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Journal Articles
Mol Cancer Res molcanres.MCR-21-0722-E.2021.
Published: 09 May 2022
...), Chk1 inhibitor LY2603218 (20 nM, Selleckchem), Chk2 inhibitor PV1019 (1 M, Calbiochem), PKC inhibitor Gö6983 (30 nM, Selleckchem) or Doxorubicin (1µg/ml, Cayman) were used to treat CLL cells. Lentiviral and shRNA transduction A cDNA encoding full-length hKAP1 was cloned by RT-PCR from normal human...
Includes: Supplementary data
Journal Articles
Mol Cancer Res molcanres.0085.2022.
Published: 13 May 2022
... Cancer. J Biol Chem. 2015; 290:2571725727. 21 23. Shapiro B. et al. Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKC Signaling Axis. J Biol Chem. 2016; 291:2166921681. 24. Shultz, J. et al. The Proto-oncogene...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2022) 20 (4): 583–595.
Published: 01 April 2022
... (POT1) have been reported to orchestrate to displace replication protein A (RPA) from telomeric overhangs, ensuring orderly telomere replication and capping. Our previous studies further demonstrated that DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-dependent hnRNPA1 phosphorylation plays...
Includes: Supplementary data
Journal Articles
Mol Cancer Res molcanres.MCR-20-0692-E.2020.
Published: 04 May 2022
.... The discoveries in UM genetics have led to novel clinical trials with a variety of targeted therapeutics that attempted to inhibit signaling pathways associated with these gene mutations. These trials included inhibitors that targeted MEK, protein kinase C (PKC), Akt and mTOR (41,42). The mitogen-activated...
Includes: Supplementary data
Journal Articles
Mol Cancer Res OF1–OF14.
Published: 20 April 2022
... (DNA-PK) is required for nonhomologous end joining (NHEJ), and its catalytic subunit, DNA-PKcs, is overexpressed in human pancreatic cancers (24). Pharmacologic inhibition by the selective DNA-PK inhibitor M3814 (i.e., peposertib), currently in clinical trials, augments radiation ef cacy (25 27). While...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2022) 20 (4): 661–669.
Published: 01 April 2022
... to 15 months ( 6 ). Uveal melanoma is characterized by canonical mutations in the Gα protein subunits (GNAQ/11), resulting in constitutive activation of pathways including PKC and MAPK ( 7 ). MET is overexpressed in 60% to 86% of cases ( 8, 9 ), and its activation stimulates migration and invasion...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2022) 20 (4): 556–567.
Published: 01 April 2022
... Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness . Cell Death Dis 2019 ; 10 : 649 . 32. Jacob S , Nayak S , Kakar R , Chaudhari UK , Joshi D , Vundinti BR , . A triad of telomerase...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2022) 20 (4): 542–555.
Published: 01 April 2022
... , Pazarentzos E , Juric D , Sheng Q , Pelossof RA , Brook S , . AXL mediates resistance to PI3Kalpha inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas . Cancer Cell 2015 ; 27 : 533 – 46 . 10. Byers LA...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2022) 20 (4): 568–582.
Published: 01 April 2022
... , Lees-Miller SP . A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation . DNA Repair 2010 ; 9 : 1307 – 14 . 12. Furgason JM , Bahassi el M . Targeting DNA repair mechanisms in cancer . Pharmacol Ther 2013 ; 137 : 298 – 308 . 13. Zenke...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2022) 20 (3): 387–399.
Published: 03 March 2022
... ( 35 ). Several signaling pathways including PKC, influx of extracellular Ca2+, Rho family of GTPases and Ras regulate ectodomain cleavage ( 24, 36 ). After cleavage of the ectodomain, the remaining membrane bound C-terminal fragment (CD44-CTF) is also a target of intramembrane proteolysis mediated...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2022) 20 (2): 231–243.
Published: 03 February 2022
... of autophagy and lysosomal acidification ( 30 ). Sequence and structural analyses place SGKs within the AGC serine/threonine kinase superfamily, which includes well-known 14-3-3 docking site kinases, such as PKC and AKT ( 35 ). SGK1 has even been shown to phosphorylate 14-3-3 binding sites ( 36, 37...
Images
Inhibition of DNA-<span class="search-highlight">PKcs</span> activity by omipalisib.  A,  The interaction network...
Published: 01 November 2021
Figure 6. Inhibition of DNA-PKcs activity by omipalisib. A, The interaction network of omipalisib. B and C, The expression of DNA-PKcs, phosphorylated DNA-PKcs (Ser2056), mTOR, phosphorylated mTOR (Ser2448), Akt and phosphorylated Akt (Ser473) were analyzed by Western blotting. D, The direct effect of omipalisib on DNA-PK was examined by using DNA-PK activity assay in vitro. NU7441 was used as positive control. E, Dose–response curve was created to determine the potency of the inhibitor (IC50). ***, P < 0.001 versus control group, n = 3. Figure 6. Inhibition of DNA-PKcs activity by omipalisib. A, The interaction network of omipalisib. B and C, The expression of DNA-PKcs, phosphorylated DNA-PKcs (Ser2056), mTOR, phosphorylated mTOR (Ser2448), Akt and phosphorylated Akt (Ser473) were analyzed by Western blotting. D, The direct effect of omipalisib on DNA-PK was examined by using DNA-PK activity assay in vitro. NU7441 was used as positive control. E, Dose–response curve was created to determine the potency of the inhibitor (IC50). ***, P < 0.001 versus control group, n = 3. More
Journal Articles
Mol Cancer Res (2021) 19 (12): 2026–2035.
Published: 02 December 2021
... Biol   1988 ; 106 : 761 – 71 . 29. Adhikary   G , Chew   YC , Reece   EA , Eckert   RL .  PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents . J Invest Dermatol   2010...
Journal Articles
Mol Cancer Res (2021) 19 (11): 1889–1899.
Published: 01 November 2021
...Figure 6. Inhibition of DNA-PKcs activity by omipalisib. A, The interaction network of omipalisib. B and C, The expression of DNA-PKcs, phosphorylated DNA-PKcs (Ser2056), mTOR, phosphorylated mTOR (Ser2448), Akt and phosphorylated Akt (Ser473) were analyzed by Western blotting. D...
Includes: Supplementary data
Journal Articles
Mol Cancer Res (2021) 19 (11): 1793.
Published: 01 November 2021
... the phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in response to chemo- or radiotherapy, a key step in the initiation of NHEJ to mediate their genotoxic effects. Overall, the authors advance a novel screening strategy to examine the effects of pharmacological interventions on DNA...
Journal Articles
Mol Cancer Res (2021) 19 (10): 1712–1726.
Published: 01 October 2021
... carcinoma . J Transl Med   2017 ; 15 : 176 . 7. Lin   M , Liu   Y , Ding   X , Ke   Q , Shi   J , Ma   Z , et al   E2F1 transactivates IQGAP3 and promotes proliferation of hepatocellular carcinoma cells through IQGAP3-mediated PKC-alpha activation . Am J Cancer Res   2019 ; 9...
Includes: Multimedia, Supplementary data
Journal Articles
Mol Cancer Res (2021) 19 (8): 1296–1307.
Published: 01 August 2021
... downregulation was blocked by an adenosine uptake inhibitor indicating AICAR was responsible for IEGs reprogramming. Using pharmacologic and genetic models we established this mechanism was AMPK-independent. Further investigations using kinase assays, PKD/PKC inhibitors and rescue experiments, demonstrated...
Includes: Supplementary data
Images
Proposed model for the effects of AICAR inducing downregulation of IEGs exp...
Published: 01 August 2021
Figure 7. Proposed model for the effects of AICAR inducing downregulation of IEGs expression in mammalian cells. A, Under normal condition, stimuli (PKC, DAG, PMA, etc.) induce PKD activation (p-PKD(S910)) at the plasma membrane promoting phosphorylation and export of class IIa histone deacetyla... More
Journal Articles
Mol Cancer Res (2021) 19 (5): 921–931.
Published: 01 May 2021
... and tumor growth by phosphorylating the translational regulators p70 S6 kinase (S6K) and eIF4E-binding protein 1 (4E-BP1), mTORC2 modulates cell survival and migration by phosphorylating several AGC family kinases, such as Akt and PKC ( 6, 7 ). Accumulating evidence has shown that MM cells often display...
Includes: Supplementary data
Journal Articles
Series: Author Choice
Mol Cancer Res (2020) 18 (7): 1028–1038.
Published: 02 July 2020
... expression of OPN4 suppressed cells growth and induced apoptosis in lung cancer cells. We have also found that OPN4, a G protein-coupled receptor, interacted with Gα11 and triggered the PKC/BRAF/MEK/ERKs signaling pathway in lung adenocarcinoma cells. Genetic ablation of OPN4 attenuated...
Includes: Supplementary data