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Volume 11, Issue 7
1 July 2012
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    Cover Image

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    Deregulation of TGF-β superfamily signaling is a causative factor in many diseases. Bivalent single-chain traps that neutralize TGF-β family ligands (green and orange) were rationally designed using native intrinsically disordered regions as linkers (black) between two cognate receptor binding domains (magenta). TGF-β traps designed by this innovative strategy can achieve similar or better in vitro potency and in vivo tumor growth inhibition compared to a neutralizing antibody, indicating their promising therapeutic potential. For details, see article by Zwaagstra and colleagues on page 1477.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Spotlight on Clinical Response

Early FDG/PET Scanning as a Pharmacodynamic Marker of Anti-EGFR Antibody Activity in Colorectal Cancer
Geoffrey W. Krystal; Erin Alesi; James L. Tatum
View articletitled, Early FDG/PET Scanning as a Pharmacodynamic Marker of Anti-EGFR Antibody Activity in Colorectal Cancer
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Therapeutic Discovery

Inducible Silencing of Protein Kinase D3 Inhibits Secretion of Tumor-Promoting Factors in Prostate Cancer
Courtney R. LaValle; Liyong Zhang; Shuping Xu; Julie L. Eiseman; Q. Jane Wang
View articletitled, Inducible Silencing of Protein Kinase D3 Inhibits Secretion of Tumor-Promoting Factors in Prostate Cancer
Supplementary data
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Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics
Weizao Chen; Yang Feng; Qi Zhao; Zhongyu Zhu; Dimiter S. Dimitrov
View articletitled, Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics
Supplementary data
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ErbB3 Inhibitory Surrobodies Inhibit Tumor Cell Proliferation In Vitro and In Vivo
Pamela K. Foreman; Medini Gore; Philip A. Kobel; Li Xu; Helena Yee; Charles Hannum; Hoangdung Ho; Sandra M. Wang; Hieu V. Tran; Michael Horowitz; Lawrence Horowitz; Ramesh R. Bhatt
View articletitled, ErbB3 Inhibitory Surrobodies Inhibit Tumor Cell Proliferation <em>In Vitro</em> and <em>In Vivo</em>
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Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer
Xinyi Liu; Indira Jutooru; Ping Lei; KyoungHyun Kim; Syng-ook Lee; Lisa K. Brents; Paul L. Prather; Stephen Safe
View articletitled, Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer
Supplementary data
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Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening
Richard J. Rickles; Winnie F. Tam; Thomas P. Giordano, III; Laura T. Pierce; Melissa Farwell; Douglas W. McMillin; Antoaneta Necheva; David Crowe; Mei Chen; William Avery; Vikram Kansra; Steffan T. Nawrocki; Jennifer S. Carew; Francis J. Giles; Constantine S. Mitsiades; Alexis A. Borisy; Kenneth C. Anderson; Margaret S. Lee
View articletitled, Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening
Supplementary data
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Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents In Vitro and In Vivo
Hui-Chun Wang; Alan Yueh-Luen Lee; Wen-Cheng Chou; Chin-Chung Wu; Chao-Neng Tseng; Kevin Yen-Ting Liu; Wen-Lien Lin; Fang-Rong Chang; Da-Wei Chuang; Attila Hunyadi; Yang-Chang Wu
View articletitled, Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents <em>In Vitro</em> and <em>In Vivo</em>
Supplementary data
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microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
Huanyu Zhang; Meng Qi; Shiwang Li; Teng Qi; Hong Mei; Kai Huang; Liduan Zheng; Qiangsong Tong
View articletitled, microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
Supplementary data
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Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Yu Zhou; Anne-Laure Goenaga; Brian D. Harms; Hao Zou; Jianlong Lou; Fraser Conrad; Gregory P. Adams; Birgit Schoeberl; Ulrik B. Nielsen; James D. Marks
View articletitled, Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Supplementary data
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Engineering and Therapeutic Application of Single-Chain Bivalent TGF-β Family Traps
John C. Zwaagstra; Traian Sulea; Jason Baardsnes; Anne E.G. Lenferink; Cathy Collins; Christiane Cantin; Béatrice Paul-Roc; Suzanne Grothe; Sazzad Hossain; Louis-Philippe Richer; Denis L'Abbé; Roseanne Tom; Brian Cass; Yves Durocher; Maureen D. O'Connor-McCourt
View articletitled, Engineering and Therapeutic Application of Single-Chain Bivalent TGF-β Family Traps
Supplementary data
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Preclinical Development

Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells
C. Elizabeth Caldon; C. Marcelo Sergio; Jian Kang; Anita Muthukaruppan; Marijke N. Boersma; Andrew Stone; Jane Barraclough; Christine S. Lee; Michael A. Black; Lance D. Miller; Julia M. Gee; Rob I. Nicholson; Robert L. Sutherland; Cristin G. Print; Elizabeth A. Musgrove
View articletitled, Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells
Supplementary data
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Characterization of an Oxaliplatin Sensitivity Predictor in a Preclinical Murine Model of Colorectal Cancer
Mickey K. Kim; Takuya Osada; William T. Barry; Xiao Yi Yang; Jennifer A. Freedman; Katherine A. Tsamis; Michael Datto; Bryan M. Clary; Timothy Clay; Michael A. Morse; Philip G. Febbo; H. Kim Lyerly; David S. Hsu
View articletitled, Characterization of an Oxaliplatin Sensitivity Predictor in a Preclinical Murine Model of Colorectal Cancer
Supplementary data
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Modulation of Akt/mTOR Signaling Overcomes Sunitinib Resistance in Renal and Prostate Cancer Cells
Peter B. Makhov; Konstantin Golovine; Alexander Kutikov; Ervin Teper; Daniel J. Canter; Jay Simhan; Robert G. Uzzo; Vladimir M. Kolenko
View articletitled, Modulation of Akt/mTOR Signaling Overcomes Sunitinib Resistance in Renal and Prostate Cancer Cells
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XIAP Inhibition and Generation of Reactive Oxygen Species Enhances TRAIL Sensitivity in Inflammatory Breast Cancer Cells
Jennifer L. Allensworth; Katherine M. Aird; Amy J. Aldrich; Ines Batinic-Haberle; Gayathri R. Devi
View articletitled, XIAP Inhibition and Generation of Reactive Oxygen Species Enhances TRAIL Sensitivity in Inflammatory Breast Cancer Cells
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Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas
Giuliana Cavalloni; Caterina Peraldo-Neia; Ivana Sarotto; Loretta Gammaitoni; Giorgia Migliardi; Marco Soster; Serena Marchiò; Massimo Aglietta; Francesco Leone
View articletitled, Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas
Supplementary data
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Effect of a Low-Fat Diet Combined with IGF-1 Receptor Blockade on 22Rv1 Prostate Cancer Xenografts
Ramdev Konijeti; Satomi Koyama; Ashley Gray; R. James Barnard; Jonathan W. Said; Brandon Castor; David Elashoff; Junxiang Wan; Pedro J. Beltran; Frank J. Calzone; Pinchas Cohen; Colette Galet; William J. Aronson
View articletitled, Effect of a Low-Fat Diet Combined with IGF-1 Receptor Blockade on 22Rv1 Prostate Cancer Xenografts
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Thermal Targeting of an Acid-Sensitive Doxorubicin Conjugate of Elastin-like Polypeptide Enhances the Therapeutic Efficacy Compared with the Parent Compound In Vivo
Shama Moktan; Eddie Perkins; Felix Kratz; Drazen Raucher
View articletitled, Thermal Targeting of an Acid-Sensitive Doxorubicin Conjugate of Elastin-like Polypeptide Enhances the Therapeutic Efficacy Compared with the Parent Compound <em>In Vivo</em>
Supplementary data
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Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification
Wataru Okamoto; Isamu Okamoto; Tokuzo Arao; Kiyoko Kuwata; Erina Hatashita; Haruka Yamaguchi; Kazuko Sakai; Kazuyoshi Yanagihara; Kazuto Nishio; Kazuhiko Nakagawa
View articletitled, Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for <em>MET</em> Amplification
Supplementary data
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Preclinical Analysis of the γ-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia
Jeremy B. Samon; Mireia Castillo-Martin; Michael Hadler; Alberto Ambesi-Impiobato; Elisabeth Paietta; Janis Racevskis; Peter H. Wiernik; Jacob M. Rowe; John Jakubczak; Sophia Randolph; Carlos Cordon-Cardo; Adolfo A. Ferrando
View articletitled, Preclinical Analysis of the γ-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia
Supplementary data
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Targeting the Insulin Growth Factor and the Vascular Endothelial Growth Factor Pathways in Ovarian Cancer
Minghai Shao; Stacy Hollar; Daphne Chambliss; Jordan Schmitt; Robert Emerson; Bhadrani Chelladurai; Susan Perkins; Mircea Ivan; Daniela Matei
View articletitled, Targeting the Insulin Growth Factor and the Vascular Endothelial Growth Factor Pathways in Ovarian Cancer
Supplementary data
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Smoothened Antagonists Reverse Taxane Resistance in Ovarian Cancer
Adam D. Steg; Ashwini A. Katre; Kerri S. Bevis; Angela Ziebarth; Zachary C. Dobbin; Monjri M. Shah; Ronald D. Alvarez; Charles N. Landen
View articletitled, Smoothened Antagonists Reverse Taxane Resistance in Ovarian Cancer
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CDK-4 Inhibitor P276 Sensitizes Pancreatic Cancer Cells to Gemcitabine-Induced Apoptosis
Dharmalingam Subramaniam; Giridharan Periyasamy; Sivapriya Ponnurangam; Debarshi Chakrabarti; Aravind Sugumar; Muralidhara Padigaru; Scott J. Weir; Arun Balakrishnan; Somesh Sharma; Shrikant Anant
View articletitled, CDK-4 Inhibitor P276 Sensitizes Pancreatic Cancer Cells to Gemcitabine-Induced Apoptosis
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Molecular Medicine in Practice

The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
Craig P. Carden; Adam Stewart; Parames Thavasu; Emma Kipps; Lorna Pope; Mateus Crespo; Susana Miranda; Gerhardt Attard; Michelle D. Garrett; Paul A. Clarke; Paul Workman; Johann S. de Bono; Martin Gore; Stan B Kaye; Udai Banerji
View articletitled, The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
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