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1 June 2019
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Cover Image
Cover Image
ABOUT THE COVER
Metabolic alterations underlie the acquisition of a host of protumorigenic and progression-associated phenotypes. The cover image depicts three-dimensional imaging of an irradiated MCF7 xenograft tumor in which OGA, an enzyme that catalyzes the removal of O-linked N-acetyl glucosamine, had been ablated using RNA interference (DNA damage foci, red; shRNA expression, green; vascular endothelium, cyan). Increased protein O-GlcNAcylation resulting from OGA loss was associated with faster resolution of DNA damage. Taken together, the data suggest that rewiring of the hexosamine biosynthetic pathway may drive resistance to radiotherapy. - PDF Icon PDF LinkTable of Contents
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ISSN 1541-7786
EISSN 1557-3125
Highlights
Rapid Impact
Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity
Rahul R. Aggarwal; David A. Quigley; Jiaoti Huang; Li Zhang; Tomasz M. Beer; Matthew B. Rettig; Rob E. Reiter; Martin E. Gleave; George V. Thomas; Adam Foye; Denise Playdle; Paul Lloyd; Kim N. Chi; Christopher P. Evans; Primo N. Lara; Felix Y. Feng; Joshi J. Alumkal; Eric J. Small
Cancer Genes and Networks
Author Choice
Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer
Renee E. Vickman; Jiang Yang; Nadia A. Lanman; Gregory M. Cresswell; Faye Zheng; Chi Zhang; R. W. Doerge; Scott A. Crist; Andrew D. Mesecar; Chang-Deng Hu; Timothy L. Ratliff
MCL1 and DEDD Promote Urothelial Carcinoma Progression
Andrew L. Hong; Jennifer L. Guerriero; Mihir B. Doshi; Bryan D. Kynnap; Won Jun Kim; Anna C. Schinzel; Rebecca Modiste; Amy J. Schlauch; Rosalyn M. Adam; David J. Kwiatkowski; Rameen Beroukhim; Anthony Letai; Jonathan E. Rosenberg; William C. Hahn
Potent Antineoplastic Effects of Combined PI3Kα–MNK Inhibition in Medulloblastoma
Frank Eckerdt; Jonathan B. Bell; Elspeth M. Beauchamp; Jessica Clymer; Gavin T. Blyth; Ewa M. Kosciuczuk; Quanhong Ma; David Z. Chen; Craig Horbinski; Stewart Goldman; Hidayatullah G. Munshi; Rintaro Hashizume; Leonidas C. Platanias
Cell Fate Decisions
Chromatin, Epigenetics, and RNA Regulation
Genome Maintenance
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors
Elena V. Efimova; Oliver K. Appelbe; Natalia Ricco; Steve S.-Y. Lee; Yue Liu; Donald J. Wolfgeher; Tamica N. Collins; Amy C. Flor; Aishwarya Ramamurthy; Sara Warrington; Vytautas P. Bindokas; Stephen J. Kron
Metabolism
New Horizons in Cancer Biology
Metabolic Detection of Bruton's Tyrosine Kinase Inhibition in Mantle Cell Lymphoma Cells
Seung-Cheol Lee; Alexander A. Shestov; Lili Guo; Qian Zhang; Jeffrey C. Roman; Xiaobin Liu; Hong Y. Wang; Stephen Pickup; Kavindra Nath; Pin Lu; Samuel Hofbauer; Clementina Mesaros; Y. Lynn Wang; David S. Nelson; Stephen J. Schuster; Ian A. Blair; Jerry D. Glickson; Mariusz A. Wasik
Signal Transduction and Functional Imaging
E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms
Mohit Kumar Jolly; Kathryn E. Ware; Shengnan Xu; Shivee Gilja; Samantha Shetler; Yanjun Yang; Xueyang Wang; R. Garland Austin; Daniella Runyambo; Alexander J. Hish; Suzanne Bartholf DeWitt; Jason T. George; R. Timothy Kreulen; Mary-Keara Boss; Alexander L. Lazarides; David L. Kerr; Drew G. Gerber; Dharshan Sivaraj; Andrew J. Armstrong; Mark W. Dewhirst; William C. Eward; Herbert Levine; Jason A. Somarelli
Tumor Microenvironment and Immunobiology
miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair–Deficient Colorectal Cancer by Targeting PD-L1
Mai Ashizawa; Hirokazu Okayama; Teruhide Ishigame; Aung Kyi Thar Min; Katsuharu Saito; Daisuke Ujiie; Yuko Murakami; Tomohiro Kikuchi; Yuko Nakayama; Masaru Noda; Takeshi Tada; Hisahito Endo; Shotaro Fujita; Wataru Sakamoto; Motonobu Saito; Zenichiro Saze; Tomoyuki Momma; Shinji Ohki; Kosaku Mimura; Koji Kono
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