Skip Nav Destination
Issues
1 October 2020
-
Cover Image
Cover Image
Chemotherapy and radiotherapy are key components of the clinical response to pediatric brain tumors, but their use in the context of the developing brain in children comes at a cost: these cytotoxic interventions are also thought to harm proliferating neural stem cells (NSC), thereby causing cognitive impairment in patients. The cover depicts immunofluorescence staining of the neurogenic subventricular zone with NSC markers (GFAP in blue and Sox2 in green), as well as the ion channel Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) 3. In this issue, Johard and colleagues demonstrate that this critical NSC population can be spared from adverse therapeutic side effects by blockade of HCN ion currents without sacrificing antitumor efficacy. For more information, see the Highlight on page 1441 and the article on page 1522. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1541-7786
EISSN 1557-3125
Molecular Cancer Research
Table of Contents
Highlights
Cancer Genes and Networks
Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer
Amro H. Mohammad; Sung-Hoon Kim; Nicholas Bertos; Wissal El-Assaad; Ipshita Nandi; Harvey Smith; Jieyi Yang; Owen J. Chen; Isabelle Gamache; Trisha Rao; Bruno Gagnon; Tina Gruosso; Michel L. Tremblay; Nahum Sonenberg; Marie-Christine Guiot; William Muller; Morag Park; Jose G. Teodoro
Metabolism
Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition
Zeyad D. Nassar; Chui Yan Mah; Margaret M. Centenera; Swati Irani; Martin C. Sadowski; Julia S. Scott; Elizabeth V. Nguyen; Shilpa R. Nagarajan; Max Moldovan; David J. Lynn; Roger J. Daly; Andrew J. Hoy; Lisa M. Butler
New Horizons in Cancer Biology
Author Choice
HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment
Helena Johard; Anna Omelyanenko; Gao Fei; Misha Zilberter; Zankruti Dave; Randa Abu-Youssef; Linnéa Schmidt; Aditya Harisankar; C. Theresa Vincent; Julian Walfridsson; Sven Nelander; Tibor Harkany; Klas Blomgren; Michael Andäng
RNA Biology
The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways
Jianguo Huang; Mohit Sachdeva; Eric Xu; Timothy J. Robinson; Lixia Luo; Yan Ma; Nerissa T. Williams; Omar Lopez; Lisa D. Cervia; Fan Yuan; Xiaodi Qin; Dadong Zhang; Kouros Owzar; Nalan Gokgoz; Andrew Seto; Tomoyo Okada; Samuel Singer; Irene L. Andrulis; Jay S. Wunder; Alexander J. Lazar; Brian P. Rubin; Krista Pipho; Stephano S. Mello; Jimena Giudice; David G. Kirsch
Signal Transduction and Functional Imaging
SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth
Ikrame Lazar; Bertrand Fabre; Yongmei Feng; Ali Khateb; Patrick Turko; Julia M. Martinez Gomez; Dennie T. Frederick; Mitchell P. Levesque; Lea Feld; Gao Zhang; Tongwu Zhang; Brian James; Jeny Shklover; Emily Avitan-Hersh; Ido Livneh; Marzia Scortegagna; Kevin Brown; Ola Larsson; Ivan Topisirovic; Haguy Wolfenson; Meenhard Herlyn; Keith Flaherty; Reinhard Dummer; Ze'ev A. Ronai
Tumor Microenvironment and Immunobiology
Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model
Theresa Hack; Stefanie Bertram; Helen Blair; Verena Börger; Guntram Büsche; Lora Denson; Enrico Fruth; Bernd Giebel; Olaf Heidenreich; Ludger Klein–Hitpass; Laxmikanth Kollipara; Stephanie Sendker; Albert Sickmann; Christiane Walter; Nils von Neuhoff; Helmut Hanenberg; Dirk Reinhardt; Markus Schneider; Mareike Rasche
Journal Archive
Molecular Cancer Research
(2002-Present; volumes 1-current)Published monthly since November, 2002.
(ISSN 0008-5472)
Cell Growth & Differentiation
(1990-2002; volumes 1-13)Published monthly 1990- September, 2002.
(ISSN 1044-9523)
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.