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Volume 14, Issue 7
1 July 2015
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    Cover Image

    issue cover
    Schematic representation of hyaluronic acid–conjugated poly(ethylene imine)-based self-assembling nanoparticles with negatively charged siRNA encapsulated in the core. The nanoparticles were also modified with hyaluronic acid conjugated poly(ethylene glycol) for stealth effect and an epidermal growth factor receptor targeting peptide was tethered on the surface for specificity to ovarian cancer cells. For details, see the article by Talekar and colleagues on page 1521.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Small Molecule Therapeutics

Cosilencing of PKM-2 and MDR-1 Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer
Meghna Talekar; Qijun Ouyang; Michael S. Goldberg; Mansoor M. Amiji
View articletitled, Cosilencing of <em>PKM-2</em> and <em>MDR-1</em> Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer
Supplementary data
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Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models
Chaoxin Hu; Tikva Dadon; Venugopal Chenna; Shinichi Yabuuchi; Rajat Bannerji; Robert Booher; Peter Strack; Nilofer Azad; Barry D. Nelkin; Anirban Maitra
View articletitled, Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models
Supplementary data
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Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma
Ira K. Gordon; Jie Lu; Christian A. Graves; Kristin Huntoon; Jason M. Frerich; Ryan H. Hanson; Xiaoping Wang; Christopher S. Hong; Winson Ho; Michael J. Feldman; Barbara Ikejiri; Kheem Bisht; Xiaoyuan S. Chen; Anita Tandle; Chunzhang Yang; W. Tristram Arscott; Donald Ye; John D. Heiss; Russell R. Lonser; Kevin Camphausen; Zhengping Zhuang
View articletitled, Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma
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Preclinical Test of Dacomitinib, an Irreversible EGFR Inhibitor, Confirms Its Effectiveness for Glioblastoma
Cristina Zahonero; Pilar Aguilera; Carmen Ramírez-Castillejo; Marta Pajares; Maria Victoria Bolós; Diana Cantero; Angel Perez-Nuñez; Aurelio Hernández-Laín; Pilar Sánchez-Gómez; Juan Manuel Sepúlveda
View articletitled, Preclinical Test of Dacomitinib, an Irreversible EGFR Inhibitor, Confirms Its Effectiveness for Glioblastoma
Supplementary data
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Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma
Alicia M. Waters; Jerry E. Stewart; Venkatram R. Atigadda; Elizabeth Mroczek-Musulman; Donald D. Muccio; Clinton J. Grubbs; Elizabeth A. Beierle
View articletitled, Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma
Supplementary data
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Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer
Sabiha Kazim; Mokenge P. Malafa; Domenico Coppola; Kazim Husain; Sherma Zibadi; Trinayan Kashyap; Marsha Crochiere; Yosef Landesman; Tami Rashal; Daniel M. Sullivan; Amit Mahipal
View articletitled, Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer
Supplementary data
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Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo
Yun Xia; Xian-Yi Cai; Ji-Quan Fan; Li-Ling Zhang; Jing-Hua Ren; Jing Chen; Zhen-Yu Li; Rui-Guang Zhang; Fang Zhu; Gang Wu
View articletitled, Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <em>In Vitro</em> and <em>In Vivo</em>
Supplementary data
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An Oral Formulation of YK-4-279: Preclinical Efficacy and Acquired Resistance Patterns in Ewing Sarcoma
Salah-Eddine Lamhamedi-Cherradi; Brian A. Menegaz; Vandhana Ramamoorthy; Ramani A. Aiyer; Rebecca L. Maywald; Adrianna S. Buford; Dannette K. Doolittle; Kirk S. Culotta; James E. O'Dorisio; Joseph A. Ludwig
View articletitled, An Oral Formulation of YK-4-279: Preclinical Efficacy and Acquired Resistance Patterns in Ewing Sarcoma
Supplementary data
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Large Molecule Therapeutics

IMGN853, a Folate Receptor-α (FRα)–Targeting Antibody–Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors
Olga Ab; Kathleen R. Whiteman; Laura M. Bartle; Xiuxia Sun; Rajeeva Singh; Daniel Tavares; Alyssa LaBelle; Gillian Payne; Robert J. Lutz; Jan Pinkas; Victor S. Goldmacher; Thomas Chittenden; John M. Lambert
View articletitled, IMGN853, a Folate Receptor-α (FRα)–Targeting Antibody–Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors
Supplementary data
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AMG 595, an Anti-EGFRvIII Antibody–Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma
Kevin J. Hamblett; Carl J. Kozlosky; Sophia Siu; Wesley S. Chang; Hua Liu; Ian N. Foltz; Esther S. Trueblood; David Meininger; Taruna Arora; Brian Twomey; Steven L. Vonderfecht; Qing Chen; John S. Hill; William C. Fanslow
View articletitled, AMG 595, an Anti-EGFRvIII Antibody–Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma
Supplementary data
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Author Choice
Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic
Jeffrey D. Kearns; Raghida Bukhalid; Mark Sevecka; Gege Tan; Nastaran Gerami-Moayed; Shannon L. Werner; Neeraj Kohli; Olga Burenkova; Callum M. Sloss; Anne M. King; Jonathan B. Fitzgerald; Ulrik B. Nielsen; Beni B. Wolf
View articletitled, Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic
Supplementary data
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Author Choice
A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non–EGFR-Mediated Pathways
Jonathan Rios-Doria; Darrin Sabol; Jon Chesebrough; Dave Stewart; Linda Xu; Ravinder Tammali; Li Cheng; Qun Du; Kevin Schifferli; Ray Rothstein; Ching Ching Leow; Jenny Heidbrink-Thompson; Xiaofang Jin; Changshou Gao; Jay Friedman; Brandy Wilkinson; Melissa Damschroder; Andrew J. Pierce; Robert E. Hollingsworth; David A. Tice; Emil F. Michelotti
View articletitled, A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non–EGFR-Mediated Pathways
Supplementary data
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AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody–Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML
Daniel S. Pereira; Claudia I. Guevara; Liqing Jin; Nathan Mbong; Alla Verlinsky; Ssucheng J. Hsu; Hector Aviña; Sher Karki; Joseph D. Abad; Peng Yang; Sung-Ju Moon; Faisal Malik; Michael Y. Choi; Zili An; Kendall Morrison; Pia M. Challita-Eid; Fernando Doñate; Ingrid B.J. Joseph; Thomas J. Kipps; John E. Dick; David R. Stover
View articletitled, AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody–Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML
Supplementary data
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Author Choice
Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting
Rosamund C. Smith; Martin S. Cramer; Pamela J. Mitchell; Andrew Capen; Lysiane Huber; Rong Wang; Laura Myers; Bryan E. Jones; Brian J. Eastwood; Darryl Ballard; Jeff Hanson; Kelly M. Credille; Victor J. Wroblewski; Boris K. Lin; Josef G. Heuer
View articletitled, Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting
Supplementary data
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Cancer Biology and Signal Transduction

Rho Guanine Nucleotide Exchange Factor 5 Increases Lung Cancer Cell Tumorigenesis via MMP-2 and Cyclin D1 Upregulation
Ping He; Wei Wu; Kang Yang; Deli Tan; Meng Tang; Hongxiang Liu; Tao Wu; Shixin Zhang; Haidong Wang
View articletitled, Rho Guanine Nucleotide Exchange Factor 5 Increases Lung Cancer Cell Tumorigenesis via MMP-2 and Cyclin D1 Upregulation
Supplementary data
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BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume
Nicholas Theodosakis; Matthew A. Held; Alexander Marzuka-Alcala; Katrina M. Meeth; Goran Micevic; Georgina V. Long; Richard A. Scolyer; David F. Stern; Marcus W. Bosenberg
View articletitled, BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume
Supplementary data
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Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression
Jong Kyu Woo; Ju-Hee Kang; DongYun Shin; Seong-Hyeok Park; Kyungsu Kang; Chu Won Nho; Je Kyung Seong; Sang-Jin Lee; Seung Hyun Oh
View articletitled, Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression
Supplementary data
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Significance of Polypyrimidine Tract–Binding Protein 1 Expression in Colorectal Cancer
Hidekazu Takahashi; Junichi Nishimura; Yoshinori Kagawa; Yoshihiro Kano; Yusuke Takahashi; Xin Wu; Masayuki Hiraki; Atsushi Hamabe; Masamitsu Konno; Naotsugu Haraguchi; Ichiro Takemasa; Tsunekazu Mizushima; Masaru Ishii; Koshi Mimori; Hideshi Ishii; Yuichiro Doki; Masaki Mori; Hirofumi Yamamoto
View articletitled, Significance of Polypyrimidine Tract–Binding Protein 1 Expression in Colorectal Cancer
Supplementary data
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CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis
Daniela Burgos-Ojeda; Rong Wu; Karen McLean; Yu-Chih Chen; Moshe Talpaz; Euisik Yoon; Kathleen R. Cho; Ronald J. Buckanovich
View articletitled, CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis
Supplementary data
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Aromatase Inhibitor–Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer
Raju Khatri; Preeti Shah; Rupa Guha; Feyruz V. Rassool; Alan E. Tomkinson; Angela Brodie; Anil K. Jaiswal
View articletitled, Aromatase Inhibitor–Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer
Supplementary data
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Author Choice
Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells
Kaikai Shen; Jianling Xie; Hua Wang; Hong Zhang; Mengyuan Yu; Fangfang Lu; Hongsheng Tan; Hongxi Xu
View articletitled, Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells
Supplementary data
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MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma
Li Ren Kong; Kian Ngiap Chua; Wen Jing Sim; Hsien Chun Ng; Chonglei Bi; Jingshan Ho; Min En Nga; Yin Huei Pang; Weijie Richard Ong; Ross Andrew Soo; Hung Huynh; Wee Joo Chng; Jean-Paul Thiery; Boon Cher Goh
View articletitled, MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma
Supplementary data
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Corrections

Correction: A Combinatory Strategy for Detection of Live CTCs Using Microfiltration and a New Telomerase-Selective Adenovirus
View articletitled, Correction: A Combinatory Strategy for Detection of Live CTCs Using Microfiltration and a New Telomerase-Selective Adenovirus
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Correction: Synergistic Induction of Apoptosis in Multiple Myeloma Cells by Bortezomib and Hypoxia-Activated Prodrug TH-302, In Vivo and In Vitro
View articletitled, Correction: Synergistic Induction of Apoptosis in Multiple Myeloma Cells by Bortezomib and Hypoxia-Activated Prodrug TH-302, <em>In Vivo</em> and <em>In Vitro</em>
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Correction: In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer
View articletitled, Correction: <em>In Vitro</em> and <em>In Vivo</em> Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer
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  • Online ISSN 1538-8514
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