ABOUT THE COVER
In this issue (beginning on page 370), Mooneyham and colleagues demonstrate that UNC-45A is a novel microtubule-associated protein that antagonizes the effect of paclitaxel in ovarian cancer cells, leading to chemoresistance. The immunofluorescent cover image shows strong co-localization between UNC-45A (red) and alpha tubulin (green) in synchronized metaphase HeLa cells. This finding was key in the later identification of UNC-45A as a novel microtubule-associated protein that functions to destabilize microtubules and confer paclitaxel resistance. Together, this study reveals UNC-45A as a promising biomarker and molecular target for paclitaxel-resistant human cancers.
Cover image by Mooneyham not featured in article.