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1 March 2010
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Cover Image
Small molecules targeting Aurora A kinase have entered Phase I/II clinical trials. This article shows for the first time that inhibition of Aurora A kinase, using the small molecule inhibitor MLN8054, results in senescence both in vitro and in vivo. Senescent cells are characterized by a large, flat cellular morphology. Shown on the cover are senescent HCT-116 xenograft tumor cells from a mouse treated with MLN8054 [blue DNA stain (DAPI ) and green tubulin stain (cytoplasm)]. For further details and information on additional senescence markers, please see the article by Huck and coworkers on page 373 in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1541-7786
EISSN 1557-3125
Highlights
Review
Angiogenesis, Metastasis, and the Cellular Microenvironment
The COOH-Terminal Peptide of Platelet Factor-4 Variant (CXCL4L1/PF-4var47-70) Strongly Inhibits Angiogenesis and Suppresses B16 Melanoma Growth In vivo
Jo Vandercappellen; Sandra Liekens; Annelies Bronckaers; Samuel Noppen; Isabelle Ronsse; Chris Dillen; Mirella Belleri; Stefania Mitola; Paul Proost; Marco Presta; Sofie Struyf; Jo Van Damme
Cancer Genes and Genomics
Cell Cycle, Cell Death, and Senescence
DNA Damage and Cellular Stress Responses
Signaling and Regulation
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