Proliferative immortality and subversion of the Hayflick limit represents a key hallmark of cancer. In many tumors, this is achieved by elevated expression of telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase holoenzyme which stabilizes telomeres. TERT promoter mutations have been identified as one possible mechanism by which this can be achieved. The cover depicts an Onco-GPS Map of the Cancer Cell Line Encyclopedia, with dots representing the individual cancer samples color-coded according to the enrichment of an epithelial-mesenchymal transition (EMT) transcriptional signature (blue dots indicate a more epithelial signature, while red indicates EMT). The authors found that TERT promoter mutations were tied to gene expression programs that drive cells toward EMT-associated gene expression programs, potentially explaining why this class of mutations is associated with more aggressive cancers and worse outcomes. For more information, see the article on page 1050.