Skip Nav Destination
Issues
1 April 2014
-
Cover Image
Cover Image
![issue cover]()
The cover image shows peptide-targeted SPECT/CT imaging of gliomas. Radiolabeled (indium, 111In) CooP peptide was injected into the tail vein of intracranial U87MG tumor-bearing mice. Two hours after injection, accumulation of the 111In-conjugated CooP peptide was detectable using the SPECT/CT whole-body imaging device in brain tumors (mouse on left), while no control peptide could be detected in the tumors (mouse on right). For details, see article by Hyvönen et al., on page 996.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Small Molecule Therapeutics
Author Choice
Antitumor Effects in Gastrointestinal Stromal Tumors Using Photodynamic Therapy with a Novel Glucose-Conjugated Chlorin
Mamoru Tanaka; Hiromi Kataoka; Shigenobu Yano; Hiromi Ohi; Kazuhiro Moriwaki; Haruo Akashi; Takahiro Taguchi; Noriyuki Hayashi; Shingo Hamano; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Takashi Joh
Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice
Lucie Tumova; Antonio R. Pombinho; Martina Vojtechova; Jitka Stancikova; Dietmar Gradl; Michaela Krausova; Eva Sloncova; Monika Horazna; Vitezslav Kriz; Olga Machonova; Jindrich Jindrich; Zbynek Zdrahal; Petr Bartunek; Vladimir Korinek
Author Choice
Novel ATP-Competitive MEK Inhibitor E6201 Is Effective against Vemurafenib-Resistant Melanoma Harboring the MEK1-C121S Mutation in a Preclinical Model
Yusuke Narita; Kiyoshi Okamoto; Megumi Ikemori Kawada; Kazuma Takase; Yukinori Minoshima; Kotaro Kodama; Masao Iwata; Norimasa Miyamoto; Kohei Sawada
Author Choice
Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
Sarah K. Knutson; Satoshi Kawano; Yukinori Minoshima; Natalie M. Warholic; Kuan-Chun Huang; Yonghong Xiao; Tadashi Kadowaki; Mai Uesugi; Galina Kuznetsov; Namita Kumar; Tim J. Wigle; Christine R. Klaus; Christina J. Allain; Alejandra Raimondi; Nigel J. Waters; Jesse J. Smith; Margaret Porter-Scott; Richard Chesworth; Mikel P. Moyer; Robert A. Copeland; Victoria M. Richon; Toshimitsu Uenaka; Roy M. Pollock; Kevin W. Kuntz; Akira Yokoi; Heike Keilhack
Author Choice
Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models
Christopher A. Benetatos; Yasuhiro Mitsuuchi; Jennifer M. Burns; Eric M. Neiman; Stephen M. Condon; Guangyao Yu; Martin E. Seipel; Gurpreet S. Kapoor; Matthew G. LaPorte; Susan R. Rippin; Yijun Deng; Mukta S. Hendi; Pavan K. Tirunahari; Yu-Hua Lee; Thomas Haimowitz; Matthew D. Alexander; Martin A. Graham; David Weng; Yigong Shi; Mark A. McKinlay; Srinivas K. Chunduru
Author Choice
Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
Kathleen Keegan; Cong Li; Zhihong Li; Ji Ma; Mark Ragains; Suzanne Coberly; David Hollenback; John Eksterowicz; Lingming Liang; Margaret Weidner; Justin Huard; Xianghong Wang; Grace Alba; Jessica Orf; Mei-Chu Lo; Sharon Zhao; Rachel Ngo; Ada Chen; Lily Liu; Timothy Carlson; Christophe Quéva; Lawrence R. McGee; Julio Medina; Alexander Kamb; Dineli Wickramasinghe; Kang Dai
Author Choice
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
Matt I. Gross; Susan D. Demo; Jennifer B. Dennison; Lijing Chen; Tania Chernov-Rogan; Bindu Goyal; Julie R. Janes; Guy J. Laidig; Evan R. Lewis; Jim Li; Andrew L. MacKinnon; Francesco Parlati; Mirna L.M. Rodriguez; Peter J. Shwonek; Eric B. Sjogren; Timothy F. Stanton; Taotao Wang; Jinfu Yang; Frances Zhao; Mark K. Bennett
Large Molecule Therapeutics
Author Choice
Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer
Maoyong Fu; Erin L. Maresh; Gustavo F. Helguera; Meagan Kiyohara; Yu Qin; Negin Ashki; Tracy R. Daniels-Wells; Najib Aziz; Lynn K. Gordon; Jonathan Braun; Yahya Elshimali; Robert A. Soslow; Manuel L. Penichet; Lee Goodglick; Madhuri Wadehra
Inhibition of Tumor Growth and Angiogenesis by SP-2, an Anti–Lectin, Galactoside-Binding Soluble 3 Binding Protein (LGALS3BP) Antibody
Sara Traini; Enza Piccolo; Nicola Tinari; Cosmo Rossi; Rossana La Sorda; Francesca Spinella; Anna Bagnato; Rossano Lattanzio; Maurizia D'Egidio; Annalisa Di Risio; Federica Tomao; Antonino Grassadonia; Mauro Piantelli; Clara Natoli; Stefano Iacobelli
Cancer Biology and Signal Transduction
PP2A Inhibition Is a Common Event in Colorectal Cancer and Its Restoration Using FTY720 Shows Promising Therapeutic Potential
Ion Cristóbal; Rebeca Manso; Raúl Rincón; Cristina Caramés; Clara Senin; Aurea Borrero; Javier Martínez-Useros; María Rodriguez; Sandra Zazo; Oscar Aguilera; Juan Madoz-Gúrpide; Federico Rojo; Jesús García-Foncillas
Companion Diagnostic and Cancer Biomarkers
Author Choice
Decreased miR-340 Expression in Bone Marrow Is Associated with Liver Metastasis of Colorectal Cancer
Hiroshi Takeyama; Hirofumi Yamamoto; Shinya Yamashita; Xin Wu; Hidekazu Takahashi; Junichi Nishimura; Naotsugu Haraguchi; Yasuhiro Miyake; Rei Suzuki; Kohei Murata; Masayuki Ohue; Takeshi Kato; Ichiro Takemasa; Tsunekazu Mizushima; Hideshi Ishii; Koshi Mimori; Yuichiro Doki; Masaki Mori
Models and Technologies
Advertisement
