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1 March 2023
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Destabilization of TRIB2 protein by Daclatasvir. Read the full article on page 381.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Small Molecule Therapeutics
Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma
Kohei Takano; Yoichi Munehira; Mana Hatanaka; Ryo Murakami; Yoshihiro Shibata; Takeshi Shida; Kosuke Takeuchi; Sho Takechi; Toshiki Tabata; Takashi Shimada; Shuhei Kishikawa; Yumi Matsui; Osamu Ubukata; Takahiko Seki; Yasuyuki Kaneta
Venadaparib Is a Novel and Selective PARP Inhibitor with Improved Physicochemical Properties, Efficacy, and Safety
Myongjae Lee; In-Gyu Je; Jeong Eun Kim; Yeongran Yoo; Jong-Ha Lim; Eunhye Jang; Yoonsuk Lee; Dong Keun Song; An-Na Moon; Jeong-Ah Kim; Jinah Jeong; Joon-Tae Park; Jung Woo Lee; Ji-Hoon Yang; Chang-Hee Hong; Sun-Young Park; Young-Whan Park; Nam Seok Baek; Sungsook Lee; Kyoung Soo Ha; SungKu Choi; Won Sik Lee
Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma
Giulia Anichini; Chiara Raggi; Mirella Pastore; Laura Carrassa; Luisa Maresca; Enrica Crivaro; Tiziano Lottini; Lea Duwe; Jesper B. Andersen; Lorenzo Tofani; Luca Di Tommaso; Jesus M. Banales; Annarosa Arcangeli; Fabio Marra; Barbara Stecca
Large Molecule Therapeutics
A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes
Andres E. Perez Bay; Devon Faulkner; John O. DaSilva; Tara M. Young; Katie Yang; Jason T. Giurleo; Dangshe Ma; Frank J. Delfino; William C. Olson; Gavin Thurston; Christopher Daly; Julian Andreev
Targeting Drug Resistance
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
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