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1 February 2012
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Cover Image
Cover Image
The relationship between osteoblastic and granulocytic cell differentiation mediated by osteoblast secretion of FGF8f. Retinoic acid (RA)-induced FGF8f directly mediates osteosarcoma U2OS cell differentiation in an autocrine manner. Simultaneously, paracrine FGF8f, secreted into osteoblastic cell-conditioned medium by U2OS cells treated with RA or transduced with phosphorylation-defective RARa or FGF8f, bypasses RA stimuli to inhibit proliferation and induce granulocytic differentiation of RA-sensitive or RA-resistant leukemic myeloblasts at the paracrine level. For details, see article by Chaudhry and colleagues on page 267.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Therapeutic Discovery
Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors
Razelle Kurzrock; Nash Gabrail; Chandtip Chandhasin; Stacy Moulder; Carrie Smith; Andrew Brenner; Kamalesh Sankhala; Alain Mita; Kelly Elian; Danielle Bouchard; John Sarantopoulos
Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Sauveur-Michel Maira; Sabina Pecchi; Alan Huang; Matthew Burger; Mark Knapp; Dario Sterker; Christian Schnell; Daniel Guthy; Tobi Nagel; Marion Wiesmann; Saskia Brachmann; Christine Fritsch; Marion Dorsch; Patrick Chène; Kevin Shoemaker; Alain De Pover; Daniel Menezes; Georg Martiny-Baron; Doriano Fabbro; Christopher J. Wilson; Robert Schlegel; Francesco Hofmann; Carlos García-Echeverría; William R. Sellers; Charles F. Voliva
Preclinical Development
MEK1/2 Inhibitor Selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15–Dependent Manner in a Mouse Xenograft Model
Chandra Bartholomeusz; Tetsuro Oishi; Hitomi Saso; Ugur Akar; Ping Liu; Kimie Kondo; Anna Kazansky; Savitri Krishnamurthy; Jangsoon Lee; Francisco J. Esteva; Junzo Kigawa; Naoto T. Ueno
DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer
Min Chen; Daniel Shabashvili; Akbar Nawab; Sherry X. Yang; Lisa M. Dyer; Kevin D. Brown; Melinda Hollingshead; Kent W. Hunter; Frederic J. Kaye; Steven N. Hochwald; Victor E. Marquez; Patricia Steeg; Maria Zajac-Kaye
Evaluation of the Antitumor Effects and Mechanisms of PF00299804, a Pan-HER Inhibitor, Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer
Hyun-Jin Nam; Keith A. Ching; Julie Kan; Hwang-Phill Kim; Sae-Won Han; Seock-Ah Im; Tae-You Kim; James G. Christensen; Do-Youn Oh; Yung-Jue Bang
Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Adriana Priscila Trapé; Maria Lucia Hirata Katayama; Rosimeire Aparecida Roela; Helena Brentani; Graziela Rosa Ravacci; Leandro de Araujo Lima; Maria Mitzi Brentani
Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy
Weiwen Ying; Zhenjian Du; Lijun Sun; Kevin P. Foley; David A. Proia; Ronald K. Blackman; Dan Zhou; Takayo Inoue; Noriaki Tatsuta; Jim Sang; Shuxia Ye; Jamie Acquaviva; Luisa Shin Ogawa; Yumiko Wada; James Barsoum; Keizo Koya
Molecular Medicine in Practice
Coexistence of PIK3CA and Other Oncogene Mutations in Lung Adenocarcinoma–Rationale for Comprehensive Mutation Profiling
Jamie E. Chaft; Maria E. Arcila; Paul K. Paik; Christopher Lau; Gregory J. Riely; M. Catherine Pietanza; Maureen F. Zakowski; Valerie Rusch; Camelia S. Sima; Marc Ladanyi; Mark G. Kris
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