Skip Nav Destination
Issues
1 October 2016
-
Cover Image
Cover Image
ABOUT THE COVER
A liposomal platform encapsulating both the third generation P-gp inhibitor tariquidar and paclitaxel was developed to overcome paclitaxel resistance in ovarian cancer cells. Liposomal paclitaxel-treated cells had a diffuse pattern of β-tubulin expression (shown in green). Treatment with liposomal tariquidar/paclitaxel resulted in cell rounding and ring-like β-tubulin formations around the nucleus. The liposomal encapsulated tariquidar and paclitaxel synergistically inhibited cell viability, blocked proliferation, and caused G2–M arrest in paclitaxel-resistant ovarian cancer cell lines. For details, see the article by Zhang, Sriraman, and colleagues on page 2282. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Small Molecule Therapeutics
Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases
Maximilien Murone; Anne Vaslin Chessex; Antoine Attinger; Raghuveer Ramachandra; Shankar J. Shetty; Girish Daginakatte; Saumitra Sengupta; Sivapriya Marappan; Samiulla Dhodheri; Stefania Rigotti; Yogeshwar Bachhav; Silvano Brienza; Peter Traxler; Marc Lang; Michel Aguet; Vincent Zoete; Olivier Michielin; Courtney Nicholas; Faye M. Johnson; Murali Ramachandra; Andres McAllister
Author Choice
Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth
Michele C. Smith; Mary M. Mader; James A. Cook; Philip Iversen; Rose Ajamie; Everett Perkins; Laura Bloem; Yvonne Y. Yip; David A. Barda; Philip P. Waid; Douglas J. Zeckner; Debra A. Young; Manuel Sanchez-Felix; Gregory P. Donoho; Volker Wacheck
Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro
Mir A. Hoda; Christine Pirker; Yawen Dong; Karin Schelch; Petra Heffeter; Kushtrim Kryeziu; Sushilla van Schoonhoven; Thomas Klikovits; Viktoria Laszlo; Anita Rozsas; Judit Ozsvar; Walter Klepetko; Balazs Döme; Michael Grusch; Balazs Hegedüs; Walter Berger
Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study
Arthur Winer; Maxwell Janosky; Beth Harrison; Judy Zhong; Dariush Moussai; Pinar Siyah; Nina Schatz-Siemers; Jennifer Zeng; Sylvia Adams; Paolo Mignatti
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases
Patrizia Sini; Ulrich Gürtler; Stephan K. Zahn; Christoph Baumann; Dorothea Rudolph; Rosa Baumgartinger; Eva Strauss; Christian Haslinger; Ulrike Tontsch-Grunt; Irene C. Waizenegger; Flavio Solca; Gerd Bader; Andreas Zoephel; Matthias Treu; Ulrich Reiser; Pilar Garin-Chesa; Guido Boehmelt; Norbert Kraut; Jens Quant; Günther R. Adolf
Author Choice
Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells
Gema Santamaría Nuñez; Carlos Mario Genes Robles; Christophe Giraudon; Juan Fernando Martínez-Leal; Emmanuel Compe; Frédéric Coin; Pablo Aviles; Carlos María Galmarini; Jean-Marc Egly
Large Molecule Therapeutics
Cancer Biology and Signal Transduction
FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Kylie A. McLaughlin; Zsuzsanna Nemeth; Conor A. Bradley; Luke Humphreys; Izabela Stasik; Catherine Fenning; Joanna Majkut; Catherine Higgins; Nyree Crawford; Caitriona Holohan; Patrick G. Johnston; Timothy Harrison; Gerard G. Hanna; Karl T. Butterworth; Kevin M. Prise; Daniel B. Longley
Author Choice
The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma
P. Olof Olsson; Renata Gustafsson; René in 't Zandt; Tomas Friman; Marco Maccarana; Emil Tykesson; Åke Oldberg; Kristofer Rubin; Sebastian Kalamajski
Author Choice
TP53 Alterations Correlate with Response to VEGF/VEGFR Inhibitors: Implications for Targeted Therapeutics
Jennifer J. Wheler; Filip Janku; Aung Naing; Yali Li; Bettzy Stephen; Ralph Zinner; Vivek Subbiah; Siqing Fu; Daniel Karp; Gerald S. Falchook; Apostolia M. Tsimberidou; Sarina Piha-Paul; Roosevelt Anderson; Danxia Ke; Vincent Miller; Roman Yelensky; J. Jack Lee; David Hong; Razelle Kurzrock
Companion Diagnostics and Cancer Biomarkers
Author Choice
EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer
Tim N. Beck; Rachel Georgopoulos; Elena I. Shagisultanova; David Sarcu; Elizabeth A. Handorf; Cara Dubyk; Miriam N. Lango; John A. Ridge; Igor Astsaturov; Ilya G. Serebriiskii; Barbara A. Burtness; Ranee Mehra; Erica A. Golemis
Models and Technologies
Advertisement
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.