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Volume 11, Issue 1
1 January 2012
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    Cover Image

    issue cover
    Pancreatic cancer is extremely lethal, partially due to the aggressive nature of the disease and the lack of reliable markers for early detection. Mucin 13 (MUC13) was found to be overexpressed in pancreatic cancer tissue samples. In in vitro studies, the expression of MUC13 increased the oncogenic characteristics of pancreatic cancer cells, including increased cell proliferation, invasion, and modulation of tumorigenic signaling pathways. Exogenous MUC13 expression also increased tumorigenesis in a mouse model of pancreatic cancer. For details, see article by Chauhan and colleagues on page 24.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Reviews

TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies
Christian T. Hellwig; Markus Rehm
View articletitled, TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies
Supplementary data
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Oncogenic Viruses and Tumor Glucose Metabolism: Like Kids in a Candy Store
Evan Noch; Kamel Khalili
View articletitled, Oncogenic Viruses and Tumor Glucose Metabolism: Like Kids in a Candy Store
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Therapeutic Discovery

MUC13 Mucin Augments Pancreatic Tumorigenesis
Subhash C. Chauhan; Mara C. Ebeling; Diane M. Maher; Michael D. Koch; Akira Watanabe; Hiroyuki Aburatani; Yuhlong Lio; Meena Jaggi
View articletitled, MUC13 Mucin Augments Pancreatic Tumorigenesis
Supplementary data
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A 71-Gene Signature of TRAIL Sensitivity in Cancer Cells
Jun-Jie Chen; Steen Knudsen; Wiktor Mazin; Jesper Dahlgaard; Baolin Zhang
View articletitled, A 71-Gene Signature of TRAIL Sensitivity in Cancer Cells
Supplementary data
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Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells
Yan Liu; Shi-Yong Sun; Taofeek K. Owonikoko; Gabriel L. Sica; Walter J. Curran; Fadlo R. Khuri; Xingming Deng
View articletitled, Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells
Supplementary data
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Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier
Allison Rohner; Mary E. Spilker; Justine L. Lam; Bernadette Pascual; Darian Bartkowski; Qing John Li; Amy H. Yang; Greg Stevens; Meirong Xu; Peter A. Wells; Simon Planken; Sajiv Nair; Shaoxian Sun
View articletitled, Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier
Supplementary data
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Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia
Kara C. Sedoris; Shelia D. Thomas; Cortney R. Clarkson; David Muench; Ashraful Islam; Rajesh Singh; Donald M. Miller
View articletitled, Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia
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A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Ankur Sharma; Anurag N. Paranjape; Annapoorni Rangarajan; Rajan R. Dighe
View articletitled, A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Supplementary data
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SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer
Rusha Thomas; Nima Sharifi
View articletitled, SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer
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Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival
Deborah Wilsker; Jon H. Chung; Ivan Pradilla; Eva Petermann; Thomas Helleday; Fred Bunz
View articletitled, Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival
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Aryl Hydrocarbon Receptor Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells
Shu Zhang; KyoungHyun Kim; Un Ho Jin; Catherine Pfent; Huojun Cao; Brad Amendt; Xinyi Liu; Heather Wilson-Robles; Stephen Safe
View articletitled, Aryl Hydrocarbon Receptor Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells
Supplementary data
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Preclinical Development

A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Wendy L. Allen; Leanne Stevenson; Vicky M. Coyle; Puthen V. Jithesh; Irina Proutski; Gail Carson; Michael A. Gordon; Heinz-Josef D. Lenz; Sandra Van Schaeybroeck; Daniel B. Longley; Patrick G. Johnston
View articletitled, A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary data
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Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity In Vivo
Amit Budhraja; Ning Gao; Zhuo Zhang; Young-Ok Son; Senping Cheng; Xin Wang; Songze Ding; Andrew Hitron; Gang Chen; Jia Luo; Xianglin Shi
View articletitled, Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity <em>In Vivo</em>
Supplementary data
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Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Yu Cao; James D. Marks; Qian Huang; Stephen I. Rudnick; Chiyi Xiong; Walter N. Hittelman; Xiaoxia Wen; John W. Marks; Lawrence H. Cheung; Kim Boland; Chun Li; Gregory P. Adams; Michael G. Rosenblum
View articletitled, Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary data
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MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis
Yan Cheng; Yi Zhang; Li Zhang; Xingcong Ren; Kathryn J. Huber-Keener; Xiaoyuan Liu; Lei Zhou; Jason Liao; Heike Keihack; Li Yan; Eric Rubin; Jin-Ming Yang
View articletitled, MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis
Supplementary data
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A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists
Venugopal Chenna; Chaoxin Hu; Dipankar Pramanik; Blake T. Aftab; Collins Karikari; Nathaniel R. Campbell; Seung-Mo Hong; Ming Zhao; Michelle A. Rudek; Saeed R. Khan; Charles M. Rudin; Anirban Maitra
View articletitled, A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists
Supplementary data
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MK1775, a Selective Wee1 Inhibitor, Shows Single-Agent Antitumor Activity against Sarcoma Cells
Jenny M. Kreahling; Jennifer Y. Gemmer; Damon Reed; Douglas Letson; Marilyn Bui; Soner Altiok
View articletitled, MK1775, a Selective Wee1 Inhibitor, Shows Single-Agent Antitumor Activity against Sarcoma Cells
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Induction of Vascular Endothelial Growth Factor Secretion by Childhood Acute Lymphoblastic Leukemia Cells via the FLT-3 Signaling Pathway
Ana Markovic; Karen L. MacKenzie; Richard B. Lock
View articletitled, Induction of Vascular Endothelial Growth Factor Secretion by Childhood Acute Lymphoblastic Leukemia Cells via the FLT-3 Signaling Pathway
Supplementary data
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In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF-κB Signaling
Karen A. Nolan; Mark S. Dunstan; Mary C. Caraher; Katherine A. Scott; David Leys; Ian J. Stratford
View articletitled, <em>In Silico</em> Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF-κB Signaling
Supplementary data
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Overcoming Erlotinib Resistance in EGFR Mutation–Positive Non–Small Cell Lung Cancer Cells by Targeting Survivin
Kunio Okamoto; Isamu Okamoto; Erina Hatashita; Kiyoko Kuwata; Haruka Yamaguchi; Aya Kita; Kentaro Yamanaka; Mayumi Ono; Kazuhiko Nakagawa
View articletitled, Overcoming Erlotinib Resistance in <em>EGFR</em> Mutation–Positive Non–Small Cell Lung Cancer Cells by Targeting Survivin
Supplementary data
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Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown
Sara Previdi; Giovanni Abbadessa; Francesca Dalò; Dennis S. France; Massimo Broggini
View articletitled, Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown
Supplementary data
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Epratuzumab–SN-38: A New Antibody–Drug Conjugate for the Therapy of Hematologic Malignancies
Robert M. Sharkey; Serengulam V. Govindan; Thomas M. Cardillo; David M. Goldenberg
View articletitled, Epratuzumab–SN-38: A New Antibody–Drug Conjugate for the Therapy of Hematologic Malignancies
Supplementary data
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Targeting Interleukin-4 Receptor α with Hybrid Peptide for Effective Cancer Therapy
Liying Yang; Tomohisa Horibe; Masayuki Kohno; Mari Haramoto; Koji Ohara; Raj K. Puri; Koji Kawakami
View articletitled, Targeting Interleukin-4 Receptor α with Hybrid Peptide for Effective Cancer Therapy
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Molecular Medicine in Practice

Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Koji Ueno; Hiroshi Hirata; Shahana Majid; Soichiro Yamamura; Varahram Shahryari; Z. Laura Tabatabai; Yuji Hinoda; Rajvir Dahiya
View articletitled, Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Supplementary data
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  • Online ISSN 1538-8514
  • Print ISSN 1535-7163

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