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Tumor Microenvironment and Immunobiology March 26 2025

Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes

Yuhan Qiu; Andrew Chen; Rebecca Yu; Pablo Llevenes; Michael Seen; Naomi Y. Ko; Stefano Monti; Gerald V. Denis

Mol Cancer Res (2025)

View articletitled, Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes

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Cancer Genes and Networks March 25 2025

Extrachromosomal DNA Dynamics Contribute to Intratumoral Receptor Tyrosine Kinase Genetic Heterogeneity and Drug Resistance in Gastric Cancer

Kazuki Kanayama; Hiroshi Imai; Ryotaro Hashizume; Chise Matsuda; Eri Usugi; Yoshifumi S. Hirokawa; Masatoshi Watanabe

Mol Cancer Res (2025)

View articletitled, Extrachromosomal DNA Dynamics Contribute to Intratumoral Receptor Tyrosine Kinase Genetic Heterogeneity and Drug Resistance in Gastric Cancer

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Research Article March 19 2025

Single-cell and spatial transcriptomics reveal a tumor-associated macrophage subpopulation that mediates prostate cancer progression and metastasis

Shenglin Mei; Hanyu Zhang; Taghreed Hirz; Nathan Elias Jeffries; Yanxin Xu; Ninib Baryawno; Shulin Wu; Chin-Lee Wu; Akash Patnaik; Philip J. Saylor; David B. Sykes; Douglas M. Dahl

Mol Cancer Res (2025)

View articletitled, Single-cell and spatial transcriptomics reveal a tumor-associated macrophage subpopulation that mediates prostate cancer progression and metastasis

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Research Article March 17 2025

Empty spiracles homeobox 2 (EMX2) transcription factor functions as a tumor suppressor in renal cell carcinoma by targeting CADM1

Zhibin Fu; Wenqi Chen; Di Gu; Juan Li; Kai Dong; Yuying Lan; Tao Liu; Bianhong Zhang; Lei Li; Ethan Lee; Chenghua Yang; Tao P. Zhong; Linhui Wang

Mol Cancer Res (2025)

View articletitled, Empty spiracles homeobox 2 (EMX2) transcription factor functions as a tumor suppressor in renal cell carcinoma by targeting CADM1

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Review March 12 2025

Epigenetic Dysregulation of Retrotransposons in Cancer

Kwok Yu Liu; Danny Leung

Mol Cancer Res (2025)

View articletitled, Epigenetic Dysregulation of Retrotransposons in Cancer

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Cancer Genes and Networks March 12 2025

SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53–KRAS Oncogenic Synergy

Paramita Ray; Shirish Shukla; Yaqing Zhang; Katelyn L. Donahue; Derek J. Nancarrow; Srimathi Kasturirangan; Sunita Shankar; Kyle Cuneo; Dafydd Thomas; Shirish M. Gadgeel; Theodore S. Lawrence; Marina Pasca di Magliano; Dipankar Ray

Mol Cancer Res (2025)

View articletitled, SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53–KRAS Oncogenic Synergy

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Signal Transduction and Functional Imaging March 12 2025

KSR1 Mediates Small Cell Lung Carcinoma Tumor Initiation and Cisplatin Resistance

Deepan Chatterjee; Robert A. Svoboda; Dianna H. Huisman; Benjamin J. Drapkin; Heidi M. Vieira; Chaitra Rao; James W. Askew; Kurt W. Fisher; Robert E. Lewis

Mol Cancer Res (2025)

View articletitled, KSR1 Mediates Small Cell Lung Carcinoma Tumor Initiation and Cisplatin Resistance

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Cancer Genes and Networks March 12 2025

SIRT2 Regulates the SMARCB1 Loss-Driven Differentiation Block in ATRT

Irina Alimova; Dong Wang; John DeSisto; Etienne Danis; Senthilnath Lakshmanachetty; Eric Prince; Gillian Murdock; Angela Pierce; Andrew Donson; Ilango Balakrishnan; Natalie Serkova; Hening Lin; Nicholas K. Foreman; Nathan Dahl; Sujatha Venkataraman; Rajeev Vibhakar

Mol Cancer Res (2025)

View articletitled, SIRT2 Regulates the SMARCB1 Loss-Driven Differentiation Block in ATRT

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Tumor Microenvironment and Immunobiology March 12 2025

Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion

Wei Wang; Rahul Chaudhary; Justin Szpendyk; Lamyae El Khalki; Neelum Aziz Yousafzai; Ricky Chan; Amar Desai; Khalid Sossey-Alaoui

Mol Cancer Res (2025)

View articletitled, Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion

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Research Article March 10 2025

KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma

Dianna H. Huisman; Deepan Chatterjee; Robert A. Svoboda; Heidi M. Vieira; Abbie S. Ireland; Sydney Skupa; James W. Askew; Danielle E. Frodyma; Luc Girard; Kurt W. Fisher; Michael S. Kareta; John D. Minna; Trudy G. Oliver; Robert E. Lewis

Mol Cancer Res (2025)

View articletitled, KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma

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Research Article March 7 2025

ANGEL2 modulates wildtype TP53 translation and doxorubicin chemosensitivity in colon cancer

Christopher August Lucchesi; Saisamkalpa Mantrala; Darren Tran; Neelu Batra; Avani Durve; Conner Suen; Jin Zhang; Paramita Ghosh; Xinbin Chen

Mol Cancer Res (2025)

View articletitled, ANGEL2 modulates wildtype TP53 translation and doxorubicin chemosensitivity in colon cancer

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Research Article March 6 2025

Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine Resistant Multiple Myeloma

Zachary J. Walker; Katherine F. Vaeth; Amber Baldwin; Denis J. Ohlstrom; Lauren T. Reiman; Kady A. Dennis; Kate Matlin; Beau M. Idler; Brett M. Stevens; Neelanjan Mukherjee; Daniel W. Sherbenou

Mol Cancer Res (2025)

View articletitled, Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine Resistant Multiple Myeloma

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Cancer Research Resources March 4 2025

Exome Sequencing Reveals a Sparse Genomic Landscape in Kaposi Sarcoma

Warren Phipps; Bhavneet Bhinder; Andrea Towlerton; Peter Mooka; James Kafeero; Matt Fitzgibbon; Olivier Elemento; Ethel Cesarman

Mol Cancer Res (2025)

View articletitled, Exome Sequencing Reveals a Sparse Genomic Landscape in Kaposi Sarcoma

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Cancer Genes and Networks February 26 2025

RNF6 Inhibits Lung Adenocarcinoma Cell Proliferation by Promoting Cyclin D2 Degradation

Yuening Sun; Liyang Jiang; Zubin Zhang; Rongrong Zhu; Jingpei Liang; Ziyang Liu; Yuanming He; Zhenqian Huang; Chunhua Ling; Xiumin Zhou; Xinliang Mao

Mol Cancer Res (2025)

View articletitled, RNF6 Inhibits Lung Adenocarcinoma Cell Proliferation by Promoting Cyclin D2 Degradation

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Cancer Genes and Networks February 26 2025

ATAD2 Drives Prostate Cancer Progression to Metastasis

Anindita Dutta; Antonio Rodriguez-Calero; Kacey Ronaldson-Bouchard; Anne Offermann; Daoud Rahman; Twinkle Bapuji Vhatkar; Dan Hasson; Mohammed Alshalalfa; Elai Davicioni; R. Jeffrey Karnes; Mark A. Rubin; Gordana Vunjak-Novakovic; Cory Abate-Shen; Juan Martin Arriaga

Mol Cancer Res (2025)

View articletitled, ATAD2 Drives Prostate Cancer Progression to Metastasis

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Tumor Microenvironment and Immunobiology February 26 2025

THG-1/TSC22D4 Promotes IL-1 Signaling through Stabilization of TRAF6 in Squamous Cell Carcinoma

Yasuhito Okano; Hiroyuki Suzuki; Yukihide Watanabe; Mohammed Abdelaziz; Lev Manevich; Kunio Kawanishi; Haruka Ozaki; Ryota Ishii; Shin Matsumoto; Nohara Goto; Ling Zheng; Yukari Okita; Jongchan Hwang; Masahiro Nakayama; Yoshihide Shima; Noriaki Sakamoto; Masayuki Noguchi; Keiji Tabuchi; Mitsuyasu Kato

Mol Cancer Res (2025)

View articletitled, THG-1/TSC22D4 Promotes IL-1 Signaling through Stabilization of TRAF6 in Squamous Cell Carcinoma

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Review February 26 2025

Tumor Microenvironment: Obstacles and Opportunities for T Cell–Based Tumor Immunotherapies

Miao-Miao Hu; Ying Zhao; Nan Zhang; Fang-Yuan Gong; Wei Zhang; Chun-Sheng Dong; Jian-Feng Dai; Jun Wang

Mol Cancer Res (2025)

View articletitled, Tumor Microenvironment: Obstacles and Opportunities for T Cell–Based Tumor Immunotherapies

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Cancer Genes and Networks February 26 2025

PAX8 Interacts with the SWI/SNF Complex at Enhancers to Drive Proliferation in Ovarian Cancer

Kostianna Sereti; Anna E. Russo; Ryan Raisner; Taylur P. Ma; Karen E. Gascoigne

Mol Cancer Res (2025)

View articletitled, PAX8 Interacts with the SWI/SNF Complex at Enhancers to Drive Proliferation in Ovarian Cancer

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Minireview February 13 2025

The Role of WDR77 in Cancer: More than a PRMT5 Interactor

Isaac Silverman; Aaron Shaykevich; Radhashree Maitra

Mol Cancer Res (2025)

View articletitled, The Role of WDR77 in Cancer: More than a PRMT5 Interactor

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Cancer Genes and Networks February 12 2025

Exploiting YES1-Driven EGFR Expression Improves the Efficacy of EGFR Inhibitors

Leslie Cuellar-Vite; Elyse M. Donaubauer; Kristen L. Weber-Bonk; Jessica R. Bobbitt; Natasha N. Ingles; Taylor L. Brzozowski; Fadi W. Abdul-Karim; Christine N. Booth; Ruth A. Keri

Mol Cancer Res (2025)

View articletitled, Exploiting YES1-Driven EGFR Expression Improves the Efficacy of EGFR Inhibitors

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Cancer Genes and Networks February 12 2025

Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon

Daniela Araiza-Olivera; Tatiana Y. Prudnikova; Cristina Uribe-Alvarez; Kathy Q. Cai; Janusz Franco-Barraza; Jesus M. Dones; Ronald T. Raines; Jonathan Chernoff

Mol Cancer Res (2025)

View articletitled, Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon

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Cancer Genes and Networks February 6 2025

Intracellular Retention of Estradiol Is Mediated by GRAM Domain–Containing Protein ASTER-B in Breast Cancer Cells

Hyung Bum Kim; W. Lee Kraus

Mol Cancer Res (2025)

View articletitled, Intracellular Retention of Estradiol Is Mediated by GRAM Domain–Containing Protein ASTER-B in Breast Cancer Cells

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Cell Fate Decisions January 29 2025

Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities

Ning Kang; Hui Xue; Nelson K.Y. Wong; Yen-Yi Lin; Adam Classen; Rebecca Wu; Htoo Zarni Oo; Xin Dong; Angela Trinh; Dong Lin; Mads Daugaard; Christopher Ong; Colin Collins; Martin Gleave; Yuzhuo Wang

Mol Cancer Res (2025)

View articletitled, Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities

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New Horizons in Cancer Biology January 22 2025

Lysosomal–Mitochondrial Interaction Promotes Tumor Growth in Squamous Cell Carcinoma of the Head and Neck

Avani Gopalkrishnan; Nathaniel Wang; Silvia Cruz-Rangel; Abdul Yassin-Kassab; Sruti Shiva; Chareeni Kurukulasuriya; Satdarshan P. Monga; Ralph J. DeBerardinis; Heath D. Skinner; Kirill Kiselyov; Umamaheswar Duvvuri

Mol Cancer Res (2025)

View articletitled, Lysosomal–Mitochondrial Interaction Promotes Tumor Growth in Squamous Cell Carcinoma of the Head and Neck

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Cancer Genes and Networks January 22 2025

Coevolution of Atypical BRAF and KRAS Mutations in Colorectal Tumorigenesis

Connor E. Woolley; Enric Domingo; Juan Fernandez-Tajes; Kathryn A.F. Pennel; Patricia Roxburgh; Joanne Edwards; Susan D. Richman; Tim S. Maughan; David J. Kerr; Ignacio Soriano; Ian P.M. Tomlinson

Mol Cancer Res (2025)

View articletitled, Coevolution of Atypical <em>BRAF</em> and <em>KRAS</em> Mutations in Colorectal Tumorigenesis

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Cancer Genes and Networks January 15 2025

Bmal1-Mediated Circadian MELK Expression Potentiates MELK Inhibitor Chronotherapy for Esophageal Cancer

Boning Zeng; Chao Sun; Qian Tang; Nan Li; Siying Chen; Yili Yang; Xiao Wang; Shaoxiang Wang

Mol Cancer Res (2025)

View articletitled, Bmal1-Mediated Circadian MELK Expression Potentiates MELK Inhibitor Chronotherapy for Esophageal Cancer

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Tumor Microenvironment and Immunobiology January 8 2025

Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma

Scott D. Varney; Dan A. Erkes; Glenn L. Mersky; Manal U. Mustafa; Vivian Chua; Inna Chervoneva; Timothy J. Purwin; Emad Alnemri; Andrew E. Aplin

Mol Cancer Res (2025)

View articletitled, Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma

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Research Article March 19 2024

DR5 disulfide bonding functions as a sensor and effector of protein folding stress

Mol Cancer Res (2024)

View articletitled, DR5 disulfide bonding functions as a sensor and effector of protein folding stress

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OnlineFirst

Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes

Extrachromosomal DNA Dynamics Contribute to Intratumoral Receptor Tyrosine Kinase Genetic Heterogeneity and Drug Resistance in Gastric Cancer

Single-cell and spatial transcriptomics reveal a tumor-associated macrophage subpopulation that mediates prostate cancer progression and metastasis

Empty spiracles homeobox 2 (EMX2) transcription factor functions as a tumor suppressor in renal cell carcinoma by targeting CADM1

Epigenetic Dysregulation of Retrotransposons in Cancer

SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53–KRAS Oncogenic Synergy

KSR1 Mediates Small Cell Lung Carcinoma Tumor Initiation and Cisplatin Resistance

SIRT2 Regulates the SMARCB1 Loss-Driven Differentiation Block in ATRT

Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion

KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma

ANGEL2 modulates wildtype TP53 translation and doxorubicin chemosensitivity in colon cancer

Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine Resistant Multiple Myeloma

Exome Sequencing Reveals a Sparse Genomic Landscape in Kaposi Sarcoma

RNF6 Inhibits Lung Adenocarcinoma Cell Proliferation by Promoting Cyclin D2 Degradation

ATAD2 Drives Prostate Cancer Progression to Metastasis

THG-1/TSC22D4 Promotes IL-1 Signaling through Stabilization of TRAF6 in Squamous Cell Carcinoma

Tumor Microenvironment: Obstacles and Opportunities for T Cell–Based Tumor Immunotherapies

PAX8 Interacts with the SWI/SNF Complex at Enhancers to Drive Proliferation in Ovarian Cancer

The Role of WDR77 in Cancer: More than a PRMT5 Interactor

Exploiting YES1-Driven EGFR Expression Improves the Efficacy of EGFR Inhibitors

Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon

Intracellular Retention of Estradiol Is Mediated by GRAM Domain–Containing Protein ASTER-B in Breast Cancer Cells

Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities

Lysosomal–Mitochondrial Interaction Promotes Tumor Growth in Squamous Cell Carcinoma of the Head and Neck

Coevolution of Atypical BRAF and KRAS Mutations in Colorectal Tumorigenesis

Bmal1-Mediated Circadian MELK Expression Potentiates MELK Inhibitor Chronotherapy for Esophageal Cancer

Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma

DR5 disulfide bonding functions as a sensor and effector of protein folding stress

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