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1 November 2011
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Cover Image
Cover Image
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Met kinase homology model with its inhibitor, SU11271, docked in the ATP binding site. The cover image was selected from an article previously published in Molecular Cancer Therapeutics, which was chosen in celebration of the 10th anniversary of the journal. For details, see the commentary by Wang and colleagues on page 2022.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
From the Editor-in-Chief
The Best of MCT–10 Years
Review
Therapeutic Discovery
Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput Screening
Agnieszka B. Bialkowska; Melissa Crisp; Thomas Bannister; Yuanjun He; Sarwat Chowdhury; Stephan Schürer; Peter Chase; Timothy Spicer; Franck Madoux; Chenlu Tian; Peter Hodder; Daniel Zaharevitz; Vincent W. Yang
Preclinical Development
The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-Amplified Neuroblastoma In Vivo
Amir Faisal; Lynsey Vaughan; Vassilios Bavetsias; Chongbo Sun; Butrus Atrash; Sian Avery; Yann Jamin; Simon P. Robinson; Paul Workman; Julian Blagg; Florence I. Raynaud; Suzanne A. Eccles; Louis Chesler; Spiros Linardopoulos
Activation of the Insulin-like Growth Factor-1 Receptor Induces Resistance to Epidermal Growth Factor Receptor Antagonism in Head and Neck Squamous Carcinoma Cells
Mark J. Jameson; Andrew D. Beckler; Linnea E. Taniguchi; Amir Allak; Lisa B. VanWagner; Nora G. Lee; William C. Thomsen; Matthew A. Hubbard; Christopher Y. Thomas
Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment
Jayme B. Stokes; Sara J. Adair; Jill K. Slack-Davis; Dustin M. Walters; Robert W. Tilghman; E. Dan Hershey; Bryce Lowrey; Keena S. Thomas; Amy H. Bouton; Rosa F. Hwang; Edward B. Stelow; J. Thomas Parsons; Todd W. Bauer
Targeting FGFR/PDGFR/VEGFR Impairs Tumor Growth, Angiogenesis, and Metastasis by Effects on Tumor Cells, Endothelial Cells, and Pericytes in Pancreatic Cancer
Johannes Taeger; Christian Moser; Claus Hellerbrand; Maria E. Mycielska; Gabriel Glockzin; Hans J. Schlitt; Edward K. Geissler; Oliver Stoeltzing; Sven A. Lang
Molecular Medicine in Practice
Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization
Timothy Meier; Mark Uhlik; Sudhakar Chintharlapalli; Michele Dowless; Robert Van Horn; Julie Stewart; Wayne Blosser; James Cook; Debra Young; Xiang Ye; Glenn Evans; Kelly Credille; Darryl Ballard; Lysiane Huber; Andrew Capen; Marcio Chedid; Robert Ilaria, Jr; Michele C. Smith; Louis Stancato
Antitumoral Effects of Calcitriol in Basal Cell Carcinomas Involve Inhibition of Hedgehog Signaling and Induction of Vitamin D Receptor Signaling and Differentiation
Anja Uhmann; Hannah Niemann; Bérénice Lammering; Cornelia Henkel; Ina Heß; Frauke Nitzki; Anne Fritsch; Nicole Prüfer; Albert Rosenberger; Christian Dullin; Anke Schraepler; Julia Reifenberger; Stefan Schweyer; Torsten Pietsch; Frank Strutz; Walter Schulz-Schaeffer; Heidi Hahn
PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Jing Yuan; Pramod P. Mehta; Min-Jean Yin; Shaoxian Sun; Aihua Zou; Jeffrey Chen; Kristina Rafidi; Zheng Feng; Jeffrey Nickel; Jon Engebretsen; Jill Hallin; Alessandra Blasina; Eric Zhang; Leslie Nguyen; Minghao Sun; Peter K. Vogt; Aileen McHarg; Hengmiao Cheng; James G. Christensen; Julie L.C. Kan; Shubha Bagrodia
A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models
Genshi Zhao; Wei-ying Li; Daohong Chen; James R. Henry; Hong-Yu Li; Zhaogen Chen; Mohammad Zia-Ebrahimi; Laura Bloem; Yan Zhai; Karen Huss; Sheng-bin Peng; Denis J. McCann
Correction
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