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Andrew E. Aplin
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Journal Articles

Metabolic inhibition induces pyroptosis in uveal melanoma

Scott D. Varney, Dan A. Erkes, Glenn L. Mersky, Manal U. Mustafa, Vivian Chua, Inna Chervoneva, Timothy J. Purwin, Emad Alnemri, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2024)
https://doi.org/10.1158/1541-7786.MCR-24-0508
Published: 13 December 2024
View article titled, Metabolic inhibition induces pyroptosis in uveal melanoma
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Includes: Supplementary data
Journal Articles

SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death

Sheera R. Rosenbaum, Signe Caksa, Casey D. Stefanski, Isabella V. Trachtenberg, Haley P. Wilson, Nicole A. Wilski, Connor A. Ott, Timothy J. Purwin, Jelan I. Haj, Danielle Pomante, Daniel Kotas, Inna Chervoneva, Claudia Capparelli, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2024) 22 (2): 209–220.
https://doi.org/10.1158/1541-7786.MCR-23-0290
Published: 01 February 2024
View article titled, SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death
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Includes: Supplementary data
Journal Articles

Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma

Megane Vernon, Nicole A. Wilski, Daniel Kotas, Weijia Cai, Danielle Pomante, Manoela Tiago, Emad S. Alnemri, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2022) 20 (12): 1811–1821.
https://doi.org/10.1158/1541-7786.MCR-22-0040
Published: 02 December 2022
View article titled, Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma
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Includes: Supplementary data
Journal Articles

Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma

Usman Baqai, Timothy J. Purwin, Nelisa Bechtel, Vivian Chua, Anna Han, Edward J. Hartsough, Jeffim N. Kuznetsoff, J. William Harbour, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2022) 20 (8): 1260–1271.
https://doi.org/10.1158/1541-7786.MCR-21-0657
Published: 05 August 2022
View article titled, Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
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Includes: Supplementary data
Journal Articles

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

Dominic Lapadula, Eduardo Farias, Clinita E. Randolph, Timothy J. Purwin, Dougan McGrath, Thomas H. Charpentier, Lihong Zhang, Shihua Wu, Mizue Terai, Takami Sato, Gregory G. Tall, Naiming Zhou, Philip B. Wedegaertner, Andrew E. Aplin, Julio Aguirre-Ghiso, Jeffrey L. Benovic
Journal: Molecular Cancer Research
Mol Cancer Res (2019) 17 (4): 963–973.
https://doi.org/10.1158/1541-7786.MCR-18-0574
Published: 01 April 2019
View article titled, Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma
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Includes: Supplementary data
Journal Articles

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma

Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L. Benovic, Philip B. Wedegaertner, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2017) 15 (5): 501–506.
https://doi.org/10.1158/1541-7786.MCR-17-0007
Published: 01 May 2017
View article titled, Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma
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Journal Articles

Abstract A40: Targeting TBK1 promotes apoptosis in MEK-inhibitor resistant mutant NRAS melanoma cells

Ha Linh Vu, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2014) 12 (12_Supplement): A40.
https://doi.org/10.1158/1557-3125.RASONC14-A40
Published: 01 December 2014
View article titled, Abstract A40: Targeting TBK1 promotes apoptosis in MEK-inhibitor resistant mutant NRAS melanoma cells
Journal Articles

Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma

Ha Linh Vu, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2014) 12 (10): 1509–1519.
https://doi.org/10.1158/1541-7786.MCR-14-0204
Published: 01 October 2014
View article titled, Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma
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Includes: Supplementary data
Journal Articles

FOXD3 Modulates Migration through Direct Transcriptional Repression of TWIST1 in Melanoma

Michele B. Weiss, Ethan V. Abel, Neda Dadpey, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2014) 12 (9): 1314–1323.
https://doi.org/10.1158/1541-7786.MCR-14-0170
Published: 01 September 2014
View article titled, FOXD3 Modulates Migration through Direct Transcriptional Repression of TWIST1 in Melanoma
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Includes: Supplementary data
Journal Articles

Beneficial Effects of RAF Inhibitor in Mutant BRAF Splice Variant–Expressing Melanoma

Edward J. Hartsough, Kevin J. Basile, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2014) 12 (5): 795–802.
https://doi.org/10.1158/1541-7786.MCR-13-0581
Published: 01 May 2014
View article titled, Beneficial Effects of RAF Inhibitor in Mutant BRAF Splice Variant–Expressing Melanoma
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Includes: Supplementary data
Journal Articles

FOXD3 Regulates Migration Properties and Rnd3 Expression in Melanoma Cells

Pragati Katiyar, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2011) 9 (5): 545–552.
https://doi.org/10.1158/1541-7786.MCR-10-0454
Published: 15 May 2011
View article titled, FOXD3 Regulates Migration Properties and Rnd3 Expression in Melanoma Cells
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Journal Articles

Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis

Karen Boisvert-Adamo, Whitney Longmate, Ethan V. Abel, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2009) 7 (4): 549–556.
https://doi.org/10.1158/1541-7786.MCR-08-0358
Published: 01 April 2009
View article titled, Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
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Includes: Supplementary data
Journal Articles

Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer

Ceshi Chen, Arun K. Seth, Andrew E. Aplin
Journal: Molecular Cancer Research
Mol Cancer Res (2006) 4 (10): 695–707.
https://doi.org/10.1158/1541-7786.MCR-06-0182
Published: 01 October 2006
View article titled, Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer
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