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1 September 2011
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Cover Image
Cover Image
Nerve growth factor (NGF) immunostaining of human oral squamous cell carcinoma tissues. The image shows high NGF expression in a representative tissue biopsy from an oral cancer patient. Abnormally high levels of NGF are found to play a cardinal role in oral cancer progression, pain, and cachexia through a proinflammatory mechanism. NGF immunoreactions were visualized with diaminobenzidine chromogen (brown) and counterstained with Mayer's hematoxylin. For details, see article by Ye and colleagues on page 1667. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Therapeutic Discovery
Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models
Matthew Squires; George Ward; Gordan Saxty; Valerio Berdini; Anne Cleasby; Peter King; Patrick Angibaud; Tim Perera; Lynsey Fazal; Douglas Ross; Charlotte Griffiths Jones; Andrew Madin; Rajdeep K. Benning; Emma Vickerstaffe; Alistair O'Brien; Martyn Frederickson; Michael Reader; Christopher Hamlett; Michael A. Batey; Sharna Rich; Maria Carr; Darcey Miller; Ruth Feltell; Abarna Thiru; Susanne Bethell; Lindsay A. Devine; Brent L. Graham; Andrew Pike; Jose Cosme; Edward J. Lewis; Eddy Freyne; John Lyons; Julie Irving; Christopher Murray; David R. Newell; Neil T. Thompson
Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells
Megan Chircop; Swetha Perera; Anna Mariana; Hui Lau; Maggie P.C. Ma; Jayne Gilbert; Nigel C. Jones; Christopher P. Gordon; Kelly A. Young; Andrew Morokoff; Jennette Sakoff; Terence J. O'Brien; Adam McCluskey; Phillip J. Robinson
Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines
Palaniyandi Ravanan; Renata Sano; Priti Talwar; Satoshi Ogasawara; Shu-ichi Matsuzawa; Michael Cuddy; Sanjay K. Singh; G.S.R. Subba Rao; Paturu Kondaiah; John C. Reed
Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Frédéric R. Santer; Philipp P.S. Höschele; Su Jung Oh; Holger H.H. Erb; Jan Bouchal; Ilaria T. Cavarretta; Walther Parson; David J. Meyers; Philip A. Cole; Zoran Culig
Preclinical Development
Spectrum of Cellular Responses to Pyriplatin, a Monofunctional Cationic Antineoplastic Platinum(II) Compound, in Human Cancer Cells
Katherine S. Lovejoy; Maria Serova; Ivan Bieche; Shahin Emami; Maurizio D'Incalci; Massimo Broggini; Eugenio Erba; Christian Gespach; Esteban Cvitkovic; Sandrine Faivre; Eric Raymond; Stephen J. Lippard
Molecular Medicine in Practice
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