Skip Nav Destination
Issues
1 February 2021
-
Cover Image
Cover Image
The use of oils as a carrier for lipophilic drugs during intraperitoneal injection is a common practice in biomedical research, but their differential effects on the microenvironment of the injection site has not been studied. The cover depicts macrophages incubated with vegetal oil, which induces cell death by either apoptosis or pyroptosis depending on the oil used (blue, live cells; green, apoptotic cells; red, necrotic cells). The authors conclude that careful selection of carrier oils based on experimental context is critical to the proper interpretation of data derived from intraperitoneal injection models. For more information, see the Highlight on page 165 and the article on page 288.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1541-7786
EISSN 1557-3125
Highlights
Reviews
Rapid Impact
Cancer Genes and Networks
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
Jeffim N. Kuznetsoff; Dawn A. Owens; Andy Lopez; Daniel A. Rodriguez; Nancy T. Chee; Stefan Kurtenbach; Daniel Bilbao; Evan R. Roberts; Claude-Henry Volmar; Claes Wahlestedt; Shaun P. Brothers; J. William Harbour
Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells
Rachel K. Surowiec; Sarah F. Ferris; April Apfelbaum; Carlos Espinoza; Ranjit K. Mehta; Karamoja Monchamp; Veerin R. Sirihorachai; Karan Bedi; Mats Ljungman; Stefanie Galban
Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents
Manman Deng; Zijun Y. Xu-Monette; Lan V. Pham; Xudong Wang; Alexandar Tzankov; Xiaosheng Fang; Feng Zhu; Carlo Visco; Govind Bhagat; Karen Dybkaer; April Chiu; Wayne Tam; Youli Zu; Eric D. Hsi; Hua You; Jooryung Huh; Maurilio Ponzoni; Andrés J.M. Ferreri; Michael B. Møller; Benjamin M. Parsons; Fredrick Hagemeister; J. Han van Krieken; Miguel A. Piris; Jane N. Winter; Yong Li; Bing Xu; Phillip Liu; Ken H. Young
Cell Fate Decisions
Genome Maintenance
Signal Transduction and Functional Imaging
SHOC2 Is a Critical Modulator of Sensitivity to EGFR–TKIs in Non–Small Cell Lung Cancer Cells
Hideki Terai; Junko Hamamoto; Katsura Emoto; Takeshi Masuda; Tadashi Manabe; Satoshi Kuronuma; Keigo Kobayashi; Keita Masuzawa; Shinnosuke Ikemura; Sohei Nakayama; Ichiro Kawada; Yusuke Suzuki; Osamu Takeuchi; Yukio Suzuki; Sumio Ohtsuki; Hiroyuki Yasuda; Kenzo Soejima; Koichi Fukunaga
Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling
Amy R. Dwyer; Carlos Perez Kerkvliet; Raisa I. Krutilina; Hilaire C. Playa; Deanna N. Parke; Warner A. Thomas; Branden A. Smeester; Branden S. Moriarity; Tiffany N. Seagroves; Carol A. Lange
Tumor Microenvironment and Immunobiology
Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft
J. Jason Morton; Nathaniel Alzofon; Stephen B. Keysar; Tugs-Saikhan Chimed; Julie Reisinger; Loni Perrenoud; Phuong N. Le; Cera Nieto; Karina Gomez; Bettina Miller; Randi Yeager; Dexiang Gao; Aik-Choon Tan; Hilary Somerset; Theresa Medina; Xiao-Jing Wang; Jing H. Wang; William Robinson; Dennis R. Roop; Rene Gonzalez; Antonio Jimeno
Advertisement