Issues

RLIP76 is a glutathione-conjugate transporter that is overexpressed in many cancers and involved in oxidative stress response. Cellular oxidative-stress and clathrin-dependent endocytosis (CDE) are involved in the transcriptional reprogramming that regulates carcinogenesis. Targeted depletion of RLIP76 causes sustained regression of human xenografts of various cancers without any overt toxicity in mice. In this regard, Singhal and colleagues studies revealed that CDE of EGF-rhodamine was markedly deficient in RLIP76 knockout MEF, whereas phorbol ester and benzo[a]pyrene were ineffective in causing neoplasia in RLIP76 knockout mice. For details, please see article by Singhal and colleagues on page 16.