Expression of the ADAM-15A variant enhances breast cancer cell adhesion and migration. Actin stress fibers are shown by rhodamine-phalloidin staining (red) in a MDA-MB-435 cell stably transfected with the ADAM-15A cytoplasmic tail variant and by immunostaining localized focal adhesion kinase (green). For details, see the article by Zhong and colleagues on page 383.