Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain

Mol Cancer Ther (2007) 6 (9): 2429–2440.
This article has been cited by the following articles in journals that are participating in CrossRef Cited-by Linking.
Multi-spectroscopic and in silico investigation of gambogic acid–calf thymus DNA interactions
  • Boddapati Kalyani Bhardwaj
  • Arsha James
  • Jiya Tomy
  • Shalini K.B
  • Padmanaban S. Suresh
Journal of Biomolecular Structure and Dynamics 1.
Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma
  • Imani Bijou
  • Yang Liu
  • Dong Lu
  • Jianwei Chen
  • Shelby Sloan
  • Lapo Alinari
  • David M. Lonard
  • Bert W. O’Malley
  • Michael Wang
  • Jin Wang
  • Francesco Bertolini
PLOS ONE (2024) 19 (4): e0289902.
Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation
  • Mahmoud Youns
  • Momen Askoura
  • Hisham A Abbas
  • Gouda H Attia
  • Ahdab N Khayyat
  • Reham M Goda
  • Ahmad J Almalki
  • El-Sayed Khafagy
  • Wael AH Hegazy
OncoTargets and Therapy (2021) Volume 14: 3849.
Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC–MS
  • Minxia Fan
  • Guilin Chen
  • Baoqing Sun
  • Jianlin Wu
  • Na Li
  • Satyajit D. Sarker
  • Lutfun Nahar
  • Mingquan Guo
Phytochemistry Reviews (2020) 19 (5): 1231.
Design and synthesis of 3,5-substituted 1,2,4-oxadiazoles as catalytic inhibitors of human DNA topoisomerase IIα
  • Kaja Bergant Loboda
  • Katja Valjavec
  • Martina Štampar
  • Gerhard Wolber
  • Bojana Žegura
  • Metka Filipič
  • Marija Sollner Dolenc
  • Andrej Perdih
Bioorganic Chemistry (2020) 99: 103828.
Synthesis of New Chiral Derivatives of Xanthones with Enantioselective Effect on Tumor Cell Growth and DNA Crosslinking
  • Maria L. Carraro
  • Sandra Marques
  • Ana Sofia Silva
  • Bruno Freitas
  • Patrícia M. A. Silva
  • Joel Pedrosa
  • Paolo De Marco
  • Hassan Bousbaa
  • Carla Fernandes
  • Maria Elizabeth Tiritan
  • Artur M. S. Silva
  • Madalena M. M. Pinto
ChemistrySelect (2020) 5 (33): 10285.
Antiproliferative and Enzyme Docking Analysis of Engleromycin from Engleromyces goetzei
  • Yongli Zhang
  • Guilin Chen
  • Hong Ma
  • Mingquan Guo
Molecules (2019) 24 (1): 166.
Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands
  • Ívina P. de Souza
  • Bárbara de P. Machado
  • Alexandre B. de Carvalho
  • Ildefonso Binatti
  • Klaus Krambrock
  • Zara Molphy
  • Andrew Kellett
  • Elene C. Pereira-Maia
  • Priscila P. Silva-Caldeira
Journal of Molecular Structure (2019) 1178: 18.
Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
  • Min Ji Seo
  • Dong Min Lee
  • In Young Kim
  • Dongjoo Lee
  • Min-Koo Choi
  • Joo-Youn Lee
  • Seok Soon Park
  • Seong-Yun Jeong
  • Eun Kyung Choi
  • Kyeong Sook Choi
Cell Death & Disease (2019) 10 (3)
New thiobarbituric acid scaffold-based small molecules: Synthesis, cytotoxicity, 2D-QSAR, pharmacophore modelling and in-silico ADME screening
  • Heba S.A. El-Zahabi
  • Maha M.A. Khalifa
  • Yomna M.H. Gado
  • Amel M. Farrag
  • Mahmoud M. Elaasser
  • Nesreen A. Safwat
  • Reham R. AbdelRaouf
  • Reem K. Arafa
European Journal of Pharmaceutical Sciences (2019) 130: 124.
Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes
  • Oraphin Chantarasriwong
  • Tanis J. Dorwart
  • Theodore Habarth Morales
  • Stephanie F. Maggio
  • Aspen L. Settle
  • Andrew T. Milcarek
  • Mary L. Alpaugh
  • Maria A. Theodoraki
  • Emmanuel A. Theodorakis
Bioorganic Chemistry (2019) 93: 103303.
The growth inhibitory effect of gambogic acid on pancreatic cancer cells
  • Mаhmoud Youns
  • Abeer ElKhoely
  • Rehab Kamel
Naunyn-Schmiedeberg's Archives of Pharmacology (2018) 391 (5): 551.
Rapid re-evaluation of bioactive saponins from Paris polyphylla using affinity ultrafiltration-LC/MS with multiple drug targets
  • Guilin Chen
  • Mingquan Guo
International Journal of Mass Spectrometry (2018) 434: 87.
Co(III) complexes based on α-N-heterocyclic thiosemicarbazone ligands: DNA binding, DNA cleavage, and topoisomerase I/II inhibitory activity studies
  • JunGang Deng
  • Tao Li
  • Gaoxing Su
  • Qi-Pin Qin
  • Yani Liu
  • Yi Gou
Journal of Molecular Structure (2018) 1167: 33.
Role of gambogic acid and NaI131 in A549/DDP cells
  • Jing Huang
  • Xiaoli Zhu
  • Huan Wang
  • Shuhua Han
  • Lu Liu
  • Yan Xie
  • Daozhen Chen
  • Qiang Zhang
  • Li Zhang
  • Yue Hu
Oncology Letters (2017) 13 (1): 37.
Exploration of acute genotoxic effects and antigenotoxic potential of gambogic acid using Allium cepa assay
  • Abhishek Shetty
  • Thejaswini Venkatesh
  • Padmanaban S. Suresh
  • Rie Tsutsumi
Plant Physiology and Biochemistry (2017) 118: 643.
Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products
  • Caiping Tian
  • Rui Sun
  • Keke Liu
  • Ling Fu
  • Xiaoyu Liu
  • Wanqi Zhou
  • Yong Yang
  • Jing Yang
Cell Chemical Biology (2017) 24 (11): 1416.
Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα
  • Elirosa Minniti
  • Jo Ann W. Byl
  • Laura Riccardi
  • Claudia Sissi
  • Michela Rosini
  • Marco De Vivo
  • Anna Minarini
  • Neil Osheroff
Bioorganic & Medicinal Chemistry Letters (2017) 27 (20): 4687.
Antitumor effect of forbesione isolated from Garcinia hanburyi on cholangiocarcinoma in vitro and in vivo
  • Parichart Boueroy
  • Chariya Hahnvajanawong
  • Thidarut Boonmars
  • Sunitta Saensa-Ard
  • Natthinee Anantachoke
  • Kulthida Vaeteewoottacharn
  • Vichai Reutrakul
Oncology Letters (2016) 12 (6): 4685.
Caged xanthones: Potent inhibitors of global predominant MRSA USA300
  • Pongkorn Chaiyakunvat
  • Natthinee Anantachoke
  • Vichai Reutrakul
  • Chutima Jiarpinitnun
Bioorganic & Medicinal Chemistry Letters (2016) 26 (13): 2980.
UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3β/β-catenin pathway in hepatocellular carcinoma cells
  • Lili Wu
  • Haifei Guo
  • Hongyu Sun
  • Wu Zhang
  • Changzheng Sun
  • Jianhua Wang
Anti-Cancer Drugs (2016) 27 (10): 988.
Gambogic acid induces apoptosis and sensitizes TRAIL-mediated apoptosis through downregulation of cFLIPL in renal carcinoma Caki cells
  • JI HOON JANG
  • JOO-YOUNG KIM
  • EON-GI SUNG
  • EUN-AE KIM
  • TAE-JIN LEE
International Journal of Oncology (2016) 48 (1): 376.
Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90
  • Kyu-Yeon Jun
  • Youngjoo Kwon
Biomolecules & Therapeutics (2016) 24 (5): 453.
Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics
  • Yiqing Zhou
  • Weichao Li
  • Xixi Zhang
  • Haibing Zhang
  • Youli Xiao
Chemical Communications (2016) 52 (97): 14035.
Recent Research on Bioactive Xanthones from Natural Medicine: Garcinia hanburyi
  • Buyun Jia
  • Shanshan Li
  • Xuerui Hu
  • Guangyu Zhu
  • Weidong Chen
AAPS PharmSciTech (2015) 16 (4): 742.
Synthesis and Bioevaluation of Novel Oxa-Caged Garcinia Xanthones as Anti-Tumour Agents
  • Guangqiang Miao
  • Junhai Ma
  • Kan Yang
  • Zhipeng Huang
  • Qinlan Gu
  • Yanjie Wang
  • Qinglong Guo
  • Qidong You
  • Jinxin Wang
Australian Journal of Chemistry (2015) 68 (6): 872.
Discovery of Mono‐ and Disubstituted 1H‐Pyrazolo[3,4]pyrimidines and 9H‐Purines as Catalytic Inhibitors of Human DNA Topoisomerase IIα
  • Barbara Pogorelčnik
  • Matjaž Brvar
  • Bojana Žegura
  • Metka Filipič
  • Tom Solmajer
  • Andrej Perdih
ChemMedChem (2015) 10 (2): 345.
Michael acceptor in gambogic acid—Its role and application for potent antitumor agents
  • Jing Wang
  • Wang Shen
  • Zhiliang Yuan
  • Lihong Lan
  • Jiwen Xu
  • Chuan Wang
  • Guangming Ma
  • Weihua Shi
  • Lixia Han
  • Zhixiang Zhang
  • Lijuan Hou
  • Liang Shen
  • Zhigan Jiang
  • Haiying He
  • Wei Xiao
  • Zhenzhong Wang
  • Qingming Guo
  • Jian Li
  • Shuhui Chen
Bioorganic & Medicinal Chemistry Letters (2015) 25 (14): 2844.
Involvement of RECK in gambogic acid induced anti‐invasive effect in A549 human lung carcinoma cells
  • Qi Qi
  • Na Lu
  • Chenglin Li
  • Jie Zhao
  • Wei Liu
  • Qidong You
  • Qinglong Guo
Molecular Carcinogenesis (2015) 54 (S1)
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site
  • Barbara Pogorelčnik
  • Matej Janežič
  • Izidor Sosič
  • Stanislav Gobec
  • Tom Solmajer
  • Andrej Perdih
Bioorganic & Medicinal Chemistry (2015) 23 (15): 4218.
Dual-functional bio-derived nanoparticulates for apoptotic antitumor therapy
  • Yang Ding
  • Yazhe Wang
  • Yaw Opoku-Damoah
  • Cheng Wang
  • Lingjia Shen
  • Lifang Yin
  • Jianping Zhou
Biomaterials (2015) 72: 90.
Salicylate, a Catalytic Inhibitor of Topoisomerase II, Inhibits DNA Cleavage and Is Selective for the α Isoform
  • Jason T. Bau
  • Zhili Kang
  • Caroline A. Austin
  • Ebba U. Kurz
Molecular Pharmacology (2014) 85 (2): 198.
Advances in Copper Complexes as Anticancer Agents
  • Carlo Santini
  • Maura Pellei
  • Valentina Gandin
  • Marina Porchia
  • Francesco Tisato
  • Cristina Marzano
Chemical Reviews (2014) 114 (1): 815.
Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase
  • Dongzhu Duan
  • Baoxin Zhang
  • Juan Yao
  • Yaping Liu
  • Jinyu Sun
  • Chunpo Ge
  • Shoujiao Peng
  • Jianguo Fang
Free Radical Biology and Medicine (2014) 69: 15.
Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIα
  • Barbara Pogorelčnik
  • Matjaž Brvar
  • Irena Zajc
  • Metka Filipič
  • Tom Solmajer
  • Andrej Perdih
Bioorganic & Medicinal Chemistry Letters (2014) 24 (24): 5762.
Synergistic effects of isomorellin and forbesione with doxorubicin on apoptosis induction in human cholangiocarcinoma cell lines
  • Chariya Hahnvajanawong
  • Wareeporn Wattanawongdon
  • Chariya Chomvarin
  • Natthinee Anantachoke
  • Sakawrat Kanthawong
  • Banchob Sripa
  • Vichai Reutrakul
Cancer Cell International (2014) 14 (1): 68.
An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors
  • Yihebali CHI
  • Xiao-kai ZHAN
  • Hao YU
  • Guang-ru XIE
  • Zhen-zhong WANG
  • Wei XIAO
  • Yong-gang WANG
  • Fu-xing XIONG
  • Jun-feng HU
  • Lin YANG
  • Cheng-xu CUI
  • Jin-wan WANG
Chinese Medical Journal (2013) 126 (9): 1642.
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
  • Jenny Felth
  • Karolina Lesiak-Mieczkowska
  • Padraig D’Arcy
  • Caroline Haglund
  • Joachim Gullbo
  • Rolf Larsson
  • Stig Linder
  • Lars Bohlin
  • Mårten Fryknäs
  • Linda Rickardson
Investigational New Drugs (2013) 31 (3): 587.
Gambogic Acid as a Non‐Competitive Inhibitor of ATP‐Binding Cassette Transporter B1 Reverses the Multidrug Resistance of Human Epithelial Cancers by Promoting ATP‐Binding Cassette Transporter B1 Protein Degradation
  • Xu Wang
  • Rongxin Deng
  • Yan Lu
  • Qin Xu
  • Ming Yan
  • Dongxia Ye
  • Wantao Chen
Basic & Clinical Pharmacology & Toxicology (2013) 112 (1): 25.
Garcinia Xanthones as Orally Active Antitumor Agents
  • Xiaojin Zhang
  • Xiang Li
  • Haopeng Sun
  • Xiaojian Wang
  • Li Zhao
  • Yuan Gao
  • Xiaorong Liu
  • Shenglie Zhang
  • Yanyan Wang
  • Yingrui Yang
  • Su Zeng
  • Qinglong Guo
  • Qidong You
Journal of Medicinal Chemistry (2013) 56 (1): 276.
Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy
  • Shengpeng Wang
  • Xu Wu
  • Miao Tan
  • Jian Gong
  • Wen Tan
  • Baolin Bian
  • Meiwan Chen
  • Yitao Wang
Journal of Ethnopharmacology (2012) 140 (1): 33.
Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
  • Chenglin Li
  • Qi Qi
  • Na Lu
  • Qinsheng Dai
  • Fanni Li
  • Xiaotang Wang
  • Qidong You
  • Qinglong Guo
Biochemistry and Cell Biology (2012) 90 (6): 718.
Studies on gambogic acid (IV): Exploring structure–activity relationship with IκB kinase-beta (IKKβ)
  • Haopeng Sun
  • Feihong Chen
  • Xiaojian Wang
  • Zongliang Liu
  • Qian Yang
  • Xiaojin Zhang
  • Jia Zhu
  • Lei Qiang
  • Qinglong Guo
  • Qidong You
European Journal of Medicinal Chemistry (2012) 51: 110.
Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy
  • Christian Bailly
Chemical Reviews (2012) 112 (7): 3611.
Subcellular Localization and Activity of Gambogic Acid
  • Gianni Guizzunti
  • Ayse Batova
  • Oraphin Chantarasriwong
  • Marianna Dakanali
  • Emmanuel A. Theodorakis
ChemBioChem (2012) 13 (8): 1191.
Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II
  • Xia Xue
  • Xian-Jun Qu
  • Zu-Hua Gao
  • Cui-Cui Sun
  • Hui-Ping Liu
  • Cui-Rong Zhao
  • Yan-Na Cheng
  • Hong-Xiang Lou
Investigational New Drugs (2012) 30 (1): 212.
Prenylated caged xanthones: Chemistry and biology
  • Natthinee Anantachoke
  • Patoomratana Tuchinda
  • Chutima Kuhakarn
  • Manat Pohmakotr
  • Vichai Reutrakul
Pharmaceutical Biology (2012) 50 (1): 78.
Involvement of p53 and Nuclear Factor-kappaB Signaling Pathway for the Induction of G1-Phase Cell Cycle Arrest of Cholangiocarcinoma Cell Lines by Isomorellin
  • Chariya Hahnvajanawong
  • Supaluk Ketnimit
  • Kovit Pattanapanyasat
  • Natthinee Anantachoke
  • Banchob Sripa
  • Khosit Pinmai
  • Wunchana Seubwai
  • Vichai Reutrakul
Biological and Pharmaceutical Bulletin (2012) 35 (11): 1914.
Anticancer Drugs from Traditional Toxic Chinese Medicines
  • Shuli Man
  • Wenyuan Gao
  • Changlong Wei
  • Changxiao Liu
Phytotherapy Research (2012) 26 (10): 1449.
N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase
  • Ashish T. Baviskar
  • Chetna Madaan
  • Ranjan Preet
  • Purusottam Mohapatra
  • Vaibhav Jain
  • Amit Agarwal
  • Sankar K. Guchhait
  • Chanakya N. Kundu
  • Uttam C. Banerjee
  • Prasad V. Bharatam
Journal of Medicinal Chemistry (2011) 54 (14): 5013.
  • Online ISSN 1538-8514
  • Print ISSN 1535-7163

AACR Journals

 

 

  • Copyright © 2023 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept