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ABOUT THE COVER
IDH1 hotspot mutations are likely early events in gliomagenesis; however, they can be lost in treated secondary glioblastomas. The cover depicts the DNA helix containing CpG island methylation as bright white foci. Though IDH1 mutations are thought to drive a CpG methylation-high phenotype in glioma, Moure and colleagues found that many methylated foci throughout the genome were retained even after CRISPR/Cas9-mediated knockout of the IDH1 mutant allele. See the Highlight on page 1959 and the article on page 2042 for more information. Artist credit: Samantha Moure.