Diet can play a vital role in cancer prevention. Studies have shown that a diet high in fruits and vegetables is associated with a reduced risk of cancer. Apigenin is a non-toxic and non-mutagenic natural flavonoid. Our previous studies demonstrated the effects of apigenin on angiogenesis in CAM model is by two distintic parallel PI3K/AKT and jak/STAT pathways. Vascular endothelial growth factor (VEGF) is one of the most important of all known inducers of angiogenesis and in many cancers this protein is over-expressed. Studies confirm Apigenin efficient on reduction VEGF expression. In this study, as first time, effect of Apigenin is evaluated by oral administration on angiogenesis decreasing and VEGF expression levels were measured in creatures. After infection of mice's ovarian by A2780 cancer cell line, Apigenin (75/mg/kg/day) were fed once a day for 30 days to the animals and angiogenesis measured in vivo. Histological methods were used for counting blood vessels, ELISA analysis was used to measurement of VEGF protein in infected tissues. to confirm the effect of oral administration of Apigenin on VEGF expression, A2780 cells were infected by VEGF promoter reporter vectors then injected to the mice. Studies have shown that taking these orally, Apigenin reduced VEGF expression and ultimately leads to reduced angiogenesis.

Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C7.

Citation Format: Majid Alipour. Inhibitory effects of flavonoid Apigenin by oral administration on angiogenesis of ovarian cancer through decrease VEGF expression in mouse model. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C7.