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1 January 2013
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Cover Image
Cover Image
RING finger proteins are involved in numerous cancer-related processes such as cell cycle, apoptosis, and DNA repair. Knockdown of RNF43, a recently identified new member of Ring finger family, inhibited both growth and invasion of HCC cells. Immunofluorescence showed that after RNF43 knockdown, the stress fiber formation of HCC cells was suppressed compared with control group and this was coincident with decreased cell migration ability. For details, see article by Xing and colleagues on page 94. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Research Articles
Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Mark Sutherland; Jason H. Gill; Paul M. Loadman; Jonathan P. Laye; Helen M. Sheldrake; Nicola A. Illingworth; Mohammed N. Alandas; Patricia A. Cooper; Mark Searcey; Klaus Pors; Steve D. Shnyder; Laurence H. Patterson
Large Molecule Therapeutics Discovery & Preclinical Development
Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells
Puja Sapra; Marc Damelin; John DiJoseph; Kimberly Marquette; Kenneth G. Geles; Jonathon Golas; Maureen Dougher; Bitha Narayanan; Andreas Giannakou; Kiran Khandke; Russell Dushin; Elana Ernstoff; Judy Lucas; Mauricio Leal; George Hu; Christopher J. O'Donnell; Lioudmila Tchistiakova; Robert T. Abraham; Hans-Peter Gerber
Cancer Therapeutics Insights
Companion Diagnostics & Cancer Biomarkers
Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
David W. Craig; Joyce A. O'Shaughnessy; Jeffrey A. Kiefer; Jessica Aldrich; Shripad Sinari; Tracy M. Moses; Shukmei Wong; Jennifer Dinh; Alexis Christoforides; Joanne L. Blum; Cristi L. Aitelli; Cynthia R. Osborne; Tyler Izatt; Ahmet Kurdoglu; Angela Baker; Julie Koeman; Catalin Barbacioru; Onur Sakarya; Francisco M. De La Vega; Asim Siddiqui; Linh Hoang; Paul R. Billings; Bodour Salhia; Anthony W. Tolcher; Jeffrey M. Trent; Spyro Mousses; Daniel Von Hoff; John D. Carpten
Correction
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