ABOUT THE COVER
The cover image depicts confocal light microscopy of tumor-bearing mouse foot pad tissue. Myelinated epidermal nerve fibers have been labeled with S-100 antibody (red). FITC-Phalloidin reveals actin structure in the skin (green), whereas Hoechst indicates cell nuclei (blue). Cisplatin therapy is associated with reduced numbers of large myelinated epidermal nerve fibers in the skin, leading to loss of sensation. Here, Zhu and colleagues demonstrate that the Rho kinase (ROCK) inhibitor Y-27632 protects myelinated epidermal nerve fibers from cisplatin-induced impairment in mouse foot pad tissue. See the Highlight on page 1775 and the article on page 1910 for more information.