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1 August 2021
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Cover Image
Cover Image
Invasive lobular carcinoma of the breast (ILC) is the most common special subtype of breast cancer, and though nearly all ILC express estrogen receptor alpha (ERα), ILC represent a distinct context for ERα function among breast cancers. The cover depicts a stylized immunofluorescence image showing DNA damage foci to which Mediator of DNA Damage Checkpoint 1 (MDC1) has localized. MDC1 canonically acts in the DNA damage response. However, in their study on page 1270, Sottnik, Bordeaux, and colleagues provide evidence that MDC1 also has novel ERα co-regulator activity and is critical for ERα function in ILC cells. The authors argue that canonical functions of MDC1 in DNA repair may be superseded by novel ERα co-regulator activity in this context. Artwork by Kristine M. Sikora, PhD. - PDF Icon PDF LinkTable of Contents
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ISSN 1541-7786
EISSN 1557-3125
Molecular Cancer Research
Table of Contents
Highlights
Review
Cancer Genes and Networks
EGR1 Addiction in Diffuse Large B-cell Lymphoma
Shuichi Kimpara; Li Lu; Nguyet M. Hoang; Fen Zhu; Paul D. Bates; Anusara Daenthanasanmak; Shanxiang Zhang; David T. Yang; Amanda Kelm; Yunxia Liu; Yangguang Li; Alexander Rosiejka; Apoorv Kondapelli; Samantha Bebel; Madelyn Chen; Thomas A. Waldmann; Christian M. Capitini; Lixin Rui
Cancer “-omics”
Genome Maintenance
Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor
Liliya Tyutyunyk-Massey; Yilun Sun; Nga Dao; Hannah Ngo; Mallika Dammalapati; Ashish Vaidyanathan; Manjulata Singh; Syed Haqqani; Joshua Haueis; Ryan Finnegan; Xiaoyan Deng; Steve E. Kirberger; Paula D. Bos; Dipankar Bandyopadhyay; William C.K. Pomerantz; Yves Pommier; David A. Gewirtz; Joseph W. Landry
R-Loop–Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin
Maryam Safari; Thomas Litman; Robert W. Robey; Andrés Aguilera; Arup R. Chakraborty; William C. Reinhold; Agnes Basseville; Lubov Petrukhin; Luigi Scotto; Owen A. O'Connor; Yves Pommier; Antonio T. Fojo; Susan E. Bates
Metabolism
Elevated Asparagine Biosynthesis Drives Brain Tumor Stem Cell Metabolic Plasticity and Resistance to Oxidative Stress
Tom M. Thomas; Ken Miyaguchi; Lincoln A. Edwards; Hongqiang Wang; Hassen Wollebo; Li Aiguo; Ramachandran Murali; Yizhou Wang; Daniel Braas; Justin S. Michael; Allen M. Andres; Miqin Zhang; Kamel Khalili; Roberta A. Gottlieb; J. Manuel Perez; John S. Yu
New Horizons in Cancer Biology
RNA Biology
Tumor Microenvironment and Immunobiology
Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model
Rajaa El Meskini; Devon Atkinson; Alan Kulaga; Abdalla Abdelmaksoud; Michelle Gumprecht; Nathan Pate; Susana Hayes; Michael Oberst; Ian M. Kaplan; Patrick Raber; Terry Van Dyke; Shyam K. Sharan; Robert Hollingsworth; Chi-Ping Day; Glenn Merlino; Zoë Weaver Ohler
Corrections
Journal Archive
Molecular Cancer Research
(2002-Present; volumes 1-current)Published monthly since November, 2002.
(ISSN 0008-5472)
Cell Growth & Differentiation
(1990-2002; volumes 1-13)Published monthly 1990- September, 2002.
(ISSN 1044-9523)
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