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1 March 2023
Cover ImageGene expression-based consensus molecular subtypes (CMS) provide mechanistic, prognostic, and therapeutic insights in colorectal cancer. However, the original four subtypes were defined using bulk transcriptomic data, such that intra-subtype heterogeneity and cell type contributions are not fully clarified. In their study on page 240, Bhukdee and colleagues employed computational representation learning and single-cell transcriptomic dataset comparisons to impart higher resolution to CMS and their constituent genes and cell types. The authors' analyses produced a 62-gene panel that identifies 3 novel subtypes within 2 existing CMS, and single-cell transcriptomic data imposition onto the panel elucidates tumor and non-tumor cell contributions to the subtypes. The cover image is a 2-dimensional densMAP visualization of the 4 original and 3 novel subtypes using the identified 62-gene panel, where each subtype is designated with a unique color. The presented analyses and gene panel further delineate molecular mechanisms underlying colorectal cancer and may enhance the power of CMS to inform disease prognoses and therapeutic strategies.Close Modal
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Molecular Cancer Research (2002-Present; volumes 1-current)(ISSN 0008-5472) Published monthly since November, 2002.
Cell Growth & Differentiation (1990-2002; volumes 1-13)(ISSN 1044-9523) Published monthly 1990- September, 2002.
Table of Contents
Cancer Genes and Networks
Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells
Noreen McBrearty; Christina Cho; Jinyun Chen; Farima Zahedi; Amy R. Peck; Enrico Radaelli; Charles-Antoine Assenmacher; Clarice Pavlak; Anne Devine; Pengfei Yu; Zhen Lu; Hongru Zhang; Jinyang Li; Jason R. Pitarresi; Igor Astsaturov; Edna Cukierman; Anil K. Rustgi; Ben Z. Stanger; Hallgeir Rui; Serge Y. Fuchs
The Prostate Stromal Transcriptome in Aggressive and Lethal Prostate Cancer
Chaoran Ma; Yinglu Zhou; Giuseppe Nicolò Fanelli; Konrad H. Stopsack; Michelangelo Fiorentino; Giorgia Zadra; Lorelei A. Mucci; Massimo Loda; Svitlana Tyekucheva; Kathryn L. Penney
New Horizons in Cancer Biology
MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer
Nami Yamashita; Yoshihiro Morimoto; Atsushi Fushimi; Rehan Ahmad; Atrayee Bhattacharya; Tatsuaki Daimon; Naoki Haratake; Yuka Inoue; Satoshi Ishikawa; Masaaki Yamamoto; Tsuyoshi Hata; Sayuri Akiyoshi; Qiang Hu; Tao Liu; Henry Withers; Song Liu; Geoffrey I. Shapiro; Tomoharu Yoshizumi; Mark D. Long; Donald Kufe