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Journal Articles

The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer

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Stephen Safe, Keshav Karki
Journal: Molecular Cancer Research
Mol Cancer Res (2021) 19 (2): 180–191.
https://doi.org/10.1158/1541-7786.MCR-20-0707
Published: 03 February 2021
View articletitled, The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer
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Journal Articles

Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma

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Erik Hedrick, Kumaravel Mohankumar, Alexandra Lacey, Stephen Safe
Journal: Molecular Cancer Research
Mol Cancer Res (2019) 17 (11): 2221–2232.
https://doi.org/10.1158/1541-7786.MCR-19-0408
Published: 01 November 2019
View articletitled, Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma
Open the PDF for Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma in another window
Includes: Supplementary data
Journal Articles

Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors

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Ravi Kasiappan, Indira Jutooru, Kumaravel Mohankumar, Keshav Karki, Alexandra Lacey, Stephen Safe
Journal: Molecular Cancer Research
Mol Cancer Res (2019) 17 (3): 794–805.
https://doi.org/10.1158/1541-7786.MCR-18-1071
Published: 01 March 2019
View articletitled, Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors
Open the PDF for Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors in another window
Includes: Supplementary data
Journal Articles

TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent

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Erik Hedrick, Kumaravel Mohankumar, Stephen Safe
Journal: Molecular Cancer Research
Mol Cancer Res (2018) 16 (12): 1991–2002.
https://doi.org/10.1158/1541-7786.MCR-18-0366
Published: 03 December 2018
View articletitled, TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent
Open the PDF for TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent in another window
Includes: Supplementary data
Journal Articles

The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

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Syng-Ook Lee, Un-Ho Jin, Jeong Han Kang, Sang Bae Kim, Aaron S. Guthrie, Sandeep Sreevalsan, Ju-Seog Lee, Stephen Safe
Journal: Molecular Cancer Research
Mol Cancer Res (2014) 12 (4): 527–538.
https://doi.org/10.1158/1541-7786.MCR-13-0567
Published: 01 April 2014
View articletitled, The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells
Open the PDF for The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells in another window
Includes: Supplementary data
Journal Articles

miR-150 Blocks MLL-AF9–Associated Leukemia through Oncogene Repression

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Marina Bousquet, Guoqing Zhuang, Cong Meng, Wei Ying, Patali S. Cheruku, Andrew T. Shie, Stephanie Wang, Guangtao Ge, Piu Wong, Gang Wang, Stephen Safe, Beiyan Zhou
Journal: Molecular Cancer Research
Mol Cancer Res (2013) 11 (8): 912–922.
https://doi.org/10.1158/1541-7786.MCR-13-0002-T
Published: 01 August 2013
View articletitled, miR-150 Blocks MLL-AF9–Associated Leukemia through Oncogene Repression
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Includes: Supplementary data
Journal Articles

GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway

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Satya S. Pathi, Indira Jutooru, Gayathri Chadalapaka, Sandeep Sreevalsan, S Anand, Gregory RJ Thatcher, Stephen Safe
Journal: Molecular Cancer Research
Mol Cancer Res (2011) 9 (2): 195–202.
https://doi.org/10.1158/1541-7786.MCR-10-0363
Published: 15 February 2011
View articletitled, GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway
Open the PDF for GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway in another window
Journal Articles

Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells

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Gayathri Chadalapaka, Indira Jutooru, Robert Burghardt, Stephen Safe
Journal: Molecular Cancer Research
Mol Cancer Res (2010) 8 (5): 739–750.
https://doi.org/10.1158/1541-7786.MCR-09-0493
Published: 01 May 2010
View articletitled, Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells
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Journal Articles

p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor–Induced Bα (Nur77) in Pancreatic Cancer Cells

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Syng-Ook Lee, Sudhakar Chintharlapalli, Shengxi Liu, Sabitha Papineni, Sung Dae Cho, Kyungsil Yoon, Stephen Safe
Journal: Molecular Cancer Research
Mol Cancer Res (2009) 7 (7): 1169–1178.
https://doi.org/10.1158/1541-7786.MCR-08-0473
Published: 15 July 2009
View articletitled, p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor–Induced Bα (Nur77) in Pancreatic Cancer Cells
Open the PDF for p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor–Induced Bα (Nur77) in Pancreatic Cancer Cells in another window
Includes: Supplementary data