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1 January 2011
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RLIP76 is a glutathione-conjugate transporter that is overexpressed in many cancers and involved in oxidative stress response. Cellular oxidative-stress and clathrin-dependent endocytosis (CDE) are involved in the transcriptional reprogramming that regulates carcinogenesis. Targeted depletion of RLIP76 causes sustained regression of human xenografts of various cancers without any overt toxicity in mice. In this regard, Singhal and colleagues studies revealed that CDE of EGF-rhodamine was markedly deficient in RLIP76 knockout MEF, whereas phorbol ester and benzo[a]pyrene were ineffective in causing neoplasia in RLIP76 knockout mice. For details, please see article by Singhal and colleagues on page 16.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Spotlight on Clinical Response
Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer
Maria C. Villarroel; N.V. Rajeshkumar; Ignacio Garrido-Laguna; Ana De Jesus-Acosta; Siân Jones; Anirban Maitra; Ralph H. Hruban; James R. Eshleman; Alison Klein; Daniel Laheru; Ross Donehower; Manuel Hidalgo
Review
Therapeutic Discovery
Glutathione-Conjugate Transport by RLIP76 Is Required for Clathrin-Dependent Endocytosis and Chemical Carcinogenesis
Sharad S. Singhal; Dilki Wickramarachchi; Sushma Yadav; Jyotsana Singhal; Kathryn Leake; Rit Vatsyayan; Pankaj Chaudhary; Poorna Lelsani; Sumihiro Suzuki; Shaohua Yang; Yogesh C. Awasthi; Sanjay Awasthi
Preclinical Development
Drug Efflux by Breast Cancer Resistance Protein Is a Mechanism of Resistance to the Benzimidazole Insulin-Like Growth Factor Receptor/Insulin Receptor Inhibitor, BMS-536924
Xiaonan Hou; Fei Huang; Joan M. Carboni; Karen Flatten; Yan W. Asmann; Cynthia Ten Eyck; Takeo Nakanishi; Jennifer D. Tibodeau; Douglas D. Ross; Marco M. Gottardis; Charles Erlichman; Scott H. Kaufmann; Paul Haluska
MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells In vitro and In vivo by Downregulating Growth and DNA Repair Signals
Francesco Marampon; Giovanni Luca Gravina; Agnese Di Rocco; Pierluigi Bonfili; Mario Di Staso; Caterina Fardella; Lorella Polidoro; Carmela Ciccarelli; Claudio Festuccia; Vladimir M. Popov; Richard G. Pestell; Vincenzo Tombolini; Bianca Maria Zani
Sorafenib Inhibits the Hepatocyte Growth Factor–Mediated Epithelial Mesenchymal Transition in Hepatocellular Carcinoma
Tomoyuki Nagai; Tokuzo Arao; Kazuyuki Furuta; Kazuko Sakai; Kanae Kudo; Hiroyasu Kaneda; Daisuke Tamura; Keiichi Aomatsu; Hideharu Kimura; Yoshihiko Fujita; Kazuko Matsumoto; Nagahiro Saijo; Masatoshi Kudo; Kazuto Nishio
Lysophosphatidylcholine Pretreatment Reduces VLA-4 and P-Selectin–Mediated B16.F10 Melanoma Cell Adhesion In vitro and Inhibits Metastasis-Like Lung Invasion In vivo
Peter Jantscheff; Martin Schlesinger; Juliane Fritzsche; Lenka A. Taylor; Ralph Graeser; Gregor Kirfel; Dieter O. Fürst; Ulrich Massing; Gerd Bendas
Molecular Medicine in Practice
Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients with Advanced Malignancies: A Phase I Clinical Trial
Apostolia-Maria Tsimberidou; Chris H.M. Takimoto; Stacy Moulder; Cynthia Uehara; Monica Mita; Alain Mita; Patrick Urban; Eugene Tan; Yanfeng Wang; David Vining; Razelle Kurzrock
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