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1 January 2022
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Cover Image
Cover Image
Angiogenesis is critical for tumor nutrient access and progression, rendering it an attractive therapeutic target. To date, antiangiogenic therapies have lacked success due to side effects and therapeutic resistance. Therefore, antiangiogenic therapy may be enhanced using novel molecular targets that regulate angiogenesis and other oncogenic processes. In their study on page 77, Kumar and colleagues demonstrate that in addition to previously established roles in epithelial–mesenchymal transition and poor patient outcomes, IQGAP2 suppression induces breast tumor angiogenesis. The cover depicts an ImageJ Angiogenesis Analyzer image of human umbilical vein endothelial cell tubules in culture with conditioned medium from breast cancer cells in which IQGAP2 expression has been reduced using shRNA. This article is also Highlighted on page 1.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1541-7786
EISSN 1557-3125
Highlights
Minireview
Reviews
Rapid Impact
Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy
Mark Lee; Brian R. Untch; Bin Xu; Ronald Ghossein; Catherine Han; Fengshen Kuo; Cristina Valero; Zaineb Nadeem; Neal Patel; Vladimir Makarov; Snjezana Dogan; Richard J. Wong; Eric J. Sherman; Alan L. Ho; Timothy A. Chan; James A. Fagin; Luc G.T. Morris
Cancer Genes and Networks
GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer
Marieke Burleson; Janice J. Deng; Tai Qin; Thu Minh Duong; Yuqian Yan; Xiang Gu; Debodipta Das; Acarizia Easley; Michael A. Liss; P. Renee Yew; Roble Bedolla; Addanki Pratap Kumar; Tim Hui-Ming Huang; Yi Zou; Yidong Chen; Chun-Liang Chen; Haojie Huang; Lu-Zhe Sun; Thomas G. Boyer
Cancer “-omics”
Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer
Samah El Ghamrasni; Rene Quevedo; James Hawley; Parisa Mazrooei; Youstina Hanna; Iulia Cirlan; Helen Zhu; Jeff P. Bruce; Leslie E. Oldfield; S.Y. Cindy Yang; Paul Guilhamon; Jüri Reimand; Dave W. Cescon; Susan J. Done; Mathieu Lupien; Trevor J. Pugh
Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway
Aisha Naeem; Varsha Harish; Sophie Coste; Erika M. Parasido; Muhammad Umer Choudhry; Lawrence F. Kromer; Chukuemeka Ihemelandu; Emanuel F. Petricoin; Mariaelena Pierobon; Muhammad Saad Noon; Venkata Mahidhar Yenugonda; Maria Avantaggiati; Gary M. Kupfer; Stanley Fricke; Olga Rodriguez; Chris Albanese
New Horizons in Cancer Biology
A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
Aditya Wirawan; Ken Tajima; Fumiyuki Takahashi; Yoichiro Mitsuishi; Wira Winardi; Moulid Hidayat; Daisuke Hayakawa; Naohisa Matsumoto; Kenta Izumi; Tetsuhiko Asao; Ryo Ko; Naoko Shimada; Kazuya Takamochi; Kenji Suzuki; Masaaki Abe; Okio Hino; Yoshitaka Sekido; Kazuhisa Takahashi
Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma
Sanchareeka Dey; Adnin Ashrafi; Chantal Vidal; Nivesh Jain; Sarada Preeta Kalainayakan; Poorva Ghosh; Parinaz Sadat Alemi; Narges Salamat; Purna Chaitanya Konduri; Jung-whan Kim; Li Zhang
Signal Transduction and Functional Imaging
Tumor Microenvironment and Immunobiology
Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Deng-Ke Li; Xing-Rui Chen; Li-Na Wang; Jia-Hong Wang; Yue-Ting Wen; Zi-Ying Zhou; Ji-Ke Li; Jing-Xian Liu; Lin-Bo Cai; Shui-Sheng Zhong; Xiao-Ming Lyu; Faleti Oluwasijibomi Damola; Min-Ying Li; Jing-Jing Zhang; Yu-Mei Zeng; Qian-Li Wang; Qian-Bing Zhang; Hao Lyu; Xiao-Yan Fu; Wei Wang; Xin Li; Zhong-Xi Huang; Kai-Tai Yao
Correction
Acknowledgment to Reviewers
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