Tumor stroma with an abundance of extracellular matrix (ECM) is characteristic of pancreatic cancer. The cover depicts collagen birefringence from polarized light microscopy of a picrosirius red-stained section of a human pancreatic tumor. Type I collagen appear as yellow-red fibers while Type III collagen fibers appear green. In this issue, Honselmann and colleagues identified the BET family of chromatin adaptor proteins as key regulators of the ECM transcriptional program. Further, the authors demonstrated that pharmacological inhibition of these epigenetic regulators alters the structure of collagen fibers in aggressive tumors to a structure more similar to that observed in tumors from patients with better survival. See the article on page 1889 for more information.