ABOUT THE COVER
Metabolic alterations underlie major changes in tumor cell biology, including increased cell migration and metastasis. The cover image shows fluorescence microscopy of a PAI1-expressing orthotopic xenograft tumor (green) and the collagen matrix (gray) at its invasive front. PAI1 expression increased glycolysis and promoted collagen fiber alignment, both of which are associated with increased cell migration. Taken together, the data suggest that targeting cancer metabolic pathways may be an avenue to reduce metastatic spread. See the article by Humphries and colleagues (beginning on page 1142) for more information.