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Volume 11, Issue 2
1 February 2012
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    The relationship between osteoblastic and granulocytic cell differentiation mediated by osteoblast secretion of FGF8f. Retinoic acid (RA)-induced FGF8f directly mediates osteosarcoma U2OS cell differentiation in an autocrine manner. Simultaneously, paracrine FGF8f, secreted into osteoblastic cell-conditioned medium by U2OS cells treated with RA or transduced with phosphorylation-defective RARa or FGF8f, bypasses RA stimuli to inhibit proliferation and induce granulocytic differentiation of RA-sensitive or RA-resistant leukemic myeloblasts at the paracrine level. For details, see article by Chaudhry and colleagues on page 267.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Review

Rationale Behind Targeting Fibroblast Activation Protein–Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy
W. Nathaniel Brennen; John T. Isaacs; Samuel R. Denmeade
View articletitled, Rationale Behind Targeting Fibroblast Activation Protein–Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy
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Therapeutic Discovery

Retinoid-Regulated FGF8f Secretion by Osteoblasts Bypasses Retinoid Stimuli to Mediate Granulocytic Differentiation of Myeloid Leukemia Cells
Parvesh Chaudhry; Xiaochun Yang; Michael Wagner; Ambrose Jong; Lingtao Wu
View articletitled, Retinoid-Regulated FGF8f Secretion by Osteoblasts Bypasses Retinoid Stimuli to Mediate Granulocytic Differentiation of Myeloid Leukemia Cells
Supplementary data
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Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer
Jing Chen; Jieqiong Wang; Lei Lin; Lijun He; Yuanyuan Wu; Li Zhang; Zhengfang Yi; Yihua Chen; Xiufeng Pang; Mingyao Liu
View articletitled, Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer
Supplementary data
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Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy
Fadila Guessous; Yanzhi Yang; Elizabeth Johnson; Lukasz Marcinkiewicz; Matthew Smith; Ying Zhang; Alexander Kofman; David Schiff; James Christensen; Roger Abounader
View articletitled, Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy
Supplementary data
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An Anti-Wnt5a Antibody Suppresses Metastasis of Gastric Cancer Cells In Vivo by Inhibiting Receptor-Mediated Endocytosis
Hideaki Hanaki; Hideki Yamamoto; Hiroshi Sakane; Shinji Matsumoto; Hideki Ohdan; Akira Sato; Akira Kikuchi
View articletitled, An Anti-Wnt5a Antibody Suppresses Metastasis of Gastric Cancer Cells <em>In Vivo</em> by Inhibiting Receptor-Mediated Endocytosis
Supplementary data
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Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors
Razelle Kurzrock; Nash Gabrail; Chandtip Chandhasin; Stacy Moulder; Carrie Smith; Andrew Brenner; Kamalesh Sankhala; Alain Mita; Kelly Elian; Danielle Bouchard; John Sarantopoulos
View articletitled, Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors
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Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Sauveur-Michel Maira; Sabina Pecchi; Alan Huang; Matthew Burger; Mark Knapp; Dario Sterker; Christian Schnell; Daniel Guthy; Tobi Nagel; Marion Wiesmann; Saskia Brachmann; Christine Fritsch; Marion Dorsch; Patrick Chène; Kevin Shoemaker; Alain De Pover; Daniel Menezes; Georg Martiny-Baron; Doriano Fabbro; Christopher J. Wilson; Robert Schlegel; Francesco Hofmann; Carlos García-Echeverría; William R. Sellers; Charles F. Voliva
View articletitled, Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Supplementary data
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Identification of Docetaxel Resistance Genes in Castration-Resistant Prostate Cancer
Mercedes Marín-Aguilera; Jordi Codony-Servat; Susana G. Kalko; Pedro L. Fernández; Raquel Bermudo; Elvira Buxo; María José Ribal; Pedro Gascón; Begoña Mellado
View articletitled, Identification of Docetaxel Resistance Genes in Castration-Resistant Prostate Cancer
Supplementary data
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Therapeutic Mechanism and Efficacy of the Antibody–Drug Conjugate BAY 79-4620 Targeting Human Carbonic Anhydrase 9
Heike M. Petrul; Christoph A. Schatz; Charlotte C. Kopitz; Lila Adnane; Timothy J. McCabe; Pamela Trail; Sha Ha; Yong S. Chang; Andrei Voznesensky; Gerald Ranges; Paul P. Tamburini
View articletitled, Therapeutic Mechanism and Efficacy of the Antibody–Drug Conjugate BAY 79-4620 Targeting Human Carbonic Anhydrase 9
Supplementary data
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Plumbagin Inhibits Osteoclastogenesis and Reduces Human Breast Cancer-Induced Osteolytic Bone Metastasis in Mice through Suppression of RANKL Signaling
Bokyung Sung; Babatunde Oyajobi; Bharat B. Aggarwal
View articletitled, Plumbagin Inhibits Osteoclastogenesis and Reduces Human Breast Cancer-Induced Osteolytic Bone Metastasis in Mice through Suppression of RANKL Signaling
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Preclinical Development

MEK1/2 Inhibitor Selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15–Dependent Manner in a Mouse Xenograft Model
Chandra Bartholomeusz; Tetsuro Oishi; Hitomi Saso; Ugur Akar; Ping Liu; Kimie Kondo; Anna Kazansky; Savitri Krishnamurthy; Jangsoon Lee; Francisco J. Esteva; Junzo Kigawa; Naoto T. Ueno
View articletitled, MEK1/2 Inhibitor Selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15–Dependent Manner in a Mouse Xenograft Model
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DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer
Min Chen; Daniel Shabashvili; Akbar Nawab; Sherry X. Yang; Lisa M. Dyer; Kevin D. Brown; Melinda Hollingshead; Kent W. Hunter; Frederic J. Kaye; Steven N. Hochwald; Victor E. Marquez; Patricia Steeg; Maria Zajac-Kaye
View articletitled, DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer
Supplementary data
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Vascular Disruption in Combination with mTOR Inhibition in Renal Cell Carcinoma
Leigh Ellis; Preeti Shah; Hans Hammers; Kristin Lehet; Paula Sotomayor; Gissou Azabdaftari; Mukund Seshadri; Roberto Pili
View articletitled, Vascular Disruption in Combination with mTOR Inhibition in Renal Cell Carcinoma
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βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells
Arun Kanakkanthara; Peter T. Northcote; John H. Miller
View articletitled, βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells
Supplementary data
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Dual Combination Therapy Targeting DR5 and EMMPRIN in Pancreatic Adenocarcinoma
Hyunki Kim; Guihua Zhai; Sharon L. Samuel; Christopher J. Rigell; Heidi R. Umphrey; Samir Rana; Cecil R. Stockard; Naomi S. Fineberg; Kurt R. Zinn
View articletitled, Dual Combination Therapy Targeting DR5 and EMMPRIN in Pancreatic Adenocarcinoma
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Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
Jiqin Lian; Zhenhong Ni; Xufang Dai; Chang Su; Amber Rae Smith; Liang Xu; Fengtian He
View articletitled, Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
Supplementary data
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Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and Antimetabolites
Ryan Montano; Injae Chung; Kristen M. Garner; David Parry; Alan Eastman
View articletitled, Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and Antimetabolites
Supplementary data
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Evaluation of the Antitumor Effects and Mechanisms of PF00299804, a Pan-HER Inhibitor, Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer
Hyun-Jin Nam; Keith A. Ching; Julie Kan; Hwang-Phill Kim; Sae-Won Han; Seock-Ah Im; Tae-You Kim; James G. Christensen; Do-Youn Oh; Yung-Jue Bang
View articletitled, Evaluation of the Antitumor Effects and Mechanisms of PF00299804, a Pan-HER Inhibitor, Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer
Supplementary data
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Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1–Mediated Inhibition of STAT3
Wei-Tien Tai; Ann-Lii Cheng; Chung-Wai Shiau; Chun-Yu Liu; Ching-Huai Ko; Mai-Wei Lin; Pei-Jer Chen; Kuen-Feng Chen
View articletitled, Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1–Mediated Inhibition of STAT3
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Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Adriana Priscila Trapé; Maria Lucia Hirata Katayama; Rosimeire Aparecida Roela; Helena Brentani; Graziela Rosa Ravacci; Leandro de Araujo Lima; Maria Mitzi Brentani
View articletitled, Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Supplementary data
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Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy
Weiwen Ying; Zhenjian Du; Lijun Sun; Kevin P. Foley; David A. Proia; Ronald K. Blackman; Dan Zhou; Takayo Inoue; Noriaki Tatsuta; Jim Sang; Shuxia Ye; Jamie Acquaviva; Luisa Shin Ogawa; Yumiko Wada; James Barsoum; Keizo Koya
View articletitled, Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy
Supplementary data
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Molecular Medicine in Practice

Coexistence of PIK3CA and Other Oncogene Mutations in Lung Adenocarcinoma–Rationale for Comprehensive Mutation Profiling
Jamie E. Chaft; Maria E. Arcila; Paul K. Paik; Christopher Lau; Gregory J. Riely; M. Catherine Pietanza; Maureen F. Zakowski; Valerie Rusch; Camelia S. Sima; Marc Ladanyi; Mark G. Kris
View articletitled, Coexistence of <em>PIK3CA</em> and Other Oncogene Mutations in Lung Adenocarcinoma–Rationale for Comprehensive Mutation Profiling
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Treatment-Related Protein Biomarker Expression Differs between Primary and Recurrent Ovarian Carcinomas
Deborah A. Zajchowski; Beth Y. Karlan; Laura K. Shawver
View articletitled, Treatment-Related Protein Biomarker Expression Differs between Primary and Recurrent Ovarian Carcinomas
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Epithelial–Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines
Hui Zhao; Vidhi Desai; Jian Wang; David M. Epstein; Mark Miglarese; Elizabeth Buck
View articletitled, Epithelial–Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines
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