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1 July 2019
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Cover Image
Cover Image
ABOUT THE COVERClose Modal
Hippo pathway signaling through hyperactivated YAP has been shown to promote aggressive phenotypes in uveal melanoma, but its role in cutaneous melanoma is poorly understood. In this issue, Zhang and colleagues demonstrate that YAP is upregulated and hyperactivated in most premalignant melanocytic nevi and malignant melanoma lesions, and it presents a potential therapeutic target in a subset of melanoma patients. Moreover, the authors provide clinical evidence for the first known activating YAP mutations in human cancer. See the article beginning on page 1435 for more information.
The cover depicts co-immunofluorescence staining of a clinical case of cutaneous melanoma (red, Melan-A; green, YAP1; blue, nuclei stained with DAPI). - PDF Icon PDF LinkTable of Contents
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ISSN 1541-7786
EISSN 1557-3125
Highlights
Review
Rapid Impact
Cancer Genes and Networks
Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma
Xiaomeng Zhang; Jian Zhong Tang; Ismael A. Vergara; Youfang Zhang; Pacman Szeto; Lie Yang; Christopher Mintoff; Andrew Colebatch; Lachlan McIntosh; Katrina A. Mitchell; Evangeline Shaw; Helen Rizos; Georgina V. Long; Nicholas Hayward; Grant A. McArthur; Anthony T. Papenfuss; Kieran F. Harvey; Mark Shackleton
Cancer “-omics”
Cell Fate Decisions
GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer
Samantha M. Bevill; Jose F. Olivares-Quintero; Noah Sciaky; Brian T. Golitz; Darshan Singh; Adriana S. Beltran; Naim U. Rashid; Timothy J. Stuhlmiller; Andrew Hale; Nathaniel J. Moorman; Charlene M. Santos; Steven P. Angus; Jon S. Zawistowski; Gary L. Johnson
Metabolism
Author Choice
Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism
Alessandro Valli; Matteo Morotti; Christos E. Zois; Patrick K. Albers; Tomoyoshi Soga; Katharina Feldinger; Roman Fischer; Martin Frejno; Alan McIntyre; Esther Bridges; Syed Haider; Francesca M. Buffa; Dilair Baban; Miguel Rodriguez; Oscar Yanes; Hannah J. Whittington; Hannah A. Lake; Sevasti Zervou; Craig A. Lygate; Benedikt M. Kessler; Adrian L. Harris
New Horizons in Cancer Biology
Signal Transduction and Functional Imaging
Author Choice
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Amy P. Chiu; Barbara R. Tschida; Tung-Ting Sham; Lilian H. Lo; Branden S. Moriarity; Xiao-Xiao Li; Regina C. Lo; David E. Hinton; Dewi K. Rowlands; Chi-On Chan; Daniel K.W. Mok; David A. Largaespada; Nadia Warner; Vincent W. Keng
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