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1 October 2010
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Cover Image
Cover Image
Survival or death of cancer cells after inducing DNA damage has always been a challenge to predict because what decides the survival or death of a DNA-damaged cell has not been unraveled. The figure depicts a new mechanism by which a small heat shock protein, Hsp27, can influence the dying cells to survive by modulating the dynamics of p21 translocation from cytoplasm to nucleus. This novel finding may provide new insights in understanding how cancer cells escape to survive after treatment. For further details, please see Kanagasabai and coworkers on page 1399 in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1541-7786
EISSN 1557-3125
Highlights
Angiogenesis, Metastasis, and the Cellular Microenvironment
EphB4 Promotes Site-Specific Metastatic Tumor Cell Dissemination by Interacting with Endothelial Cell–Expressed EphrinB2
Mélanie Héroult; Florence Schaffner; Dennis Pfaff; Claudia Prahst; Robert Kirmse; Simone Kutschera; Maria Riedel; Thomas Ludwig; Peter Vajkoczy; Ralph Graeser; Hellmut G. Augustin
Macrophage Migration Inhibitory Factor Is Secreted by Rhabdomyosarcoma Cells, Modulates Tumor Metastasis by Binding to CXCR4 and CXCR7 Receptors and Inhibits Recruitment of Cancer-Associated Fibroblasts
Maciej Tarnowski; Katarzyna Grymula; Rui Liu; Joanna Tarnowska; Justyna Drukala; Janina Ratajczak; Robert A. Mitchell; Mariusz Z. Ratajczak; Magda Kucia
Cancer Genes and Genomics
Cell Cycle, Cell Death, and Senescence
DNA Damage and Cellular Stress Responses
Signaling and Regulation
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