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1 August 2011
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Cover Image
Age-related changes in the microenvironment are hypothesized to impact tumorigenesis. Osteopontin (green) is expressed in stromal fibroblasts coincident with the cell cycle inhibitor p21 (red) and p16 (data not shown) in a preneoplastic actinic keratosis skin lesion. Because osteopontin stimulates preneoplastic cell growth in vitro and in xenografts, this finding suggests that stromal-derived osteopontin plays a role in human cancer. For further details, please see Luo and coworkers on page 1018 in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1541-7786
EISSN 1557-3125
Highlights
Perspective
Subject Review
Angiogenesis, Metastasis, and the Cellular Microenvironment
Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers
Andrew J. Armstrong; Matthew S. Marengo; Sebastian Oltean; Gabor Kemeny; Rhonda L. Bitting; James D. Turnbull; Christina I. Herold; Paul K. Marcom; Daniel J. George; Mariano A. Garcia-Blanco
Cancer Genes and Genomics
c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells
Antonio Porro; Nunzio Iraci; Simona Soverini; Daniel Diolaiti; Samuele Gherardi; Carolina Terragna; Sandra Durante; Emanuele Valli; Thea Kalebic; Roberto Bernardoni; Chiara Perrod; Michelle Haber; Murray D. Norris; Michele Baccarani; Giovanni Martinelli; Giovanni Perini
Cell Cycle, Cell Death, and Senescence
DNA Damage and Cellular Stress Responses
Signaling and Regulation
Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer
Elizabeth R. Burton; Aneesa Gaffar; Soo Jin Lee; Folashade Adeshuko; Kathleen D. Whitney; Joon-Yong Chung; Stephen M. Hewitt; Gloria S. Huang; Gary L. Goldberg; Steven K. Libutti; Mijung Kwon
Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells
Biola M. Javierre; Javier Rodriguez-Ubreva; Fatima Al-Shahrour; Marina Corominas; Osvaldo Graña; Laura Ciudad; Xabier Agirre; David G. Pisano; Alfonso Valencia; Jose Roman-Gomez; Maria Jose Calasanz; Felipe Prosper; Manel Esteller; Rogelio Gonzalez-Sarmiento; Esteban Ballestar
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