Issues

VEGF and placental growth factor promote angiogenesis in developing tumors. A novel fusion protein sFLT01 neutralized VEGF and PlGF, and inhibited tumor growth and blood vessel development in preclinical tumor models. Using immunofluorescence, it was found that sFLT01 localized to vascular areas in human A673 Ewing's sarcoma tumors. VEGFR2 protein was also detected throughout the tumor microenvironment. For details, see article by Bagley and colleagues on page 404.