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1 October 2009
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Immunofluorescence analysis demonstrates the subcellular colocalization and the spatial association of the core protein of hepatitis B virus (HBV-core, red), the tumor suppressor PML (green), and the chromatin modulator HDAC1 (blue) in PML-nuclear bodies in an HBV-expressing hepatoma cell. The interactions of HBV-core, PML, and HDAC1 affect the PML activity in gene transcription and induction of apoptosis. For details, see the article by Chung and Tsai on page 1672.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1541-7786
EISSN 1557-3125
Angiogenesis, Metastasis, and the Cellular Microenvironment
Cancer Genes and Genomics
A Novel DNMT3B Splice Variant Expressed in Tumor and Pluripotent Cells Modulates Genomic DNA Methylation Patterns and Displays Altered DNA Binding
Suhasni Gopalakrishnan; Beth O. Van Emburgh; Jixiu Shan; Zhen Su; C. Robert Fields; Johannes Vieweg; Takashi Hamazaki; Philip H. Schwartz; Naohiro Terada; Keith D. Robertson
Cell Cycle, Cell Death, and Senescence
Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer
Chi-Iou Lin; Edward E. Whang; David B. Donner; Xiaofeng Jiang; Brendan D. Price; Adelaide M. Carothers; Tamara Delaine; Hakon Leffler; Ulf J. Nilsson; Vania Nose; Francis D. Moore,, Jr.; Daniel T. Ruan
DNA Damage and Cellular Stress Responses
Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways
Xuesong Liu; Edward K. Han; Mark Anderson; Yan Shi; Dimitri Semizarov; Gang Wang; Thomas McGonigal; Lisa Roberts; Loren Lasko; Joann Palma; Gui-dong Zhu; Thomas Penning; Saul Rosenberg; Vincent L. Giranda; Yan Luo; Joel Leverson; Eric F. Johnson; Alexander R. Shoemaker
Signaling and Regulation
H3 Histamine Receptor–Mediated Activation of Protein Kinase Cα Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo
Heather Francis; Paolo Onori; Eugenio Gaudio; Antonio Franchitto; Sharon DeMorrow; Julie Venter; Shelley Kopriva; Guido Carpino; Romina Mancinelli; Mellanie White; Fanyin Meng; Antonella Vetuschi; Roberta Sferra; Gianfranco Alpini
Reconstitution of Amphiregulin–Epidermal Growth Factor Receptor Signaling in Lung Squamous Cell Carcinomas Activates PTHrP Gene Expression and Contributes to Cancer-Mediated Diseases of the Bone
Jennifer L. Gilmore; Ryan M. Gonterman; Keshav Menon; Gwendolen Lorch; David J. Riese, II; Alex Robling; John Foley
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