Issues
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Cover Image
Cover Image
Although oncogenic signaling is required for tumorigenesis, it paradoxically can induce oncogene-induced senescence (OIS). How tumors bypass OIS and progress is poorly understood. In their study on page 770, Dutchak and colleagues employed a myristoylated kinase/kinase regulator screen in an in vitro OIS model and found that kinase regulator Mps-one binder co-activator 3A (MOB3A) promotes proliferation despite constitutive BRAF signaling that otherwise induces OIS. The authors went on to demonstrate that MOB3A subverts OIS by deactivating Hippo pathway signaling and inducing YAP/TAZ-mediated transcriptional activation. The cover depicts a merged immunofluorescent image of HEK-293T cells transfected with myristoylated MOB3A, where MOB3A fluoresces green, YAP/TAZ fluoresces red, and nuclei fluoresce blue. MOB3A-induced YAP/TAZ nuclear localization causes nuclei to fluoresce light blue in the merged image. The authors went on to show that shRNA-mediated MOB3A silencing slows tumor growth in vivo, presenting MOB3A as a novel potential therapeutic target. This article is also Highlighted on page 671. - PDF Icon PDF LinkTable of Contents
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Molecular Cancer Research
Table of Contents
Highlights
Cancer Genes and Networks
Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer
HIPK2 Cooperates with KRAS Signaling and Associates with Colorectal Cancer Progression
Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition
Cancer “-omics”
Branching Copy-Number Evolution and Parallel Immune Profiles across the Regional Tumor Space of Resected Pancreatic Cancer
Cell Fate Decisions
Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications
Plasticity within Aldehyde Dehydrogenase–Positive Cells Determines Prostate Cancer Radiosensitivity
Signal Transduction and Functional Imaging
Tumor Microenvironment and Immunobiology
Journal Archive
Molecular Cancer Research
(2002-Present; volumes 1-current)Published monthly since November, 2002.
(ISSN 0008-5472)
Cell Growth & Differentiation
(1990-2002; volumes 1-13)Published monthly 1990- September, 2002.
(ISSN 1044-9523)
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