Photoimmunotherapy (PIT) is a promising field for cancer treatment that combines the phototoxic and immune stimulating ability of photodynamic therapy (PDT) with the widespread effectiveness of the immune system. We speculated that co-delivery of an immune-stimulant with a photosensitizer (PS) using a nanoparticle (NP) delivery platform will be a useful means to attack metastatic cancer. To probe this, we have initiated the construction of new PIT agents using a multifunctional NP delivery platform. Briefly, we encapsulated a PS within a polymeric NP core made up of poly(D,L-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG). After coating the outside of the polymeric core with gold nanoparticles, we modified the gold surface with CpG-ODN, a single-stranded DNA that is a known immunostimulant. Synthesis, biological activity, and immune stimulatory effects of these constructs will be presented.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr A119.