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1 April 2011
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Ribonucleotide reductase 1 (Rnr1) is a key component of the DNA damage response and its regulation controls dNTP levels. Using fluorescence microscopy and molecular approaches, it was found that Rnr1 is packaged in an autophagosome and targeted to the vacuole in response to TOR inhibition. Defects in autophagy prevent packaging and targeting of Rnr1 and lead to increased Rnr1 protein levels and a DNA damage phenotype. For further details, please see Dyavaiah and colleagues on page 462 in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1541-7786
EISSN 1557-3125
Highlights
Angiogenesis, Metastasis, and the Cellular Microenvironment
Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway
Shu-Guang Liu; Bo-Shi Wang; Yan-Yi Jiang; Tong-Tong Zhang; Zhi-Zhou Shi; Yang Yang; Yi-Ling Yang; Xiao-Chun Wang; De-Chen Lin; Yu Zhang; Hai Yang; Yan Cai; Qi-Min Zhan; Ming-Rong Wang
Cell Cycle, Cell Death, and Senescence
DNA Damage and Cellular Stress Responses
Signaling and Regulation
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