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Volume 10, Issue 9
1 September 2011
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  • Cover Image

    Cover Image

    issue cover
    Nerve growth factor (NGF) immunostaining of human oral squamous cell carcinoma tissues. The image shows high NGF expression in a representative tissue biopsy from an oral cancer patient. Abnormally high levels of NGF are found to play a cardinal role in oral cancer progression, pain, and cachexia through a proinflammatory mechanism. NGF immunoreactions were visualized with diaminobenzidine chromogen (brown) and counterstained with Mayer's hematoxylin. For details, see article by Ye and colleagues on page 1667.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Highlights

Highlights of This Issue
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Review

The Role of Autophagy in Cancer: Therapeutic Implications
Zhineng J. Yang; Cheng E. Chee; Shengbing Huang; Frank A. Sinicrope
View articletitled, The Role of Autophagy in Cancer: Therapeutic Implications
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Therapeutic Discovery

Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models
Matthew Squires; George Ward; Gordan Saxty; Valerio Berdini; Anne Cleasby; Peter King; Patrick Angibaud; Tim Perera; Lynsey Fazal; Douglas Ross; Charlotte Griffiths Jones; Andrew Madin; Rajdeep K. Benning; Emma Vickerstaffe; Alistair O'Brien; Martyn Frederickson; Michael Reader; Christopher Hamlett; Michael A. Batey; Sharna Rich; Maria Carr; Darcey Miller; Ruth Feltell; Abarna Thiru; Susanne Bethell; Lindsay A. Devine; Brent L. Graham; Andrew Pike; Jose Cosme; Edward J. Lewis; Eddy Freyne; John Lyons; Julie Irving; Christopher Murray; David R. Newell; Neil T. Thompson
View articletitled, Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models
Supplementary data
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Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells
Megan Chircop; Swetha Perera; Anna Mariana; Hui Lau; Maggie P.C. Ma; Jayne Gilbert; Nigel C. Jones; Christopher P. Gordon; Kelly A. Young; Andrew Morokoff; Jennette Sakoff; Terence J. O'Brien; Adam McCluskey; Phillip J. Robinson
View articletitled, Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells
Supplementary data
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Linear Chain PEGylated Recombinant Bacillus Thiaminolyticus Thiaminase I Enzyme Has Growth Inhibitory Activity against Lymphoid Leukemia Cell Lines
Abigail Daily; Shuqian Liu; Younsoo Bae; Saloni Bhatnagar; Jeffrey A. Moscow
View articletitled, Linear Chain PEGylated Recombinant <em>Bacillus Thiaminolyticus</em> Thiaminase I Enzyme Has Growth Inhibitory Activity against Lymphoid Leukemia Cell Lines
Supplementary data
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Antitumor Actions of Ruthenium(III)-Based Nitric Oxide Scavengers and Nitric Oxide Synthase Inhibitors
Frederick W. Flitney; Rebecca J. Pritchard; Gordon D. Kennovin; Stuart K. Bisland; David G. Hirst; Simon P. Fricker
View articletitled, Antitumor Actions of Ruthenium(III)-Based Nitric Oxide Scavengers and Nitric Oxide Synthase Inhibitors
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Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer
Daniel Gioeli; Winfried Wunderlich; Judith Sebolt-Leopold; Stefan Bekiranov; Julia D. Wulfkuhle; Emanuel F. Petricoin, III; Mark Conaway; Michael J. Weber
View articletitled, Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer
Supplementary data
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Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor
Yali Kong; Mira Jung; Kan Wang; Scott Grindrod; Alfredo Velena; Sung A. Lee; Sivanesan Dakshanamurthy; Yonghong Yang; Matthew Miessau; Chaoyi Zheng; Anatoly Dritschilo; Milton L. Brown
View articletitled, Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor
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Long Pentraxin-3 Inhibits FGF8b-Dependent Angiogenesis and Growth of Steroid Hormone–Regulated Tumors
Daria Leali; Patrizia Alessi; Daniela Coltrini; Roberto Ronca; Michela Corsini; Giorgia Nardo; Stefano Indraccolo; Marco Presta
View articletitled, Long Pentraxin-3 Inhibits FGF8b-Dependent Angiogenesis and Growth of Steroid Hormone–Regulated Tumors
Supplementary data
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Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine
Per Lund; Irina Kotova; Valérie Kedinger; Harshal Khanwalkar; Emilie Voltz; William C. Hahn; Hinrich Gronemeyer
View articletitled, Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine
Supplementary data
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Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
Alessandro Natoni; Laura S. Murillo; Anna E. Kliszczak; Mark A. Catherwood; Alessia Montagnoli; Afshin Samali; Michael O'Dwyer; Corrado Santocanale
View articletitled, Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
Supplementary data
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Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines
Palaniyandi Ravanan; Renata Sano; Priti Talwar; Satoshi Ogasawara; Shu-ichi Matsuzawa; Michael Cuddy; Sanjay K. Singh; G.S.R. Subba Rao; Paturu Kondaiah; John C. Reed
View articletitled, Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines
Supplementary data
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Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Frédéric R. Santer; Philipp P.S. Höschele; Su Jung Oh; Holger H.H. Erb; Jan Bouchal; Ilaria T. Cavarretta; Walther Parson; David J. Meyers; Philip A. Cole; Zoran Culig
View articletitled, Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Supplementary data
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Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc
Ju Wang; Xue-ting Liu; Hui Huang; Gang Xiao; Zhi-you Zhou; Yang Chen; Zhi-hong Yu; Shui-lian He; An-an Chen; Ding-ding Wang; Ying He; Zhi-cheng Zhang; An Hong
View articletitled, Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc
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Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia
Yi Ye; Dongmin Dang; Jianan Zhang; Chi T. Viet; David K. Lam; John C. Dolan; Jennifer L. Gibbs; Brian L. Schmidt
View articletitled, Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia
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Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity
Qi Zhao; Yang Feng; Zhongyu Zhu; Dimiter S. Dimitrov
View articletitled, Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity
Supplementary data
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Preclinical Development

Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo
Girija Dasmahapatra; Dmitry Lembersky; Minkyeong P. Son; Elisa Attkisson; Paul Dent; Richard I. Fisher; Jonathan W. Friedberg; Steven Grant
View articletitled, Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells <em>In Vitro</em> and <em>In Vivo</em>
Supplementary data
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Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth
Melissa L. Fishel; Yanlin Jiang; N.V. Rajeshkumar; Glenda Scandura; Anthony L. Sinn; Ying He; Changyu Shen; David R. Jones; Karen E. Pollok; Mircea Ivan; Anirban Maitra; Mark R. Kelley
View articletitled, Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth
Supplementary data
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Spectrum of Cellular Responses to Pyriplatin, a Monofunctional Cationic Antineoplastic Platinum(II) Compound, in Human Cancer Cells
Katherine S. Lovejoy; Maria Serova; Ivan Bieche; Shahin Emami; Maurizio D'Incalci; Massimo Broggini; Eugenio Erba; Christian Gespach; Esteban Cvitkovic; Sandrine Faivre; Eric Raymond; Stephen J. Lippard
View articletitled, Spectrum of Cellular Responses to Pyriplatin, a Monofunctional Cationic Antineoplastic Platinum(II) Compound, in Human Cancer Cells
Supplementary data
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Liposomal Delivery of MicroRNA-7–Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells
Kammei Rai; Nagio Takigawa; Sachio Ito; Hiromi Kashihara; Eiki Ichihara; Tatsuji Yasuda; Kenji Shimizu; Mitsune Tanimoto; Katsuyuki Kiura
View articletitled, Liposomal Delivery of MicroRNA-7–Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells
Supplementary data
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In Vitro and In Vivo Responses of Advanced Prostate Tumors to PSMA ADC, an Auristatin-Conjugated Antibody to Prostate-Specific Membrane Antigen
Xinning Wang; Dangshe Ma; William C. Olson; Warren D.W. Heston
View articletitled, <em>In Vitro</em> and <em>In Vivo</em> Responses of Advanced Prostate Tumors to PSMA ADC, an Auristatin-Conjugated Antibody to Prostate-Specific Membrane Antigen
Supplementary data
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Discovery of a Small Molecule Targeting IRA2 Deletion in Budding Yeast and Neurofibromin Loss in Malignant Peripheral Nerve Sheath Tumor Cells
Matthew Wood; Melissa Rawe; Gunnar Johansson; Shu Pang; Ryan S. Soderquist; Ami V. Patel; Sandra Nelson; William Seibel; Nancy Ratner; Yolanda Sanchez
View articletitled, Discovery of a Small Molecule Targeting <em>IRA2</em> Deletion in Budding Yeast and Neurofibromin Loss in Malignant Peripheral Nerve Sheath Tumor Cells
Supplementary data
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Molecular Medicine in Practice

Exon 11 Skipping of E-Cadherin RNA Downregulates Its Expression in Head and Neck Cancer Cells
Sanjai Sharma; Wei Liao; Xiaofeng Zhou; David T.W. Wong; Alan Lichtenstein
View articletitled, Exon 11 Skipping of E-Cadherin RNA Downregulates Its Expression in Head and Neck Cancer Cells
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