasunori Murata; Sojiro Kusumoto; Hiroo Ishida; Takao Shirai; Takashi Hirose; Tsukasa Ohnishi; Yasutsuna Sasaki
Author Choice
Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model
Gina Lee; Brenda Auffinger; Donna Guo; Tanwir Hasan; Marc Deheeger; Alex L. Tobias; Jeong Yeon Kim; Fatemeh Atashi; Lingjiao Zhang; Maciej S. Lesniak; C. David James; Atique U. Ahmed
Companion Diagnostics and Cancer Biomarkers
Models and Technologies
Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors
Joost C.M. Uitdehaag; Jeroen A.D.M. de Roos; Martine B.W. Prinsen; Nicole Willemsen-Seegers; Judith R.F. de Vetter; Jelle Dylus; Antoon M. van Doornmalen; Jeffrey Kooijman; Masaaki Sawa; Suzanne J.C. van Gerwen; Jos de Man; Rogier C. Buijsman; Guido J.R. Zaman
Correction
Acknowledgment to Reviewers
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