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Volume 14, Issue 10
1 October 2015
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    Cover Image

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    5-hydroxydecanoate (5-HD) is a potential neuroprotective drug in cortical neurons. Paclitaxel has a potent toxicity on neuron viability, neurite morphology, and synaptic formation. 5-HD, screened from compound libraries, exhibited the most significant neuroprotective effects against paclitaxel-induced neurotoxicity. Using an image-based high-content platform, 5-HD decreased paclitaxel-induced damage to viability, neurite outgrowth, and synaptogenesis in cortical neurons. For details, see the article by Chen and colleagues on page 2206.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Small Molecule Therapeutics

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression
Ryan Lenhart; Stefan Kirov; Heshani Desilva; Jian Cao; Ming Lei; Kathy Johnston; Russell Peterson; Liang Schweizer; Ashok Purandare; Petra Ross-Macdonald; Craig Fairchild; Tai Wong; Susan Wee
View articletitled, Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of <em>ASCL1</em> Gene Expression
Supplementary data
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Assessment of the In Vivo Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal Cancer
Meera Raja; Matt Zverev; Katja Seipel; Geraint T. Williams; Alan R. Clarke; Paul H.S. Shaw
View articletitled, Assessment of the <em>In Vivo</em> Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal Cancer
Supplementary data
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BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers
Zhiyu Tang; Xi Yuan; Rong Du; Shing-Hu Cheung; Guoliang Zhang; Jing Wei; Yuan Zhao; Yingcai Feng; Hao Peng; Yi Zhang; Yunguang Du; Xiaoxia Hu; Wenfeng Gong; Yong Liu; Yajuan Gao; Ye Liu; Rui Hao; Shengjian Li; Shaohui Wang; Jiafu Ji; Lianhai Zhang; Shuangxi Li; David Sutton; Min Wei; Changyou Zhou; Lai Wang; Lusong Luo
View articletitled, BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in <em>BRAF</em>-Mutated Colorectal Cancers
Supplementary data
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Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Takashi Sato; Takeshi Shimosato; Atsuhisa Ueda; Yoshiaki Ishigatsubo; Dennis M. Klinman
View articletitled, Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Supplementary data
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Integrating Image-Based High-Content Screening with Mouse Models Identifies 5-Hydroxydecanoate as a Neuroprotective Drug for Paclitaxel-Induced Neuropathy
Li-Hsien Chen; Yuan-Ting Sun; Yih-Fung Chen; Mei-Yi Lee; Lian-Yun Chang; Jang-Yang Chang; Meng-Ru Shen
View articletitled, Integrating Image-Based High-Content Screening with Mouse Models Identifies 5-Hydroxydecanoate as a Neuroprotective Drug for Paclitaxel-Induced Neuropathy
Supplementary data
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Author Choice
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis
Yuna Guo; S. Ray Kenney; Carolyn Y. Muller; Sarah Adams; Teresa Rutledge; Elsa Romero; Cristina Murray-Krezan; Rytis Prekeris; Larry A. Sklar; Laurie G. Hudson; Angela Wandinger-Ness
View articletitled, R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis
Supplementary data
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Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues
Shaunna L. Beedie; Cody J. Peer; Steven Pisle; Erin R. Gardner; Chris Mahony; Shelby Barnett; Agnieszka Ambrozak; Michael Gütschow; Cindy H. Chau; Neil Vargesson; William D. Figg
View articletitled, Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues
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Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in RET-Rearranged Lung Adenocarcinoma
Chan Woo Kang; Kang Won Jang; Jinyoung Sohn; Sung-Moo Kim; Kyoung-Ho Pyo; Hwan Kim; Mi Ran Yun; Han Na Kang; Hye Ryun Kim; Sun Min Lim; Yong Wha Moon; Soonmyung Paik; Dae Joon Kim; Joo Hang Kim; Byoung Chul Cho
View articletitled, Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in <em>RET</em>-Rearranged Lung Adenocarcinoma
Supplementary data
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Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097
Ellen Weisberg; Ensar Halilovic; Vesselina G. Cooke; Atsushi Nonami; Tao Ren; Takaomi Sanda; Irene Simkin; Jing Yuan; Brandon Antonakos; Louise Barys; Moriko Ito; Richard Stone; Ilene Galinsky; Kristen Cowens; Erik Nelson; Martin Sattler; Sebastien Jeay; Jens U. Wuerthner; Sean M. McDonough; Marion Wiesmann; James D. Griffin
View articletitled, Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097
Supplementary data
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Targeting c-MYC in Platinum-Resistant Ovarian Cancer
Jeyshka M. Reyes-González; Guillermo N. Armaiz-Peña; Lingegowda S. Mangala; Fatma Valiyeva; Cristina Ivan; Sunila Pradeep; Ileabett M. Echevarría-Vargas; Adrian Rivera-Reyes; Anil K. Sood; Pablo E. Vivas-Mejía
View articletitled, Targeting c-MYC in Platinum-Resistant Ovarian Cancer
Supplementary data
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Large Molecule Therapeutics

Author Choice
Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity
Yiyuan Yin; Stevan Djakovic; Scot Marsters; Janet Tien; Jing Peng; Jarrod Tremayne; Genee Lee; Richard M. Neve; Yan Wu; Mark Merchant; Avi Ashkenazi; Paul J. Carter
View articletitled, Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity
Supplementary data
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Gene Knockdown by EpCAM Aptamer–siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells
Adi Gilboa-Geffen; Peter Hamar; Minh T.N. Le; Lee Adam Wheeler; Radiana Trifonova; Fabio Petrocca; Anders Wittrup; Judy Lieberman
View articletitled, Gene Knockdown by EpCAM Aptamer–siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells
Supplementary data
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Cancer Biology and Signal Transduction

Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells
Yeonui Kwak; Hanna Cho; Wooyoung Hur; Taebo Sim
View articletitled, Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells
Supplementary data
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Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs
Shuntaro Tsukamoto; Yuhui Huang; Motofumi Kumazoe; Connie Lesnick; Shuhei Yamada; Naoki Ueda; Takashi Suzuki; Shuya Yamashita; Yoon Hee Kim; Yoshinori Fujimura; Daisuke Miura; Neil E. Kay; Tait D. Shanafelt; Hirofumi Tachibana
View articletitled, Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs
Supplementary data
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miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma
Manchao Zhang; Longzhu Piao; Jharna Datta; James C. Lang; Xiujie Xie; Theodoros N. Teknos; Anna K. Mapp; Quintin Pan
View articletitled, miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma
Supplementary data
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Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition
Adrian P. Wiegmans; Pei-Yi Yap; Ambber Ward; Yi Chieh Lim; Kum Kum Khanna
View articletitled, Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition
Supplementary data
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The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis
Shinichi Kiyonari; Makoto Iimori; Kazuaki Matsuoka; Sugiko Watanabe; Tomomi Morikawa-Ichinose; Daisuke Miura; Shinichiro Niimi; Hiroshi Saeki; Eriko Tokunaga; Eiji Oki; Masaru Morita; Kenji Kadomatsu; Yoshihiko Maehara; Hiroyuki Kitao
View articletitled, The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis
Supplementary data
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Author Choice
Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth
Diana Yi Zhao; Keith M. Jacobs; Dennis E. Hallahan; Dinesh Thotala
View articletitled, Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth
Supplementary data
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Met Signaling Cascade Is Amplified by the Recruitment of Phosphorylated Met to Lipid Rafts via CD24 and Leads to Drug Resistance in Endometrial Cancer Cell Lines
Yoshihiro Joshua Ono; Akiko Tanabe; Tomohito Tanaka; Yoshimichi Tanaka; Masami Hayashi; Yoshito Terai; Masahide Ohmichi
View articletitled, Met Signaling Cascade Is Amplified by the Recruitment of Phosphorylated Met to Lipid Rafts via CD24 and Leads to Drug Resistance in Endometrial Cancer Cell Lines
Supplementary data
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Antileukemic Activity of 2-Deoxy-d-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations
Clément Larrue; Estelle Saland; François Vergez; Nizar Serhan; Eric Delabesse; Véronique Mansat-De Mas; Marie-Anne Hospital; Jérôme Tamburini; Stéphane Manenti; Jean Emmanuel Sarry; Christian Récher
View articletitled, Antileukemic Activity of 2-Deoxy-<span class="small-caps">d</span>-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with <em>FLT3-ITD</em> or <em>c-KIT</em> Mutations
Supplementary data
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Companion Diagnostics and Cancer Biomarkers

Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer
Sebastian Stintzing; Wu Zhang; Volker Heinemann; Daniel Neureiter; Ralf Kemmerling; Thomas Kirchner; Andreas Jung; Matthias Folwaczny; Dongyun Yang; Yan Ning; Ana Sebio; Stefan Stremitzer; Yu Sunakawa; Satoshi Matsusaka; Shinichi Yamauchi; Fotios Loupakis; Chiara Cremolini; Alfredo Falcone; Heinz-Josef Lenz
View articletitled, Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer
Supplementary data
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Models and Technologies

NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy
Chunxiao Xu; Kevin A. Buczkowski; Yanxi Zhang; Hajime Asahina; Ellen M. Beauchamp; Hideki Terai; Yvonne Y. Li; Matthew Meyerson; Kwok-kin Wong; Peter S. Hammerman
View articletitled, NSCLC Driven by <em>DDR2</em> Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy
Supplementary data
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Improvement of Stability and Efficacy of C16Y Therapeutic Peptide via Molecular Self-Assembly into Tumor-Responsive Nanoformulation
Yanping Ding; Tianjiao Ji; Ying Zhao; Yinlong Zhang; Xiaozheng Zhao; Ruifang Zhao; Jiayan Lang; Xiao Zhao; Jian Shi; Saraswati Sukumar; Guangjun Nie
View articletitled, Improvement of Stability and Efficacy of C16Y Therapeutic Peptide via Molecular Self-Assembly into Tumor-Responsive Nanoformulation
Supplementary data
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Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach
Yan Ning; Diana L. Hanna; Wu Zhang; Angela Mendez; Dongyun Yang; Rita El-Khoueiry; Satoshi Matsusaka; Yu Sunakawa; Stefan Stremitzer; Anish Parekh; Satoshi Okazaki; Martin D. Berger; Afsaneh Barzi; Heinz-Josef Lenz
View articletitled, Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach
Supplementary data
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  • Online ISSN 1538-8514
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