Filopodia are dynamic protrusions of the plasma membrane that are important mechanisms for altering cell motility and that play a pivotal role in cancer cell migration and invasion. Using rhodamine-conjugated phalloidin to visualize F-actin distributions and actin cytoskeleton reorganization, it was found that galectin-1 overexpression in OC-2 cells, an oral squamous cell carcinoma cell line, significantly increased the frequency and length of filopodia and promoted tumor invasion and metastasis. For details, see the article by Wu and colleagues on page 311.