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Issues

Volume 13, Issue 7
1 July 2014
Molecular Cancer Therapeutics Cover Image for Volume 13, Issue 7
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  • Cover Image

    Cover Image

    Issue cover image
    Particle replication in nonwetting templates (PRINT) is a novel soft lithography process developed to fabricate nanotherapeutics. PRINT nanoparticles improve plasma exposure and increase tumor accumulation of the encapsulated therapeutic. Metronomic delivery of PLGA-PRINT-docetaxel nanoparticles combined with systemic EZH2 siRNA delivery using chitosan nanoparticles resulted in robust antitumor effects in ovarian cancer mouse models. For details, see the article by Gharpure and colleagues on page 1750.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Small Molecule Therapeutics

Targeting Multiple Key Signaling Pathways in Melanoma Using Leelamine
Raghavendra Gowda; SubbaRao V. Madhunapantula; Omer F. Kuzu; Arati Sharma; Gavin P. Robertson
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Leelamine Mediates Cancer Cell Death through Inhibition of Intracellular Cholesterol Transport
Omer F. Kuzu; Raghavendra Gowda; Arati Sharma; Gavin P. Robertson
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Author Choice
EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis
Ji Yeon Son; So-Yeon Park; Sol-Ji Kim; Seon Joo Lee; Sang-A. Park; Min-Jin Kim; Seung Won Kim; Dae-Kee Kim; Jeong-Seok Nam; Yhun Yhong Sheen
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Geranylgeranylacetone Blocks Doxorubicin-Induced Cardiac Toxicity and Reduces Cancer Cell Growth and Invasion through RHO Pathway Inhibition
Polina Sysa-Shah; Yi Xu; Xin Guo; Scott Pin; Djahida Bedja; Rachel Bartock; Allison Tsao; Angela Hsieh; Michael S. Wolin; An Moens; Venu Raman; Hajime Orita; Kathleen L. Gabrielson
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Anti-miR182 Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An In Vivo Study in Orthotopic Xenografts of Nude Mice
Xiaofei Xu; Bushra Ayub; Zhaojian Liu; Vanida Ann Serna; Wenan Qiang; Yugang Liu; Eva Hernando; Sonya Zabludoff; Takeshi Kurita; Beihua Kong; Jian-Jun Wei
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Combination of Conventional Chemotherapeutics with Redox-Active Cerium Oxide Nanoparticles—A Novel Aspect in Cancer Therapy
Maren Sack; Lirija Alili; Elif Karaman; Soumen Das; Ankur Gupta; Sudipta Seal; Peter Brenneisen
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Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer
Kshipra M. Gharpure; Kevin S. Chu; Charles J. Bowerman; Takahito Miyake; Sunila Pradeep; Selanere L. Mangala; Hee-Dong Han; Rajesha Rupaimoole; Guillermo N. Armaiz-Pena; Tojan B. Rahhal; Sherry Y. Wu; J. Christopher Luft; Mary E. Napier; Gabriel Lopez-Berestein; Joseph M. DeSimone; Anil K. Sood
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Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling
Anamaria Balic; Morten Dræby Sørensen; Sara Maria Trabulo; Bruno Sainz, Jr; Michele Cioffi; Catarina R. Vieira; Irene Miranda-Lorenzo; Manuel Hidalgo; Joerg Kleeff; Mert Erkan; Christopher Heeschen
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Large Molecule Therapeutics

Antibody-Based Delivery of IL2 and Cytotoxics Eradicates Tumors in Immunocompetent Mice
Katrin L. Gutbrodt; Giulio Casi; Dario Neri
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Author Choice
Generation of a Canine Anti-EGFR (ErbB-1) Antibody for Passive Immunotherapy in Dog Cancer Patients
Josef Singer; Judit Fazekas; Wei Wang; Marlene Weichselbaumer; Miroslawa Matz; Alexander Mader; Willibald Steinfellner; Sarah Meitz; Diana Mechtcheriakova; Yuri Sobanov; Michael Willmann; Thomas Stockner; Edzard Spillner; Renate Kunert; Erika Jensen-Jarolim
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Ectodomain-Specific E-Cadherin Antibody Suppresses Skin SCC Growth and Reduces Tumor Grade: A Multitargeted Therapy Modulating RTKs and the PTEN–p53–MDM2 Axis
Sabine M. Brouxhon; Stephanos Kyrkanides; Veena Raja; Andrew Silberfeld; Xiaofei Teng; Denise Trochesset; Jason Cohen; Li Ma
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Author Choice
Preclinical Evaluation of Multistep Targeting of Diasialoganglioside GD2 Using an IgG-scFv Bispecific Antibody with High Affinity for GD2 and DOTA Metal Complex
Sarah M. Cheal; Hong Xu; Hong-fen Guo; Pat B. Zanzonico; Steven M. Larson; Nai-Kong Cheung
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Targeted BikDD Expression Kills Androgen-Dependent and Castration-Resistant Prostate Cancer Cells
Xiaoming Xie; Yanan Kong; Hailin Tang; Lu Yang; Jennifer L. Hsu; Mien-Chie Hung
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Combination of Anti-HER3 Antibody MM-121/SAR256212 and Cetuximab Inhibits Tumor Growth in Preclinical Models of Head and Neck Squamous Cell Carcinoma
Ning Jiang; Dongsheng Wang; Zhongliang Hu; Hyung Ju C. Shin; Guoqing Qian; Mohammad Aminur Rahman; Hongzheng Zhang; A.R.M. Ruhul Amin; Sreenivas Nannapaneni; Xiaojing Wang; Zhengjia Chen; Gabriela Garcia; Gavin MacBeath; Dong M. Shin; Fadlo R. Khuri; Jun Ma; Zhuo G. Chen; Nabil F. Saba
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Cancer Biology and Signal Transduction

PIK3R3 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Colorectal Cancer
Guihua Wang; Xi Yang; Chuan Li; Xiaonian Cao; Xuelai Luo; Junbo Hu
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Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myelogenous Leukemia Cells
Weiguo Zhang; Vivian R. Ruvolo; Chen Gao; Liran Zhou; William Bornmann; Twee Tsao; Wendy D. Schober; Paul Smith; Sylvie Guichard; Marina Konopleva; Michael Andreeff
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Inhibition of SIRT1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo
Zhenxing Liang; Yang Yang; Haibin Wang; Wei Yi; Xiaolong Yan; Juanjuan Yan; Yue Li; Yingtong Feng; Shiqiang Yu; Jian Yang; Zhenxiao Jin; Weixun Duan; Wensheng Chen
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Activation of Liver X Receptors Inhibits Hedgehog Signaling, Clonogenic Growth, and Self-Renewal in Multiple Myeloma
Jasmin R. Agarwal; Qiuju Wang; Toshihiko Tanno; Zeshaan Rasheed; Akil Merchant; Nilanjan Ghosh; Ivan Borrello; Carol Ann Huff; Farhad Parhami; William Matsui
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Preferential Estrogen Receptor β Ligands Reduce Bcl-2 Expression in Hormone-Resistant Breast Cancer Cells to Increase Autophagy
Samantha C. Ruddy; Rosanna Lau; Miguel A. Cabrita; Chelsea McGregor; Bruce C. McKay; Leigh C. Murphy; James S. Wright; Tony Durst; M.A. Christine Pratt
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Phosphoproteomics of MAPK Inhibition in BRAF-Mutated Cells and a Role for the Lethal Synergism of Dual BRAF and CK2 Inhibition
Robert Parker; Roderick Clifton-Bligh; Mark P. Molloy
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BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen
Vaibhav Sahai; Krishan Kumar; Lawrence M. Knab; Christina R. Chow; Sania S. Raza; David J. Bentrem; Kazumi Ebine; Hidayatullah G. Munshi
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A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance
Junfeng Xia; Peilin Jia; Katherine E. Hutchinson; Kimberly B. Dahlman; Douglas Johnson; Jeffrey Sosman; William Pao; Zhongming Zhao
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Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer
Luiz Fernando Zerbini; Manoj K. Bhasin; Jaira F. de Vasconcellos; Juliano D. Paccez; Xuesong Gu; Andrew L. Kung; Towia A. Libermann
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MicroRNA-26b Represses Colon Cancer Cell Proliferation by Inhibiting Lymphoid Enhancer Factor 1 Expression
Zichao Zhang; KyoungHyun Kim; Xiao Li; Myriam Moreno; Thad Sharp; Michael J. Goodheart; Stephen Safe; Adam J. Dupuy; Brad A. Amendt
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Companion Diagnostics and Cancer Biomarkers

Regulation of SRC Kinases by microRNA-3607 Located in a Frequently Deleted Locus in Prostate Cancer
Sharanjot Saini; Shahana Majid; Varahram Shahryari; Z. Laura Tabatabai; Sumit Arora; Soichiro Yamamura; Yuichiro Tanaka; Rajvir Dahiya; Guoren Deng
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Models and Technologies

A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses
Muhammad Kashif; Claes Andersson; Magnus Åberg; Peter Nygren; Tobias Sjöblom; Ulf Hammerling; Rolf Larsson; Mats G. Gustafsson
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